Healthcare worker occupation and immune response to Pneumocystis jirovecii.

Abstract:

:The reservoir and mode of transmission of Pneumocystis jirovecii remain uncertain. We conducted a cross-sectional study of 126 San Francisco General Hospital staff in clinical (n = 103) and nonclinical (n = 23) occupations to assess whether occupational exposure was associated with immune responses to P. jirovecii. We examined antibody levels by ELISA for 3 overlapping fragments that span the P. jirovecii major surface glycoprotein (Msg): MsgA, MsgB, and MsgC1. Clinical occupation participants had higher geometric mean antibody levels to MsgC1 than did nonclinical occupation participants (21.1 vs. 8.2, p = 0.004); clinical occupation was an independent predictor of higher MsgC1 antibody levels (parameter estimate = 0.89, 95% confidence interval 0.29-1.48, p = 0.003). In contrast, occupation was not significantly associated with antibody responses to either MsgA or MsgB. Healthcare workers may have occupational exposure to P. jirovecii. Humans may be a reservoir for P. jirovecii and may transmit it from person to person.

journal_name

Emerg Infect Dis

authors

Tipirneni R,Daly KR,Jarlsberg LG,Koch JV,Swartzman A,Roth BM,Walzer PD,Huang L

doi

10.3201/eid1510.090207

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

1590-7

issue

10

eissn

1080-6040

issn

1080-6059

journal_volume

15

pub_type

杂志文章
  • New alphacoronavirus in Mystacina tuberculata bats, New Zealand.

    abstract::Because of recent interest in bats as reservoirs of emerging diseases, we investigated the presence of viruses in Mystacina tuberculata bats in New Zealand. A novel alphacoronavirus sequence was detected in guano from roosts of M. tuberculata bats in pristine indigenous forest on a remote offshore island (Codfish Isla...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2004.131441

    authors: Hall RJ,Wang J,Peacey M,Moore NE,McInnes K,Tompkins DM

    更新日期:2014-04-01 00:00:00

  • Invasive Nontuberculous Mycobacterial Infections among Cardiothoracic Surgical Patients Exposed to Heater-Cooler Devices1.

    abstract::Invasive nontuberculous mycobacteria (NTM) infections may result from a previously unrecognized source of transmission, heater-cooler devices (HCDs) used during cardiac surgery. In July 2015, the Pennsylvania Department of Health notified the Centers for Disease Control and Prevention (CDC) about a cluster of NTM infe...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2305.161899

    authors: Lyman MM,Grigg C,Kinsey CB,Keckler MS,Moulton-Meissner H,Cooper E,Soe MM,Noble-Wang J,Longenberger A,Walker SR,Miller JR,Perz JF,Perkins KM

    更新日期:2017-05-01 00:00:00

  • Advanced age a risk factor for illness temporally associated with yellow fever vaccination.

    abstract::In 1998, the Centers for Disease Control and Prevention was notified of severe illnesses and one death, temporally associated with yellow fever (YF) vaccination, in two elderly U.S. residents. Because the cases were unusual and adverse events following YF vaccination had not been studied, we estimated age-related repo...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid0706.010605

    authors: Martin M,Weld LH,Tsai TF,Mootrey GT,Chen RT,Niu M,Cetron MS,GeoSentinel Yellow Fever Working Group.

    更新日期:2001-11-01 00:00:00

  • Human parechovirus 3 and neonatal infections.

    abstract::A third serotype of human parechovirus (HPeV) has been recently isolated from stool specimens of a young Japanese child with transient paralysis. We report 3 additional cases of neonatal sepsis caused by HPeV-3 in the fall of 2001 in Canadian infants 7-27 days old. All children were hospitalized with high fever, eryth...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1101.040606

    authors: Boivin G,Abed Y,Boucher FD

    更新日期:2005-01-01 00:00:00

  • Human bocavirus in patients with encephalitis, Sri Lanka, 2009-2010.

    abstract::We identified human bocavirus (HBoV) DNA by PCR in cerebrospinal fluid from adults and children with encephalitis in Sri Lanka. HBoV types 1, 2, and 3 were identified among these cases. Phylogenetic analysis of HBoV1 strain sequences found no subclustering with strains previously identified among encephalitis cases in...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1911.121548

    authors: Mori D,Ranawaka U,Yamada K,Rajindrajith S,Miya K,Perera HK,Matsumoto T,Dassanayake M,Mitui MT,Mori H,Nishizono A,Söderlund-Venermo M,Ahmed K

