Abstract:
:In 1988, the World Health Assembly launched the Global Polio Eradication Initiative, which aimed to use large-scale vaccination with the oral vaccine to eradicate polio worldwide by the year 2000. Although important progress has been made, polio remains endemic in several countries. Also, the current control measures will likely be inadequate to deal with problems that may arise in the postpolio era. A panel convoked by the National Research Council concluded that the use of antiviral drugs may be essential in the polio eradication strategy. We here report on a comparative study of the antipoliovirus activity of a selection of molecules that have previously been reported to be inhibitors of picornavirus replication and discuss their potential use, alone or in combination, for the treatment or prophylaxis of poliovirus infection.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
De Palma AM,Pürstinger G,Wimmer E,Patick AK,Andries K,Rombaut B,De Clercq E,Neyts Jdoi
10.3201/eid1404.070439subject
Has Abstractpub_date
2008-04-01 00:00:00pages
545-51issue
4eissn
1080-6040issn
1080-6059journal_volume
14pub_type
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