Abstract:
:Despite the recent global spread of CTX-M beta-lactamases in Escherichia coli isolates from community-acquired urinary tract infections (CA-UTIs), their dissemination has been little studied in developing countries. In a 2-year prospective study, we documented the prevalence of extended-spectrum beta-lactamases (ESBLs) in E. coli that were responsible for CA-UTIs in Phnom-Penh, Cambodia. Ninety-three E. coli strains were included. We observed a high prevalence of resistance to amoxicillin (88.2% of strains), cotrimoxazole (75.3%), ciprofloxacin (67.7%), gentamicin (42.5%), and third-generation cephalosporins (37.7%). A total of 34 strains carried ESBLs, all of which were CTX-M type. CTX-M carriage was associated with resistance to fluoroquinolones and aminoglycosides. U using repetitive extragenic palindromic-PCR, we identified 4 clusters containing 9, 8, 3, and 2 strains. The prevalence of CTX-M beta-lactamases has reached a critical level in Cambodia, which highlights the need for study of their spread in developing countries.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Ruppé E,Hem S,Lath S,Gautier V,Ariey F,Sarthou JL,Monchy D,Arlet Gdoi
10.3201/eid1505.071299subject
Has Abstractpub_date
2009-05-01 00:00:00pages
741-8issue
5eissn
1080-6040issn
1080-6059journal_volume
15pub_type
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