Abstract:
:We isolated Andes virus (formal name: Andes virus [ANDV], a species in the genus Hantavirus), from serum of an asymptomatic 10-year-old Chilean boy who died 6 days later of hantavirus pulmonary syndrome (HPS). The serum was obtained 12 days after his grandmother died from HPS and 2 days before he became febrile. No hantavirus immunoglobulin (Ig) G or IgM antibodies were detected in the serum sample. After three blind passages, ANDV antigens were detected in Vero E6 cells by immunofluorescence assay and enzyme-linked immunosorbent assay, and ANDV RNA was detected by reverse transcription-polymerase chain reaction. A fragment of the virus genome showed 96.2% nucleotide identity with that of prototype ANDV. To our knowledge, this is the first isolation of any agent of hemorrhagic fever with HPS from a human and the first such isolation of hantavirus before symptoms of that syndrome or HPS began.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Galeno H,Mora J,Villagra E,Fernandez J,Hernandez J,Mertz GJ,Ramirez Edoi
10.3201/eid0807.010277subject
Has Abstractpub_date
2002-07-01 00:00:00pages
657-61issue
7eissn
1080-6040issn
1080-6059journal_volume
8pub_type
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