Executive dysfunction is associated with poorer health-related quality of life in pediatric brain tumor survivors.

abstract：:A prospective pilot study was performed in order to assess the safety of treating recurrent malignant gliomas (MGs) with locally infused autologous tumor infiltrating lymphocytes (TILs) and recombinant interleukin-2 (rIL-2). Six patients were entered between June 27, 1994 and June 2, 1995 and followed until July 1, 19...

journal_title：Journal of neuro-oncology

authors： Quattrocchi KB,Miller CH,Cush S,Bernard SA,Dull ST,Smith M,Gudeman S,Varia MA

更新日期：1999-01-01 00:00:00

abstract：:The Hedgehog (Hh) signaling pathway has been implicated in the most common childhood brain tumor, medulloblastoma (MB). Given the toxicity of post-surgical treatments for MB, continued need exists for new, targeted therapies. Based upon our finding that Neuropilin (Nrp) transmembrane proteins are required for Hh signa...

journal_title：Journal of neuro-oncology

authors： Hayden Gephart MG,Su YS,Bandara S,Tsai FC,Hong J,Conley N,Rayburn H,Milenkovic L,Meyer T,Scott MP

更新日期：2013-11-01 00:00:00

abstract：:Twenty-eight patients with malignant brain tumors (16 with primary brain tumors and 12 with brain metastases) progressing after cranial irradiation with or without chemotherapy received varying doses of intracarotid VP-16. Courses of therapy were repeated every 4 weeks along with computerized axial tomography scan and...

journal_title：Journal of neuro-oncology

authors： Feun LG,Lee YY,Yung WK,Savaraj N,Wallace S

更新日期：1987-01-01 00:00:00

abstract：:Advancements in immunotherapeutics promise new possibilities for the creation of glioblastoma (GBM) treatment options. Ongoing work in cancer stem cell biology has progressively elucidated the role of this tumor sub-population in oncogenesis and has distinguished them as prime therapeutic targets. Current clinical tri...

journal_title：Journal of neuro-oncology

authors： Esparza R,Azad TD,Feroze AH,Mitra SS,Cheshier SH

更新日期：2015-07-01 00:00:00

abstract：:The type III mutant epidermal growth factor receptor (EGFR) is expressed on the cell surface of a subset of glioma, but not of normal tissues. In this study, we investigated the in vivo kinetics of 3C10 mouse monoclonal antibody (mAb), specifically recognizing the type III mutant EGFR (EGFRvIII), using athymic nude mi...

journal_title：Journal of neuro-oncology

authors： Takasu S,Takahashi T,Okamoto S,Oriuchi N,Nakayashiki N,Okamoto K,Muramatsu H,Hayashi T,Nakahara N,Mizuno M,Wakabayashi T,Higuchi T,Endo K,Kozaki K,Miyaishi O,Saga S,Ueda R,Yoshida J,Yoshikawa K

更新日期：2003-07-01 00:00:00

abstract：:This adjunct to a prospective phase II blinded study of 48 patients with recurrent malignant glioma evaluated the predictive reliability of an extreme drug resistance (EDR) to identify clinical resistance to irinotecan (CPT-11), using fresh tumor biopsies obtained from recurrent patients immediately prior to their fir...

journal_title：Journal of neuro-oncology

authors： Parker RJ,Fruehauf JP,Mehta R,Filka E,Cloughesy T

更新日期：2004-02-01 00:00:00

abstract：:Six children (ages 2 to 14 years) with recurrent or poor risk primary brain tumors were treated with the '8 drugs in 1 day' chemotherapy regimen. As renal function deteriorated (median after five cycles), carboplatin was substituted in place of cisplatin at a median dose of 300 mg/m2 as a one hour infusion at hour thr...