    更新日期:2013-11-01 00:00:00

  • Mathematical Modeling of Programmatic Requirements for Yaws Eradication.

    abstract::Yaws is targeted for eradication by 2020. The mainstay of the eradication strategy is mass treatment followed by case finding. Modeling has been used to inform programmatic requirements for other neglected tropical diseases and could provide insights into yaws eradication. We developed a model of yaws transmission var...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2301.160487

    authors: Marks M,Mitjà O,Fitzpatrick C,Asiedu K,Solomon AW,Mabey DC,Funk S

    更新日期:2017-01-01 00:00:00

  • Wildlife as source of zoonotic infections.

    abstract::Zoonoses with a wildlife reservoir represent a major public health problem, affecting all continents. Hundreds of pathogens and many different transmission modes are involved, and many factors influence the epidemiology of the various zoonoses. The importance and recognition of wildlife as a reservoir of zoonoses are ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章,评审

    doi:10.3201/eid1012.040707

    authors: Kruse H,kirkemo AM,Handeland K

    更新日期:2004-12-01 00:00:00

  • Malaria risk in travelers.

    abstract::Imported malaria has been an increasing problem in several Western countries in the last 2 decades. To calculate the risk factors of age, sex, and travel destination in Swedish travelers, we used data from the routine reporting system for malaria (mixture of patients with and without adequate prophylaxis), a database ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1103.040677

    authors: Askling HH,Nilsson J,Tegnell A,Janzon R,Ekdahl K

    更新日期:2005-03-01 00:00:00

  • Persistent Bacillus cereus Bacteremia in 3 Persons Who Inject Drugs, San Diego, California, USA.

    abstract::Bacillus cereus is typically considered a blood culture contaminant; however, its presence in blood cultures can indicate true bacteremia. We report 4 episodes of B. cereus bacteremia in 3 persons who inject drugs. Multilocus sequence typing showed that the temporally associated infections were caused by unrelated clo...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2209.150647

    authors: Schaefer G,Campbell W,Jenks J,Beesley C,Katsivas T,Hoffmaster A,Mehta SR,Reed S

    更新日期:2016-09-01 00:00:00

  • Genome sequence conservation of Hendra virus isolates during spillover to horses, Australia.

    abstract::Bat-to-horse transmission of Hendra virus has occurred at least 14 times. Although clinical signs in horses have differed, genome sequencing has demonstrated little variation among the isolates. Our sequencing of 5 isolates from recent Hendra virus outbreaks in horses found no correlation between sequences and time or...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1611.100501

    authors: Marsh GA,Todd S,Foord A,Hansson E,Davies K,Wright L,Morrissy C,Halpin K,Middleton D,Field HE,Daniels P,Wang LF

    更新日期:2010-11-01 00:00:00

  • Genetic characterization of hantaviruses transmitted by the Korean field mouse (Apodemus peninsulae), Far East Russia.

    abstract::In an epizootiologic survey of 122 rodents captured in Vladivostok, Russia, antibodies positive for hantavirus were found in Apodemus peninsulae (4/70), A. agrarius (1/39), and Clethrionomys rufocanus (1/8). The hantavirus sequences identified in two seropositive A. peninsulae and two patients with hemorrhagic fever w...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid0808.010494

    authors: Lokugamage K,Kariwa H,Hayasaka D,Cui BZ,Iwasaki T,Lokugamage N,Ivanov LI,Volkov VI,Demenev VA,Slonova R,Kompanets G,Kushnaryova T,Kurata T,Maeda K,Araki K,Mizutani T,Yoshimatsu K,Arikawa J,Takashima I

    更新日期:2002-08-01 00:00:00

  • Antimicrobial Resistance in Invasive Bacterial Infections in Hospitalized Children, Cambodia, 2007-2016.

    abstract::To determine trends, mortality rates, and costs of antimicrobial resistance in invasive bacterial infections in hospitalized children, we analyzed data from Angkor Hospital for Children, Siem Reap, Cambodia, for 2007-2016. A total of 39,050 cultures yielded 1,341 target pathogens. Resistance rates were high; 82% each ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2405.171830

    authors: Fox-Lewis A,Takata J,Miliya T,Lubell Y,Soeng S,Sar P,Rith K,McKellar G,Wuthiekanun V,McGonagle E,Stoesser N,Moore CE,Parry CM,Turner C,Day NPJ,Cooper BS,Turner P

