Multidrug-resistant Mycobacterium tuberculosis: molecular perspectives.

Abstract:

:Multidrug-resistant strains of Mycobacterium tuberculosis seriously threaten tuberculosis (TB) control and prevention efforts. Molecular studies of the mechanism of action of antitubercular drugs have elucidated the genetic basis of drug resistance in M. tuberculosis. Drug resistance in M. tuberculosis is attributed primarily to the accumulation of mutations in the drug target genes; these mutations lead either to an altered target (e.g., RNA polymerase and catalase-peroxidase in rifampicin and isoniazid resistance, respectively) or to a change in titration of the drug (e.g., InhA in isoniazid resistance). Development of specific mechanism-based inhibitors and techniques to rapidly detect multidrug resistance will require further studies addressing the drug and drug-target interaction.

journal_name

Emerg Infect Dis

authors

Rattan A,Kalia A,Ahmad N

doi

10.3201/eid0402.980207

subject

Has Abstract

pub_date

1998-04-01 00:00:00

pages

195-209

issue

2

eissn

1080-6040

issn

1080-6059

journal_volume

4

pub_type

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