journal_title：Journal of neuro-oncology

authors： Chan KW,Fryer CJ,Steinbok P

更新日期：1990-10-01 00:00:00

abstract：:The effectiveness of radiotherapy and chemotherapy in high grade gliomas (HGG) depends on tumor micro-environment. We summarize our experience of the influence of spinal cord stimulation (SCS) on this micro-environment. Patients with HGG (n = 26) were assessed pre- and post-SCS, using: (1) Doppler in middle cerebral a...

journal_title：Journal of neuro-oncology

authors： Clavo B,Robaina F,Valcarcel B,Catala L,Perez JL,Cabezon A,Jorge IJ,Fiuza D,Hernandez MA,Jover R,Carreras JL

更新日期：2012-01-01 00:00:00

abstract：:Measurement of oxygen pressure (pO2) in tumor tissue is important, because pO2 is a major factor for radiosensitivity in malignant glioma treatment. We attempted to elucidate the changes in pO2 level in glioblastoma tissue of patients under various conditions. Eighteen patients with newly diagnosed glioblastoma were r...

journal_title：Journal of neuro-oncology

authors： Beppu T,Kamada K,Yoshida Y,Arai H,Ogasawara K,Ogawa A

更新日期：2002-05-01 00:00:00

abstract：:Glioma is the most common primary brain tumor in adults. Six3 is a human homologue of the highly conserved sine oculis gene family and essential transcription regulatory factor in process of eye and fetal forebrain development. However, little is known about the role of Six3 in human tumorigenesis. The aim of this stu...

journal_title：Journal of neuro-oncology

authors： Zhang B,Shen C,Ge F,Ma T,Zhang Z

更新日期：2017-07-01 00:00:00

abstract：:A 9-day-old female presented with a large infra- and supratentorial medulloblastoma was treated by surgery, irradiation and chemotherapy. The infant suffered from vomit a few days after birth. She was hospitalized shortly thereafter, when head enlargement was noted. A CT scan taken on admission disclosed a large mass ...

journal_title：Journal of neuro-oncology

authors： Kayama T,Yoshimoto T,Shimizu H,Sakurai Y

更新日期：1993-02-01 00:00:00

abstract：:Choroid plexus papillomas (CPPs) are generally regarded as benign tumours, with a favourable long-term prognosis. Complete resection should result in cure. We present a case of diffuse craniospinal seeding from an apparently completely resected fourth ventricular primary tumour. A 51-year-old male is discussed, who pr...

journal_title：Journal of neuro-oncology

authors： McEvoy AW,Galloway M,Revesz T,Kitchen ND

更新日期：2002-02-01 00:00:00

abstract：:Fibroblast growth factor-2 (FGF-2) is involved as an autocrine growth factor in the autonomous proliferation of glioma cells. To develop a new strategy for treating patients with glioma, we studied the effect on human glioma cells of a 16-mer oligopeptide with conformational similarity to the putative receptor-binding...

journal_title：Journal of neuro-oncology

authors： Kono K,Ueba T,Takahashi JA,Murai N,Hashimoto N,Myoumoto A,Itoh N,Fukumoto M

更新日期：2003-06-01 00:00:00

abstract：:Degradation and remodelling of the extracellular matrix has been investigated, with the main focus on the balance between matrix metalloproteinases (MMP) and tissue inhibitor of metalloproteinases (TIMP). Recent reports disclose the presence of a novel MMP-inhibiting cell membrane-anchored glycoprotein designated 'rev...

journal_title：Journal of neuro-oncology

authors： Yoshida D,Nomura R,Teramoto A

更新日期：2008-09-01 00:00:00

abstract：:Four cases of intracranial osteosarcoma are reported. In three cases the tumors were primary neoplasms arising from the sellar region, base of the occiput and the parieto-occipital area. One case represented osteosarcoma metastatic to the cerebellum, a site not previously described, from a primary tumor at the femur. ...

journal_title：Journal of neuro-oncology

authors： Ashkan K,Pollock J,D'Arrigo C,Kitchen ND

更新日期：1998-10-01 00:00:00

abstract：:The outcome of children less than 3 years of age with medulloblastoma has been poor in comparison to older children. The cure rates were below 30%, and the quality of life for cured children was frequently reduced by a complex syndrome of long-term sequelae including intellectual retardation and growth hormone deficie...

