Abstract:
:We used whole-genome sequence typing (WGST) to investigate an outbreak of Sarocladium kiliense bloodstream infections (BSI) associated with receipt of contaminated antinausea medication among oncology patients in Colombia and Chile during 2013-2014. Twenty-five outbreak isolates (18 from patients and 7 from medication vials) and 11 control isolates unrelated to this outbreak were subjected to WGST to elucidate a source of infection. All outbreak isolates were nearly indistinguishable (<5 single-nucleotide polymorphisms), and >21,000 single-nucleotide polymorphisms were identified from unrelated control isolates, suggesting a point source for this outbreak. S. kiliense has been previously implicated in healthcare-related infections; however, the lack of available typing methods has precluded the ability to substantiate point sources. WGST for outbreak investigation caused by eukaryotic pathogens without reference genomes or existing genotyping methods enables accurate source identification to guide implementation of appropriate control and prevention measures.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Etienne KA,Roe CC,Smith RM,Vallabhaneni S,Duarte C,Escadon P,Castaneda E,Gomez BL,de Bedout C,López LF,Salas V,Hederra LM,Fernandez J,Pidal P,Hormazabel JC,Otaiza F,Vannberg FO,Gillece J,Lemmer D,Driebe EM,Englethdoi
10.3201/eid2203.151193subject
Has Abstractpub_date
2016-03-01 00:00:00pages
476-81issue
3eissn
1080-6040issn
1080-6059journal_volume
22pub_type
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