Multifocal motor neuropathy with conduction block associated with metastatic lymphoma of the nervous system.

abstract：:Magnetic resonance imaging (MRI) or computerized tomography (CT) is routinely performed after resection of brain metastases (BrM), regardless of whether there are specific clinical concerns about residual tumor or potential complications. Routine imaging studies contribute a significant amount to the cost of medical c...

journal_title：Journal of neuro-oncology

authors： Benveniste RJ,Ferraro N,Tsimpas A

更新日期：2014-06-01 00:00:00

abstract：:Treatment options and prognosis remains poor for patients with recurrent glioblastoma multiforme. These tumors are highly vascularised and over express angiogenic factors such as vascular endothelial growth factor and may potentially be responsive to antiangiogenic therapies. We present the results of a phase II trial...

journal_title：Journal of neuro-oncology

authors： Marx GM,Pavlakis N,McCowatt S,Boyle FM,Levi JA,Bell DR,Cook R,Biggs M,Little N,Wheeler HR

更新日期：2001-08-01 00:00:00

abstract：:When surgery and radiation are no longer treatment options, salvage systemic therapy has been used for recurrent meningiomas with little compelling evidence to suggest effectiveness. Patients with surgery and radiation refractory recurrent meningiomas were treated with the oral multifunctional tyrosine kinase inhibito...

journal_title：Journal of neuro-oncology

authors： Raizer JJ,Grimm SA,Rademaker A,Chandler JP,Muro K,Helenowski I,Rice L,McCarthy K,Johnston SK,Mrugala MM,Chamberlain M

更新日期：2014-03-01 00:00:00

abstract：:Membrane-type MMPs (MT-MMPs) constitute a growing subclass of recently identified matrix metalloproteinases (MMPs). In addition to the highly conserved MMP functional domains, the MT-MMPs have additional insertion sequences (IS) that confer unique functional roles. While most of the MMPs are secreted, the MT-MMPs are ...

journal_title：Journal of neuro-oncology

authors： Fillmore HL,VanMeter TE,Broaddus WC

更新日期：2001-06-01 00:00:00

abstract：PURPOSE:A major challenge to developing new therapies for patients with malignant brain tumors is that relatively few small molecule anticancer drugs penetrate the blood-brain barrier (BBB) well enough to provide therapeutically effective concentrations in brain tissue before drug exposure in non-CNS tissues results in...

journal_title：Journal of neuro-oncology

authors： Ciesielski MJ,Bu Y,Munich SA,Teegarden P,Smolinski MP,Clements JL,Lau JYN,Hangauer DG,Fenstermaker RA

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:Ferumoxtran-10 belongs to the Ultra Small Particles of Iron Oxide (USPIO) class of contrast agents and induces delayed tumor enhancement in brain tumors, reflecting the trapping of iron oxide particles by the macrophages and activated microglia. The aim of the study was to compare Ferumoxtran-10 contrast enhanc...

journal_title：Journal of neuro-oncology

authors： Kremer S,Pinel S,Védrine PO,Bressenot A,Robert P,Bracard S,Plénat F

更新日期：2007-06-01 00:00:00

abstract：:Fibroblast growth factor-2 (FGF-2) is involved as an autocrine growth factor in the autonomous proliferation of glioma cells. To develop a new strategy for treating patients with glioma, we studied the effect on human glioma cells of a 16-mer oligopeptide with conformational similarity to the putative receptor-binding...

journal_title：Journal of neuro-oncology

authors： Kono K,Ueba T,Takahashi JA,Murai N,Hashimoto N,Myoumoto A,Itoh N,Fukumoto M

更新日期：2003-06-01 00:00:00

abstract：:The anti-Hu syndrome is the most common paraneoplastic neurologic syndrome but the exact mechanism of immune mediated neuronal injury remains unknown. Anti-Hu antibodies do not appear to play a pivotal role in the pathogenesis of the disease. To assess cell-mediated immunity, we selected 51 peptides from the Hu-D sequ...

journal_title：Journal of neuro-oncology

authors： Rousseau A,Benyahia B,Dalmau J,Connan F,Guillet JG,Delattre JY,Choppin J

更新日期：2005-02-01 00:00:00

abstract：:Six children (ages 2 to 14 years) with recurrent or poor risk primary brain tumors were treated with the '8 drugs in 1 day' chemotherapy regimen. As renal function deteriorated (median after five cycles), carboplatin was substituted in place of cisplatin at a median dose of 300 mg/m2 as a one hour infusion at hour thr...

journal_title：Journal of neuro-oncology

authors： Chan KW,Fryer CJ,Steinbok P

更新日期：1990-10-01 00:00:00

abstract：PURPOSE:The poor results from treatment of high grade glioma prompted us to explore new protocols involving concurrent radio-chemotherapy. Our primary objective was to evaluate the feasibility of very early postoperative chemotherapy with BCNU, concurrent radio-chemotherapy with carboplatin and teniposide, and post-rad...