journal_title：Journal of neuro-oncology

authors： Schmandt S,Kühl J

更新日期：1998-06-01 00:00:00

abstract：:The p21WAF1/Cip1 (p21) protein, a negative regulator of G1 checkpoint control, was overexpressed in the majority of human gliomas. To investigate whether p21 expression in brain metastases from various systemic origins is similar to that in gliomas and whether p21 expression is regulated differently in brain metastase...

journal_title：Journal of neuro-oncology

authors： Ruan S,Fuller G,Levin V,Bruner JM,Zhang W

更新日期：1998-05-01 00:00:00

abstract：:Several molecular markers have been proposed as predictors of outcome in patients with high grade gliomas. We report a retrospective multicenter study of 97 consecutive adult patients with anaplastic astrocytoma (AA) treated with radiation therapy (RT) plus concomitant and adjuvant temozolomide (TMZ) between October 2...

journal_title：Journal of neuro-oncology

authors： Minniti G,Scaringi C,Arcella A,Lanzetta G,Di Stefano D,Scarpino S,Bozzao A,Pace A,Villani V,Salvati M,Esposito V,Giangaspero F,Enrici RM

更新日期：2014-06-01 00:00:00

abstract：:High-dose (1-3.5 g/m2) methotrexate (MTX) followed by whole-brain radiation therapy (WBRT) has consistently improved length of survival in primary central nervous system lymphoma (PCNSL), but the prognosis remains dismal. To optimize and enhance the dose intensity of MTX, we applied MTX at 8 g/m2 to 20 patients with P...

journal_title：Journal of neuro-oncology

authors： Watanabe T,Katayama Y,Yoshino A,Komine C,Yokoyama T,Fukushima T

更新日期：2003-05-01 00:00:00

abstract：:The labeling index (LI) of 216 cases of human brain tumors was determined by the immunohistochemical technique with monoclonal antibody to bromodeoxyuridine (BrdU). The proliferative potential of 110 cases was estimated using the intra-operative intravenous infusion of BrdU at a dose of 200 mg/sq m. In another 106 cas...

journal_title：Journal of neuro-oncology

authors： Kharbanda K,Dinda AK,Sarkar C,Karak AK,Dhir R,Mathur M,Roy S

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:Ferumoxtran-10 belongs to the Ultra Small Particles of Iron Oxide (USPIO) class of contrast agents and induces delayed tumor enhancement in brain tumors, reflecting the trapping of iron oxide particles by the macrophages and activated microglia. The aim of the study was to compare Ferumoxtran-10 contrast enhanc...

journal_title：Journal of neuro-oncology

authors： Kremer S,Pinel S,Védrine PO,Bressenot A,Robert P,Bracard S,Plénat F

更新日期：2007-06-01 00:00:00

abstract：:The high incidence of gliomas in Li-Fraumeni families and the high frequency of somatic p53 mutations in sporadic glial tumors have raised the possibility that germline p53 mutations could play an important role in familial aggregation of gliomas. In the present study, 18 families with two or more gliomas were screene...

journal_title：Journal of neuro-oncology

authors： Paunu N,Syrjäkoski K,Sankila R,Simola KO,Helén P,Niemelä M,Matikainen M,Isola J,Haapasalo H

更新日期：2001-12-01 00:00:00

abstract：:Despite the accumulating evidences of high chemosensitivity especially in anaplastic oligodendrogliomas with loss of chromosomes 1p and 19q, the optimal management strategy for low-grade tumors using the 1p/19q information remains controversial. We have treated all low-grade oligodendrogliomas by a chemotherapy-preced...

