Association between hospital volume and receipt of treatment and survival in patients with glioblastoma.

abstract：:Pituitary tumors were experimentally induced in female Wistar rats by repeated injections of estradiol dipropionate. The hypothalamus and pituitary tumors were studied simultaneously by fluorescence histochemistry and immunohistochemistry. The pituitary gland became larger with a concomitant increase of serum prolacti...

journal_title：Journal of neuro-oncology

authors： Fujimoto M,Yoshino E,Hirakawa K,Chihara K,Ibata Y

更新日期：1987-01-01 00:00:00

abstract：:We used double-label quantitative autoradiography to measure blood flow (with 131I-iodoantipyrine) and blood-to-tissue transport of 14C-alpha aminoisobutyric acid, AIB) in thirteen 9L gliosarcomas transplanted intracerebrally into Fischer-344 rats. Microscopically, the typical pattern of 9L tumor growth was observed: ...

journal_title：Journal of neuro-oncology

authors： Fross RD,Warnke PC,Groothuis DR

更新日期：1991-12-01 00:00:00

abstract：:Children with a brain tumor (BT) are at risk for a number of physical and cognitive problems that may lower their health-related quality of life (HRQoL). Executive functioning (EF) and intellectual ability are hypothesized to associate with HRQoL and deficits in these areas may be amenable to interventions. This study...

journal_title：Journal of neuro-oncology

authors： Netson KL,Ashford JM,Skinner T,Carty L,Wu S,Merchant TE,Conklin HM

更新日期：2016-06-01 00:00:00

abstract：:We evaluated the results of stereotactic radiosurgery (SRS) alone using gamma knife (GK) for selected patients with 1-10 brain metastases without prophylactic whole-brain radiation therapy (WBRT) among JLGK0901-eligible cases. Seven hundred seventy-eight consecutive cases meeting the following JLGK0901 study inclusion...

journal_title：Journal of neuro-oncology

authors： Serizawa T,Hirai T,Nagano O,Higuchi Y,Matsuda S,Ono J,Saeki N

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:Comparison of the influence of two different brain tumors (C6 and CNS1 glioma) on methotrexate (MTX) disposition in plasma, brain, and tumor tissue extracellular fluid (ECF). METHODS:Serial collection of plasma samples and brain ECF dialysates after i.v. bolus administration of MTX (50 mg kg(-1)) for 4 h. Quan...

journal_title：Journal of neuro-oncology

authors： Dukic SF,Kaltenbach ML,Heurtaux T,Hoizey G,Lallemand A,Vistelle R

更新日期：2004-03-01 00:00:00

abstract：:Anti-VEGF therapy with Bevacizumab (BEV) is widely used in cases of relapsed high-grade glioma (HGG). Arterial hypertension is a known side effect of anti-VEGF therapy. 42 Patients with relapsed HGG were treated with BEV 10 mg/kg on days 1 and 15 of 28-day cycles in addition to treatment with 40 mg TMZ daily until dis...

journal_title：Journal of neuro-oncology

authors： Bumes E,Rzonsa S,Hutterer M,Proescholdt M,Bogdahn U,Riemenschneider MJ,Uhl M,Wendl C,Hau P

更新日期：2016-03-01 00:00:00

abstract：:The value of perfusion and diffusion-weighted MRI in differentiating histological subtypes according to the 2007 WHO glioma classification scheme (i.e. astrocytoma vs. oligodendroglioma) and genetic subtypes according to the 2016 WHO reclassification (e.g. 1p/19q co-deletion and IDH1 mutation status) in WHO grade II a...

journal_title：Journal of neuro-oncology

authors： Leu K,Ott GA,Lai A,Nghiemphu PL,Pope WB,Yong WH,Liau LM,Cloughesy TF,Ellingson BM

