Abstract:
:Attention to environmental sources of Mycobacterium avium complex (MAC) infection is a vital component of disease prevention and control. We investigated MAC colonization of household plumbing in suburban Philadelphia, Pennsylvania, USA. We used variable-number tandem-repeat genotyping and whole-genome sequencing with core genome single-nucleotide variant analysis to compare M. avium from household plumbing biofilms with M. avium isolates from patient respiratory specimens. M. avium was recovered from 30 (81.1%) of 37 households, including 19 (90.5%) of 21 M. avium patient households. For 11 (52.4%) of 21 patients with M. avium disease, isolates recovered from their respiratory and household samples were of the same genotype. Within the same community, 18 (85.7%) of 21 M. avium respiratory isolates genotypically matched household plumbing isolates. Six predominant genotypes were recovered across multiple households and respiratory specimens. M. avium colonizing municipal water and household plumbing may be a substantial source of MAC pulmonary infection.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Lande L,Alexander DC,Wallace RJ Jr,Kwait R,Iakhiaeva E,Williams M,Cameron ADS,Olshefsky S,Devon R,Vasireddy R,Peterson DD,Falkinham JO 3rddoi
10.3201/eid2503.180336subject
Has Abstractpub_date
2019-03-01 00:00:00pages
473-481issue
3eissn
1080-6040issn
1080-6059journal_volume
25pub_type
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