journal_title：Journal of neuro-oncology

authors： Iwadate Y,Matsutani T,Hasegawa Y,Shinozaki N,Higuchi Y,Saeki N

更新日期：2011-05-01 00:00:00

abstract：:Glioblastoma stands out as the most frequent central nervous system neoplasia, presenting a poor prognosis. The aim of this study was to verify the frequency and clinical significance of the aneuploidy of chromosomes 7 and 10, EGFR amplification, PTEN and TP53 deletions and 1p/19q deficiency in adult patients diagnose...

journal_title：Journal of neuro-oncology

authors： Koshiyama DB,Trevisan P,Graziadio C,Rosa RFM,Cunegatto B,Scholl J,Provenzi VO,de Sá AP,Soares FP,Velho MC,de A P Filho N,Oliveira CA,Zen PRG

更新日期：2017-12-01 00:00:00

abstract：:After the second recurrence of spinal seeding in hemangioblastoma not associated to von-Hippel-Lindau disease, we treated an adult female patient with thalidomide 200 mg orally/day at night for longer than 1 year. The patient reported subjective relief of symptoms after 1 month. Magnetic resonance imaging (MRI) contro...

journal_title：Journal of neuro-oncology

authors： Piribauer M,Czech T,Dieckmann K,Birner P,Hainfellner JA,Prayer D,Fazeny-Dörner B,Weinländer G,Marosi C

更新日期：2004-02-01 00:00:00

abstract：:Central nervous system (brain or leptomeningeal) metastases (BLm) are considered rare in castration-resistant prostate cancer (CRPC) patients. Now that docetaxel has become the reference drug for first-line treatment of CRPC, patients whose disease is not controlled by hormonal manipulations may live much longer than ...

journal_title：Journal of neuro-oncology

authors： Caffo O,Gernone A,Ortega C,Sava T,Cartenì G,Facchini G,Re GL,Amadio P,Bortolus R,Pagliarulo V,Prati V,Veccia A,Galligioni E

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:Outcomes for patients with recurrent high-grade glioma (HGG) progressing on bevacizumab (BEV) are dismal. Fractionated stereotactic radiosurgery (FSRS) has been shown to be feasible and safe when delivered in this setting, but prospective evidence is lacking. This single-institution randomized trial compared FS...

journal_title：Journal of neuro-oncology

authors： Bergman D,Modh A,Schultz L,Snyder J,Mikkelsen T,Shah M,Ryu S,Siddiqui MS,Walbert T

更新日期：2020-06-01 00:00:00

abstract：:Hypermethylation of the MGMT gene promoter and mutation of the TP53 tumor-suppressor gene are frequently present in diffuse astrocytomas. However, there is only anecdotal information about MGMT methylation status and TP53 mutations during progression of low-grade diffuse astrocytoma (AII) to anaplastic astrocytoma (AI...

journal_title：Journal of neuro-oncology

authors： Groenendijk FH,Taal W,Dubbink HJ,Haarloo CR,Kouwenhoven MC,van den Bent MJ,Kros JM,Dinjens WN

更新日期：2011-02-01 00:00:00

abstract：:Cranial radiation can impact the cerebral vasculature in many ways, with a wide range of clinical manifestations. The incidence of these late effects including cerebrovascular accidents (CVAs), lacunar lesions, vascular occlusive disease including moyamoya syndrome, vascular malformations, and hemorrhage is not well k...

journal_title：Journal of neuro-oncology

authors： Murphy ES,Xie H,Merchant TE,Yu JS,Chao ST,Suh JH

更新日期：2015-05-01 00:00:00

abstract：:The authors studied 24 patients affected by anaplastic gliomas in regard to the killer (Antibody-Dependent Cellular Cytotoxicity) and natural killer (Spontaneous Lymphocyte-Mediated Cytotoxicity) immunological functions, by counting the Cr51 release in Change liver and K 562 cell cultures, respectively. These paramete...

journal_title：Journal of neuro-oncology

authors： Servadei F,Parente R,Bucci M,Beltrandi E,Tognetti F,Gaist G

更新日期：1983-01-01 00:00:00