Novel thogotovirus associated with febrile illness and death, United States, 2014.

Abstract:

:A previously healthy man from eastern Kansas, USA, sought medical care in late spring because of a history of tick bite, fever, and fatigue. The patient had thrombocytopenia and leukopenia and was given doxycycline for a presumed tickborne illness. His condition did not improve. Multiorgan failure developed, and he died 11 days after illness onset from cardiopulmonary arrest. Molecular and serologic testing results for known tickborne pathogens were negative. However, testing of a specimen for antibodies against Heartland virus by using plaque reduction neutralization indicated the presence of another virus. Next-generation sequencing and phylogenetic analysis identified the virus as a novel member of the genus Thogotovirus.

journal_name

Emerg Infect Dis

authors

Kosoy OI,Lambert AJ,Hawkinson DJ,Pastula DM,Goldsmith CS,Hunt DC,Staples JE

doi

10.3201/eid2105.150150

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

760-4

issue

5

eissn

1080-6040

issn

1080-6059

journal_volume

21

pub_type

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