Abstract:
:We report the first genetic characterization of wildtype measles viruses from Uganda. Thirty-six virus isolates from outbreaks in 6 districts were analyzed from 2000 to 2002. Analyses of sequences of the nucleoprotein (N) and hemagglutinin (H) genes showed that the Ugandan isolates were all closely related, and phylogenetic analysis indicated that these viruses were members of a unique group within clade D. Sequences of the Ugandan viruses were not closely related to any of the World Health Organization reference sequences representing the 22 currently recognized genotypes. The minimum nucleotide divergence between the Ugandan viruses and the most closely related reference strain, genotype D2, was 3.1% for the N gene and 2.6% for the H gene. Therefore, Ugandan viruses should be considered a new, proposed genotype (d10). This new sequence information will expand the utility of molecular epidemiologic techniques for describing measles transmission patterns in eastern Africa.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Muwonge A,Nanyunja M,Rota PA,Bwogi J,Lowe L,Liffick SL,Bellini WJ,Sylvester Sdoi
10.3201/eid1110.050431subject
Has Abstractpub_date
2005-10-01 00:00:00pages
1522-6issue
10eissn
1080-6040issn
1080-6059journal_volume
11pub_type
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