Abstract:
:The role of rats in human hepatitis E virus (HEV) infections remains controversial. A genetically distinct HEV was recently isolated from rats in Germany, and its genome was sequenced. We have isolated a genetically similar HEV from urban rats in Los Angeles, California, USA, and characterized its ability to infect laboratory rats and nonhuman primates. Two strains of HEV were isolated from serum samples of 134 wild rats that had a seroprevalence of antibodies against HEV of ≈80%. Virus was transmissible to seronegative Sprague-Dawley rats, but transmission was spotty and magnitude and duration of infection were not robust. Viremia was higher in nude rats. Serologic analysis and reverse transcription PCR were comparably sensitive in detecting infection. The sequence of the Los Angeles virus was virtually identical to that of isolates from Germany. Rat HEV was not transmissible to rhesus monkeys, suggesting that it is not a source of human infection.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Purcell RH,Engle RE,Rood MP,Kabrane-Lazizi Y,Nguyen HT,Govindarajan S,St Claire M,Emerson SUdoi
10.3201/eid1712.110482subject
Has Abstractpub_date
2011-12-01 00:00:00pages
2216-22issue
12eissn
1080-6040issn
1080-6059journal_volume
17pub_type
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