Abstract:
:Influenza A (H5N1) viruses are strong candidates for causing the next influenza pandemic if they acquire the ability for efficient human-to-human transmission. A major public health goal is to make efficacious vaccines against these viruses by using novel approaches, including cell-culture system, reverse genetics, and adjuvant development. Important consideration for the strategy includes preparation of vaccines from a currently circulating strain to induce broad-spectrum immunity toward newly emerged human H5 strains. This strategy would be a good solution early in a pandemic until an antigenically matched and approved vaccine is produced. The concept of therapeutic vaccines (e.g., antidisease vaccine) directed at diminishing the cytokine storm frequently seen in subtype H5N1-infected persons is underscored. Better understanding of host-virus interaction is essential to identify tools to produce effective vaccines against influenza (H5N1).
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Haque A,Hober D,Kasper LHdoi
10.3201/eid1310.061262subject
Has Abstractpub_date
2007-10-01 00:00:00pages
1512-8issue
10eissn
1080-6040issn
1080-6059journal_volume
13pub_type
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