Mycobacterium avium in Community and Household Water, Suburban Philadelphia, Pennsylvania, USA, 2010-2012.

Abstract:

:Attention to environmental sources of Mycobacterium avium complex (MAC) infection is a vital component of disease prevention and control. We investigated MAC colonization of household plumbing in suburban Philadelphia, Pennsylvania, USA. We used variable-number tandem-repeat genotyping and whole-genome sequencing with core genome single-nucleotide variant analysis to compare M. avium from household plumbing biofilms with M. avium isolates from patient respiratory specimens. M. avium was recovered from 30 (81.1%) of 37 households, including 19 (90.5%) of 21 M. avium patient households. For 11 (52.4%) of 21 patients with M. avium disease, isolates recovered from their respiratory and household samples were of the same genotype. Within the same community, 18 (85.7%) of 21 M. avium respiratory isolates genotypically matched household plumbing isolates. Six predominant genotypes were recovered across multiple households and respiratory specimens. M. avium colonizing municipal water and household plumbing may be a substantial source of MAC pulmonary infection.

journal_name

Emerg Infect Dis

authors

Lande L,Alexander DC,Wallace RJ Jr,Kwait R,Iakhiaeva E,Williams M,Cameron ADS,Olshefsky S,Devon R,Vasireddy R,Peterson DD,Falkinham JO 3rd

doi

10.3201/eid2503.180336

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

473-481

issue

3

eissn

1080-6040

issn

1080-6059

journal_volume

25

pub_type

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