Abstract:
:Human bocavirus (HBoV) is a widespread respiratory virus. To improve diagnostic methods, we conducted immunoglobulin (Ig) G and IgM enzyme immunoassays with recombinant virus-like particles of HBoV as antigen. Acute-phase and follow-up serum samples from 258 wheezing children and single serum samples from 115 healthy adults in Finland were examined. Our assays had a sensitivity of 97% and a specificity of 99.5%. Of adults, 96% had immunity; none had an acute infection. Of 48 children with serologically diagnosed acute HBoV infections, 45 were viremic and 35 had virus in nasopharyngeal aspirates (NPAs). Of 39 HBoV NPA PCR-positive children co-infected with another virus, 64% had a serologically verified HBoV infection. HBoV caused illness of longer duration than rhinovirus and of equal severity to that of respiratory syncytial virus. Among children with bronchiolitis, >25% had acute HBoV infections. Accurate HBoV diagnosis requires serologic analysis or PCR of serum; PCR of NPAs alone is insufficient.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Söderlund-Venermo M,Lahtinen A,Jartti T,Hedman L,Kemppainen K,Lehtinen P,Allander T,Ruuskanen O,Hedman Kdoi
10.3201/eid1509.090204subject
Has Abstractpub_date
2009-09-01 00:00:00pages
1423-30issue
9eissn
1080-6040issn
1080-6059journal_volume
15pub_type
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