journal_title：Journal of neuro-oncology

authors： Brandes AA,Rigon A,Zampieri P,Scelzi E,Amistà P,Berti F,Rotilio A,Gardiman M,Fiorentino MV

更新日期：1996-12-01 00:00:00

abstract：:This paper reviews the development of low-energy light ion accelerator-based neutron sources (ABNSs) for the treatment of brain tumors through an intact scalp and skull using boron neutron capture therapy (BNCT). A major advantage of an ABNS for BNCT over reactor-based neutron sources is the potential for siting withi...

journal_title：Journal of neuro-oncology

authors： Blue TE,Yanch JC

更新日期：2003-03-01 00:00:00

abstract：:Cyclin-dependent kinase 4 inhibitor (CDKN2/p16) is a cell cycle regulatory protein that has been demonstrated to be inactivated by mutations, deletions or transcriptional silencing during pathogenesis of a variety of human malignancies. We studied the correlation of CDKN2/p16 expression with cell proliferation activit...

journal_title：Journal of neuro-oncology

authors： Miettinen H,Kononen J,Sallinen P,Alho H,Helen P,Helin H,Kalimo H,Paljärvi L,Isola J,Haapasalo H

更新日期：1999-02-01 00:00:00

abstract：:Retaspimycin hydrochloride (IPI-504), an Hsp90 (heat shock protein 90) inhibitor, has shown activity in multiple preclinical cancer models, such as lung, breast and ovarian cancers. However, its biological effects in gliomas and normal brain derived cellular populations remain unknown. In this study, we profiled the e...

journal_title：Journal of neuro-oncology

authors： Di K,Keir ST,Alexandru-Abrams D,Gong X,Nguyen H,Friedman HS,Bota DA

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The postoperative cerebellar mutism syndrome (CMS) is an unique acute postoperative complication characterized by transient decrease in speech output (often mutism), apathy, irritability as well as global cerebellar dysfunction. As much as 25% of patients undergoing a resection of a cerebellar...

journal_title：Journal of neuro-oncology

authors： Siffert J,Poussaint TY,Goumnerova LC,Scott RM,LaValley B,Tarbell NJ,Pomeroy SL

更新日期：2000-05-01 00:00:00

abstract：:Gender-specific incidence patterns and the presence of hormonal receptors on tumor cells suggest that sex hormones may play a role in the onset of primary brain tumors. However, epidemiological studies on the relation of hormonal risk factors to the risk of brain tumors have been inconsistent. We examined the role of ...

journal_title：Journal of neuro-oncology

authors： Anic GM,Madden MH,Nabors LB,Olson JJ,LaRocca RV,Thompson ZJ,Pamnani SJ,Forsyth PA,Thompson RC,Egan KM

更新日期：2014-06-01 00:00:00

abstract：:Recurrent pediatric high-grade glioma is a leading cause of cancer-related death in children. We report results of a systematic review and meta-analysis investigating survival outcome in pediatric patients with recurrent high-grade glioma over the last 20 years. MEDLINE/PubMed, EMBASE, Web of Science and Cochrane Revi...

journal_title：Journal of neuro-oncology

authors： Kline C,Felton E,Allen IE,Tahir P,Mueller S

更新日期：2018-03-01 00:00:00

abstract：:Mucus-secreting adenomas or acinar adenoma of the choroid plexus are very rare. We report the case of a 79-year-old male with a 3-year history of occipital headaches with vomiting, ataxia and cerebellar signs. He was first seen due to difficulty while walking. He was admitted to the hospital with significant tumor exp...

journal_title：Journal of neuro-oncology

authors： Rembao-Bojórquez D,Vega R,Bermúdez-Maldonado L,Gutiérrez R,Salinas C,Tena-Suck M

更新日期：2007-06-01 00:00:00

abstract：:Death ligand-mediated apoptosis is a promising strategy of gene therapy for human malignant glioma. We here report that the infection of human malignant glioma cell lines with an adenoviral vector encoding full length human Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand (Ad-Apo2L/TRAIL) results in...

journal_title：Journal of neuro-oncology

authors： Naumann U,Waltereit R,Schulz JB,Weller M

更新日期：2003-01-01 00:00:00

abstract：:Central nervous system atypical teratoid/rhabdoid tumor (ATT/RT) of infancy and childhood is a unique histologic entity with an extremely aggressive natural history. Standard therapy for infant and childhood medulloblastoma, for which this entity is often mistaken, has been ineffective; most children survive less than...

journal_title：Journal of neuro-oncology

authors： Hilden JM,Watterson J,Longee DC,Moertel CL,Dunn ME,Kurtzberg J,Scheithauer BW

更新日期：1998-12-01 00:00:00

abstract：:We report one year follow up of a case of extramedullary hematopoiesis within the clivus. The imaging findings, brief clinical course, and endoscopic transphenoidal approach are described. A 29-year-old female with thalassemia developed worsening cranial nerve signs. After imaging studies discovered a large clival mas...

