Abstract:
:Middle East respiratory syndrome coronavirus (MERS-CoV) infections in humans can cause asymptomatic to fatal lower respiratory lung disease. Despite posing a probable risk for virus transmission, asymptomatic to mild infections can go unnoticed; a lack of seroconversion among some PCR-confirmed cases has been reported. We found that a MERS-CoV spike S1 protein-based ELISA, routinely used in surveillance studies, showed low sensitivity in detecting infections among PCR-confirmed patients with mild clinical symptoms and cross-reactivity of human coronavirus OC43-positive serum samples. Using in-house S1 ELISA and protein microarray, we demonstrate that most PCR-confirmed MERS-CoV case-patients with mild infections seroconverted; nonetheless, some of these samples did not have detectable levels of virus-neutralizing antibodies. The use of a sensitive and specific serologic S1-based assay can be instrumental in the accurate estimation of MERS-CoV prevalence.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Okba NMA,Raj VS,Widjaja I,GeurtsvanKessel CH,de Bruin E,Chandler FD,Park WB,Kim NJ,Farag EABA,Al-Hajri M,Bosch BJ,Oh MD,Koopmans MPG,Reusken CBEM,Haagmans BLdoi
10.3201/eid2510.190051subject
Has Abstractpub_date
2019-10-01 00:00:00pages
1868-1877issue
10eissn
1080-6040issn
1080-6059journal_volume
25pub_type
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