更新日期：2017-08-01 00:00:00

abstract：:Resveratrol (Res) has been reported to inhibit tumor initiation, promotion, and progression in a variety of cell culture systems depending on the specific cell type and cellular environment. In the present study, we determined the effect of Res on the cell growth and apoptosis of rat glioma C6 cell line as well as mou...

journal_title：Journal of neuro-oncology

authors： Zhang W,Fei Z,Zhen HN,Zhang JN,Zhang X

更新日期：2007-02-01 00:00:00

abstract：:High expression of ERBB2 has been reported in medulloblastoma and ependymoma; EGFR is amplified and over-expressed in brainstem glioma suggesting these proteins as potential therapeutic targets. We conducted a molecular biology (MB) and phase II study to estimate inhibition of tumor ERBB signaling and sustained respon...

journal_title：Journal of neuro-oncology

authors： Fouladi M,Stewart CF,Blaney SM,Onar-Thomas A,Schaiquevich P,Packer RJ,Goldman S,Geyer JR,Gajjar A,Kun LE,Boyett JM,Gilbertson RJ

更新日期：2013-09-01 00:00:00

abstract：:The Coronavirus pandemic has created unprecedented strain on medical resources at health care institutions around the world. At many institutions, this has resulted in efforts to prioritize cases with an attempt to balance the acuity of medical needs with available resources. Here, we provide a framework for instituti...

journal_title：Journal of neuro-oncology

authors： Ramakrishna R,Zadeh G,Sheehan JP,Aghi MK

更新日期：2020-05-01 00:00:00

abstract：:Intracranial Hodgkin's lymphoma (ICHL) in the HIV positive population is a rarely reported event with only three prior cases reported in the literature. In these prior reports, the outcome of the patients was uncertain or very poor. We report here the case of an HIV seropositive patient with an isolated intracranial r...

journal_title：Journal of neuro-oncology

authors： Ramchandar K,Verhey LH,Jha NK,Murty NK,McMillan W

更新日期：2008-08-01 00:00:00

abstract：:Patients with unresectable glioblastoma or anaplastic astrocytoma have a dismal prognosis. The role of neoadjuvant chemotherapy prior to irradiation in these patients has been studied primarily in non-randomized studies. We have compared the effect of neoadjuvant chemotherapy plus radiotherapy versus concomitant radio...

journal_title：Journal of neuro-oncology

authors： Capdevila L,Cros S,Ramirez JL,Sanz C,Carrato C,Romeo M,Etxaniz O,Hostalot C,Massuet A,Cuadra JL,Villà S,Balañà C

更新日期：2014-03-01 00:00:00

abstract：:Pediatric brain gliomas are not always amenable for complete surgical excision, therefore adjuvant treatment for a large tumor mass is often required. As tumor volume shrinkage may not be a reliable method for assessing response to treatment, information about the tumor growth potential is desirable for an adequate fo...

journal_title：Journal of neuro-oncology

authors： Lazareff JA,Gupta RK,Alger J

更新日期：1999-02-01 00:00:00

abstract：:High-dose (1-3.5 g/m2) methotrexate (MTX) followed by whole-brain radiation therapy (WBRT) has consistently improved length of survival in primary central nervous system lymphoma (PCNSL), but the prognosis remains dismal. To optimize and enhance the dose intensity of MTX, we applied MTX at 8 g/m2 to 20 patients with P...

journal_title：Journal of neuro-oncology

authors： Watanabe T,Katayama Y,Yoshino A,Komine C,Yokoyama T,Fukushima T

更新日期：2003-05-01 00:00:00

abstract：:Direct involvement of the brain by chronic lymphocytic leukemia (CLL) is extremely rare. This is the second documented case. A 63 year-old-man presented with motor deficits. Conventional radiographic imaging showed no abnormalities but an MRI scan of the head showed a high signal intensity lesion in the left cerebellu...

