Abstract:
:Multidrug-resistant strains of Mycobacterium tuberculosis seriously threaten tuberculosis (TB) control and prevention efforts. Molecular studies of the mechanism of action of antitubercular drugs have elucidated the genetic basis of drug resistance in M. tuberculosis. Drug resistance in M. tuberculosis is attributed primarily to the accumulation of mutations in the drug target genes; these mutations lead either to an altered target (e.g., RNA polymerase and catalase-peroxidase in rifampicin and isoniazid resistance, respectively) or to a change in titration of the drug (e.g., InhA in isoniazid resistance). Development of specific mechanism-based inhibitors and techniques to rapidly detect multidrug resistance will require further studies addressing the drug and drug-target interaction.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Rattan A,Kalia A,Ahmad Ndoi
10.3201/eid0402.980207subject
Has Abstractpub_date
1998-04-01 00:00:00pages
195-209issue
2eissn
1080-6040issn
1080-6059journal_volume
4pub_type
杂志文章,评审abstract::After our recent discovery of a Streptococcus pneumoniae 19A "superbug" (Legacy strain) that is resistant to all Food and Drug Administration-approved antimicrobial drugs for treatment of acute otitis media (AOM) in children, other S. pneumoniae isolates from children with AOM were characterized by multilocus sequence...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1504.071704
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journal_title:Emerging infectious diseases
pub_type: 杂志文章
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更新日期:2003-12-01 00:00:00
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journal_title:Emerging infectious diseases
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journal_title:Emerging infectious diseases
pub_type: 共识发展会议,杂志文章
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更新日期:2010-08-01 00:00:00
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journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1010.040382
更新日期:2004-10-01 00:00:00
abstract::Dengue was first reported in Puerto Rico in 1899 and sporadically thereafter. Following outbreaks in 1963 and 1969, the Centers for Disease Control and Prevention has worked closely with the Puerto Rico Department of Health to monitor and reduce the public health burden of dengue. During that time, evolving epidemiolo...
journal_title:Emerging infectious diseases
pub_type: 历史文章,杂志文章
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journal_title:Emerging infectious diseases
pub_type: 杂志文章,评审
doi:10.3201/eid0104.950402
更新日期:1995-10-01 00:00:00
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pub_type: 杂志文章
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journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid2211.151028
更新日期:2016-11-01 00:00:00
abstract::We conducted a retrospective, observational, population-based study to investigate the effect of staphylococcal infections on the hospitalization of children in California during 1985-2009. Hospitalized children with staphylococcal infections were identified through the California Office of Statewide Health Planning a...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1901.111740
更新日期:2013-01-01 00:00:00
abstract::Zika virus is normally transmitted by mosquitos, but cases of sexual transmission have been reported. We describe a patient with symptomatic Zika virus infection in whom the virus was detected in semen for 92 days. Our findings support recommendations for 6 months of barrier contraceptive use after symptomatic Zika vi...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid2301.161300
更新日期:2017-01-01 00:00:00
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journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1206.051324
更新日期:2006-06-01 00:00:00
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journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1307.070063
更新日期:2007-07-01 00:00:00
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journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
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journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1002.030793
更新日期:2004-02-01 00:00:00
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journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid2211.160220
更新日期:2016-11-01 00:00:00
abstract::The role of rats in human hepatitis E virus (HEV) infections remains controversial. A genetically distinct HEV was recently isolated from rats in Germany, and its genome was sequenced. We have isolated a genetically similar HEV from urban rats in Los Angeles, California, USA, and characterized its ability to infect la...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1712.110482
更新日期:2011-12-01 00:00:00
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journal_title:Emerging infectious diseases
pub_type: 历史文章,杂志文章
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更新日期:2019-06-01 00:00:00
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journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid2102.140961
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journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1708.110201
更新日期:2011-08-01 00:00:00
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journal_title:Emerging infectious diseases
pub_type: 杂志文章
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更新日期:2018-11-01 00:00:00
abstract::An outbreak of ulcerative stomatitis was observed in a donkey (Equus asinus) dairy herd. Similar lesions were also observed on the dams' udders and, sporadically, in genital areas. The lesions typically resolved in 1-3 weeks. An α-herpesvirus, Varicellovirus, genetically related to equid herpesvirus type 3, was identi...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid2612.200201
更新日期:2020-12-01 00:00:00
abstract::Leishmaniasis is a zoonotic disease caused by predominantly vectorborne Leishmania spp. In the United States, canine visceral leishmaniasis is common among hounds, and L. infantum vertical transmission among hounds has been confirmed. We found that L. infantum from hounds remains infective in sandflies, underscoring t...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid2112.141167
更新日期:2015-12-01 00:00:00
abstract::Directors of all major BioSafety Level 4 (BSL-4) laboratories in the United States met in 2008 to review the current status of biocontainment laboratory operations and to discuss the potential impact of a proposed 2-person security rule on maximum-containment laboratory operations. Special attention was paid to the va...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1507.081523
更新日期:2009-07-01 00:00:00
abstract::Guidelines available to school administrators to support school closure decisions during influenza outbreaks are usually not evidence-based. Using empirical data on absentee rates of elementary school students in Japan, we developed a simple and practical algorithm for determining the optimal timing of school closures...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:
更新日期:2009-11-01 00:00:00
abstract::Lassa virus, the cause of Lassa fever in humans, is endemic to West Africa. Treatment of Lassa fever is primarily supportive, although ribavirin has shown limited efficacy if administered early during infection. We tested favipiravir in Lassa virus-viremic macaques and found that 300 mg/kg daily for 2 weeks successful...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
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journal_title:Emerging infectious diseases
pub_type: 杂志文章
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更新日期:2004-02-01 00:00:00
abstract::A decision analytical model was developed to investigate the cost-effectiveness of stockpiling antiviral (AV) drugs for a potential influenza pandemic in the United Kingdom and the possible role of near-patient testing in conserving AV drug stocks. Under base-case assumptions (including a fixed stockpile that was smal...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1402.070478
更新日期:2008-02-01 00:00:00
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journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid0901.020266
更新日期:2003-01-01 00:00:00