Abstract:
:Variant Creutzfeldt-Jakob disease (vCJD) may be transmissible by blood. To prevent secondary transmission through blood components, several countries have started to exclude as donors persons who have received a blood transfusion. We investigated the effectiveness of this measure by using a dynamic age-structured model. It is the first such model based on epidemiologic data: 1) blood donor activities, 2) a case-control study on CJD, 3) age distribution of recipients, and 4) death of recipients of blood transfusions. The model predicts that an infection like vCJD, which has been introduced into the population by the alimentary route, could not become endemic by transfusion alone and that only <1% of cases would be avoided by excluding from blood donation those persons who have received a transfusion.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Dietz K,Raddatz G,Wallis J,Müller N,Zerr I,Duerr HP,Lefèvre H,Seifried E,Löwer Jdoi
10.3201/eid1301.060396subject
Has Abstractpub_date
2007-01-01 00:00:00pages
89-96issue
1eissn
1080-6040issn
1080-6059journal_volume
13pub_type
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