journal_title：Journal of neuro-oncology

authors： Pohar S,deMetz C,Poppema S,Hugh J

更新日期：1993-04-01 00:00:00

abstract：:Identification of cytotoxic T lymphocyte (CTL) epitopes from additional tumor antigens is essential for the development of specific immunotherapy of malignant tumors. Neuritin, a recently discovered antigen overexpressed in astrocytoma, is considered to be a promising target for biological therapy. In the present stud...

journal_title：Journal of neuro-oncology

authors： Yang Z,Zhao T,Liu Y,Gong Z,Cheng S,Yang Q

更新日期：2013-08-01 00:00:00

abstract：:Although their neurocognitive performance is one of the major concerns of patients with high-grade gliomas (HGG) and although neurocognitive deficits have been described to be associated with negative outcome, neurocognitive rehabilitation is usually not integrated into the routine care of patients with malignant glio...

journal_title：Journal of neuro-oncology

authors： Hassler MR,Elandt K,Preusser M,Lehrner J,Binder P,Dieckmann K,Rottenfusser A,Marosi C

更新日期：2010-03-01 00:00:00

abstract：:NeuroCogFX is a short yet comprehensive computer-based neuropsychological battery of tests developed to investigate neurological patients for cognitive dysfunction after potentially neurotoxic therapy. NeuroCogFX had been standardized in a group of 242 healthy controls (Fliessbach et al., Fortschr Neurol Psychiatr 74:...

journal_title：Journal of neuro-oncology

authors： Fliessbach K,Rogowski S,Hoppe C,Sabel M,Goeppert M,Helmstaedter C,Calabrese P,Schackert G,Tonn JC,Simon M,Schlegel U

更新日期：2010-12-01 00:00:00

abstract：:Topotecan was studied as a 72 h infusion given every 3 weeks. Treatment began at a dose of 1.0 mg/m2/day and was increased to 1.25 mg/m2/day after the first 6 patients tolerated this higher dose without excessive toxicities. Eighty-eight evaluable children were accrued in 6 strata. There were no complete nor partial r...

journal_title：Journal of neuro-oncology

authors： Kadota RP,Stewart CF,Horn M,Kuttesch JF Jr,Burger PC,Kepner JL,Kun LE,Friedman HS,Heideman RL

更新日期：1999-05-01 00:00:00

abstract：:Cavernous sinus is an uncommon site of metastasis for the head and neck tumors, and especially for the tumors of parotid gland. The case reported here is the second reported case of parotid carcinoma metastatic to the cavernous sinus, proven by histopathology. Also it is the first reported parotid gland acinic cell ca...

journal_title：Journal of neuro-oncology

authors： Yildirim N,Oksüzoğlu B,Vural M,Han O,Zengin N

更新日期：2005-06-01 00:00:00

abstract：:Thirty-six infants and children with brain stem glioma diagnosed between 1967 and 1980 were reviewed. Posterior fossa craniotomy was performed in 25, with biopsy or partial resection in 18, cyst aspiration in 2, and exploration alone in 5. The 19 surgical specimens obtained revealed neoplastic cells in 15 but only gli...

journal_title：Journal of neuro-oncology

authors： Tomita T,McLone DG,Naidich TP

更新日期：1984-01-01 00:00:00

abstract：:Patients with metastatic disease are living longer and may be confronted with locally or regionally recurrent brain metastases (BM) after prior stereotactic radiosurgery (SRS) or fractionated stereotactic radiotherapy (FSRT). This study analyzes outcomes in patients without prior whole brain radiotherapy (WBRT) who we...

journal_title：Journal of neuro-oncology

authors： Kim DH,Schultheiss TE,Radany EH,Badie B,Pezner RD

更新日期：2013-10-01 00:00:00

abstract：:Treatment options and prognosis remains poor for patients with recurrent glioblastoma multiforme. These tumors are highly vascularised and over express angiogenic factors such as vascular endothelial growth factor and may potentially be responsive to antiangiogenic therapies. We present the results of a phase II trial...

