Abstract:
:False-negative results for Plasmodium falciparum histidine-rich protein (HRP) 2-based rapid diagnostic tests (RDTs) are increasing in Eritrea. We investigated HRP gene 2/3 (pfhrp2/pfhrp3) status in 50 infected patients at 2 hospitals. We showed that 80.8% (21/26) of patients at Ghindae Hospital and 41.7% (10/24) at Massawa Hospital were infected with pfhrp2-negative parasites and 92.3% (24/26) of patients at Ghindae Hospital and 70.8% (17/24) at Massawa Hospital were infected with pfhrp3-negative parasites. Parasite densities between pfhrp2-positive and pfhrp2-negative patients were comparable. All pfhrp2-negative samples had no detectable HRP2/3 antigen and showed negative results for HRP2-based RDTs. pfhrp2-negative parasites were genetically less diverse and formed 2 clusters with no close relationships to parasites from Peru. These parasites probably emerged independently by selection in Eritrea. High prevalence of pfhrp2-negative parasites caused a high rate of false-negative results for RDTs. Determining prevalence of pfhrp2-negative parasites is urgently needed in neighboring countries to assist case management policies.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Berhane A,Anderson K,Mihreteab S,Gresty K,Rogier E,Mohamed S,Hagos F,Embaye G,Chinorumba A,Zehaie A,Dowd S,Waters NC,Gatton ML,Udhayakumar V,Cheng Q,Cunningham Jdoi
10.3201/eid2403.171723subject
Has Abstractpub_date
2018-03-01 00:00:00pages
462-470issue
3eissn
1080-6040issn
1080-6059journal_volume
24pub_type
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