journal_title：Journal of neuro-oncology

authors： Reames DL,Lindstrom K,Raghavan P,Jane J Jr

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:Atypical and malignant meningiomas are at high risk for local failure. The role of radiation therapy (RT) and dose levels required to improve tumor control are poorly defined. This study reviews our experience with RT. MATERIAL AND METHODS:Thirty-one patients underwent fractionated RT for atypical (AM, 15 pa...

journal_title：Journal of neuro-oncology

authors： Hug EB,Devries A,Thornton AF,Munzenride JE,Pardo FS,Hedley-Whyte ET,Bussiere MR,Ojemann R

更新日期：2000-06-01 00:00:00

abstract：:Some unresectable and symptomatic meningiomas recur after conventional radiation therapy or stereotactic radiosurgery and are a therapeutic challenge. Evidence-based data from medical therapy for patients with recurrent meningioma can be deemed insufficient. Because of the prevalent expression of PDGF receptors in men...

journal_title：Journal of neuro-oncology

authors： Horak P,Wöhrer A,Hassler M,Hainfellner J,Preusser M,Marosi C

更新日期：2012-09-01 00:00:00

abstract：PURPOSE:Glioblastoma multiforme (GBM) is a common and aggressive malignancy associated with poor prognosis. Characteristics and treatment of long-term survivors are of particular interest in efforts to improve outcomes. Therefore, the objective of this study was to examine trends and prognostic factors for 3-year survi...

journal_title：Journal of neuro-oncology

authors： Zreik J,Moinuddin FM,Yolcu YU,Alvi MA,Chaichana KL,Quinones-Hinojosa A,Bydon M

更新日期：2020-05-01 00:00:00

abstract：:Human recombinant tumor necrosis factor-alpha (rTNF-alpha) was administered to normal Fischer 344 rats by stereotaxic intracerebral (IC) injection. Animals receiving a single injection of either 6 x 10(4) U rTNF-alpha or an equivalent volume of excipient (vehicle) in their right parietal lobe. In order to demonstrate ...

journal_title：Journal of neuro-oncology

authors： Wright JL,Merchant RE

更新日期：1994-01-01 00:00:00

abstract：:Various histological types of tumors arise in the pineal region. The most common tumors are pineal parenchymal tumors and germ cell tumors. Pineal parenchymal tumors are divided into pineocytoma, pineal parenchymal tumor with intermediate differentiation and pineoblastoma. Pineocytomas are well-differentiated tumors a...

journal_title：Journal of neuro-oncology

authors： Hirato J,Nakazato Y

更新日期：2001-09-01 00:00:00

abstract：:Glioblastomas (GBM) may originate de novo (primary), or following transformation from a lower grade glioma (secondary), and it has been postulated that these tumors may have different biological behaviors. We performed a correlative analysis involving 204 patients with glioma treated prospectively on NCCTG clinical tr...

journal_title：Journal of neuro-oncology

authors： Jaeckle KA,Decker PA,Ballman KV,Flynn PJ,Giannini C,Scheithauer BW,Jenkins RB,Buckner JC

更新日期：2011-08-01 00:00:00

abstract：:Paraneoplastic cerebellar degeneration is a rare neurological disorder that frequently precedes the detection of malignancy. Here, we report the case of a 60 year-old woman with locally advanced squamous cell carcinoma of the tongue who developed a subacute cerebellar syndrome associated with the presence of anti-CV2/...

journal_title：Journal of neuro-oncology

authors： Saloustros E,Zaganas I,Mavridis M,Vamvakas L,Plaitakis A,Georgoulias V,Mavroudis D

更新日期：2010-04-01 00:00:00

abstract：:Recurrent and progressive non-GBM gliomas are a diverse group of brain tumors that often respond poorly to adjuvant chemotherapy treatment. Regional intra-arterial (IA) administration of chemotherapy may result in increased tumor uptake of drug, with improvement in response rates and time to progression (TTP). Twenty-...

journal_title：Journal of neuro-oncology

authors： Newton HB,Slivka MA,Stevens CL,Bourekas EC,Christoforidis GA,Baujan MA,Chakeres DW

更新日期：2002-01-01 00:00:00

abstract：:In the treatment of malignant glioma, chemotherapy plays a critical role as do surgical resection and irradiation. Cepharanthine (CEP), a biscoclaurine-derived alkaloid, reportedly potentiates the effects of antitumor agents and induces apoptosis in some cancer cells. Here, we examined the effects of CEP, alone and in...

journal_title：Journal of neuro-oncology

authors： Kono K,Takahashi JA,Ueba T,Mori H,Hashimoto N,Fukumoto M

更新日期：2002-01-01 00:00:00

abstract：:A 44 year-old man with subcutaneous meningioma and rare combination of spinal lesions, consisting of dermal sinus and lipoma of the filum terminale. The literature concerning the subcutaneous meningioma is reviewed and the embryogenesis of these lesions is discussed. ...

journal_title：Journal of neuro-oncology

authors： Qasho R,Lunardi P,Lo Bianco FM,di Stefano M

更新日期：1998-05-01 00:00:00