journal_title：Journal of neuro-oncology

authors： Marx GM,Pavlakis N,McCowatt S,Boyle FM,Levi JA,Bell DR,Cook R,Biggs M,Little N,Wheeler HR

更新日期：2001-08-01 00:00:00

abstract：PURPOSE:To evaluate the effectiveness of complete resection and postoperative radiotherapy in spinal cord ependymomas. METHODS AND MATERIALS:We conducted a retrospective study over 20 patients (13 males and 7 females) with histologically confirmed spinal cord ependymomas between July 1985 and April 2001. Among them, 1...

journal_title：Journal of neuro-oncology

authors： Lin YH,Huang CI,Wong TT,Chen MH,Shiau CY,Wang LW,Ming-Tak Ho D,Yen SH

更新日期：2005-01-01 00:00:00

abstract：:To evaluate the safety and efficacy of hypofractionated radiotherapy (RT) with a standard temozolomide (TMZ) regimen for adults with newly diagnosed glioblastoma multiforme (GBM), twenty-six consecutive adults (range 39-79 years) who met our enrollment criteria received short courses of hypofractionated RT (45 Gy in 1...

journal_title：Journal of neuro-oncology

authors： Terasaki M,Eto T,Nakashima S,Okada Y,Ogo E,Sugita Y,Tokutomi T,Shigemori M

更新日期：2011-04-01 00:00:00

abstract：:In the present study we investigated the feasibility and effectiveness of a new biweekly schedule of fotemustine (FTM) in patients with recurrent glioblastoma, after at least one previous treatment. The primary endpoint was progression-free survival at 6 months; secondary objectives were clinical response, overall sur...

journal_title：Journal of neuro-oncology

authors： Addeo R,Caraglia M,De Santi MS,Montella L,Abbruzzese A,Parlato C,Vincenzi B,Carraturo M,Faiola V,Genovese M,Cennamo G,Del Prete S

更新日期：2011-05-01 00:00:00

abstract：:BCNU is increasingly used in low ethanol (ETOH) concentrations, 5% dextrose-water (D5W), or normal saline (NS) solutions, especially for intra-arterial and prolonged (e.g., 3 day) intravenous (IV) infusions. Little work, however, has been done to evaluate BCNU decomposition rates in concentrations, diluents, and tempe...

journal_title：Journal of neuro-oncology

authors： Tepe P,Hassenbusch SJ,Benoit R,Anderson JH

更新日期：1991-04-01 00:00:00

abstract：:Two distinct mechanisms, vasculogenesis and angiogenesis implement the formation of the vascular network in the embryo. Vasculogenesis gives rise to the heart and the first primitive vascular plexus inside the embryo and in its surrounding membranes, as the yolk sac circulation. Angiogenesis is responsible for the rem...

journal_title：Journal of neuro-oncology

authors： Patan S

更新日期：2000-10-01 00:00:00

abstract：INTRODUCTION:Malignant gliomas have a dismal prognosis and significant efforts are being made to develop more effective treatments. Sonodynamic therapy (SDT) is an emerging modality for cancer treatment which combines ultrasound with sonosensitizers to produce a localized cytotoxic effect. The aim of this study is to d...

journal_title：Journal of neuro-oncology

authors： Prada F,Sheybani N,Franzini A,Moore D,Cordeiro D,Sheehan J,Timbie K,Xu Z

更新日期：2020-07-01 00:00:00

abstract：:Assessing central nervous system (CNS) involvement in patients with lymphoma or carcinoma is important in determining therapy and prognosis. Progranulin (PGRN) is a secreted glycosylated protein with roles in cancer growth and survival; it is highly expressed in aggressive cancer cell lines and specimens from many can...

journal_title：Journal of neuro-oncology

authors： Kimura A,Takemura M,Serrero G,Yoshikura N,Hayashi Y,Saito K,Inuzuka T

更新日期：2018-05-01 00:00:00