    更新日期:2018-05-01 00:00:00

  • Blood transfusion and spread of variant Creutzfeldt-Jakob disease.

    abstract::Variant Creutzfeldt-Jakob disease (vCJD) may be transmissible by blood. To prevent secondary transmission through blood components, several countries have started to exclude as donors persons who have received a blood transfusion. We investigated the effectiveness of this measure by using a dynamic age-structured mode...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1301.060396

    authors: Dietz K,Raddatz G,Wallis J,Müller N,Zerr I,Duerr HP,Lefèvre H,Seifried E,Löwer J

    更新日期:2007-01-01 00:00:00

  • Multidrug-resistant Acinetobacter extremity infections in soldiers.

    abstract::War wound infection and osteomyelitis caused by multidrug-resistant (MDR) Acinetobacter species have been prevalent during the 2003-2005 military operations in Iraq. Twenty-three soldiers wounded in Iraq and subsequently admitted to our facility from March 2003 to May 2004 had wound cultures positive for Acinetobacter...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/1108.050103

    authors: Davis KA,Moran KA,McAllister CK,Gray PJ

    更新日期:2005-08-01 00:00:00

  • Antibody-based therapies for emerging infectious diseases.

    abstract::In the 19th century, it was discovered that immune sera were useful in treating infectious diseases. Serum therapy was largely abandoned in the 1940s because of the toxicity associated with the administration of heterologous sera and the introduction of effective antimicrobial chemotherapy. Recent advances in the tech...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章,评审

    doi:10.3201/eid0203.960306

    authors: Casadevall A

    更新日期:1996-07-01 00:00:00

  • Outbreak of Tuberculosis and Multidrug-Resistant Tuberculosis, Mbuji-Mayi Central Prison, Democratic Republic of the Congo.

    abstract::After an alert regarding ≈31 tuberculosis (TB) cases, 3 of which were rifampin-resistant TB cases, in Mbuji-Mayi Central Prison, Democratic Republic of the Congo, we conducted an outbreak investigation in January 2015. We analyzed sputum of presumptive TB patients by using the Xpert MTB/RIF assay. We also assessed the...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2411.180769

    authors: Kayomo MK,Hasker E,Aloni M,Nkuku L,Kazadi M,Kabengele T,Muteteke D,Kapita F,Lufulwabo A,Mukadi YD,Muyembe-Tamfum JJ,Ieven M,de Jong BC,Boelaert M

    更新日期:2018-11-01 00:00:00

  • Surface antigens of the syphilis spirochete and their potential as virulence determinants.

    abstract::A unique physical feature of Treponema pallidum, the venereally transmitted agent of human syphilis, is that its outer membrane contains 100-fold less membrane-spanning protein than the outer membranes of typical gram-negative bacteria, a property that has been related to the chronicity of syphilitic infection. These ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章,评审

    doi:10.3201/eid0301.970102

    authors: Blanco DR,Miller JN,Lovett MA

    更新日期:1997-01-01 00:00:00

  • Primary amebic meningoencephalitis caused by Naegleria fowleri, Karachi, Pakistan.

    abstract::We report 13 cases of Naegleria fowleri primary amebic meningoencephalitis in persons in Karachi, Pakistan, who had no history of aquatic activities. Infection likely occurred through ablution with tap water. An increase in primary amebic meningoencephalitis cases may be attributed to rising temperatures, reduced leve...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1702.100442

    authors: Shakoor S,Beg MA,Mahmood SF,Bandea R,Sriram R,Noman F,Ali F,Visvesvara GS,Zafar A

    更新日期:2011-02-01 00:00:00

  • Scrub typhus in Himalayas.

    abstract::Himachal Pradesh state of India is situated in the outer Himalayan ranges. During the rainy season, several cases of acute febrile illness of unknown origin occurred. Orientia tsutsugamushi was identified as the causative agent by microimmunofluorescence and PCR. Two new genotypes of O. tsutsugamushi were identified i...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1210.051697

    authors: Mahajan SK,Rolain JM,Kashyap R,Bakshi D,Sharma V,Prasher BS,Pal LS,Raoult D

    更新日期:2006-10-01 00:00:00

  • Potential Fifth Clade of Candida auris, Iran, 2018.

    abstract::Four major clades of Candida auris have been described, and all infections have clustered in these 4 clades. We identified an isolate representative of a potential fifth clade, separated from the other clades by >200,000 single-nucleotide polymorphisms, in a patient in Iran who had never traveled outside the country. ...

    journal_title:Emerging infectious diseases

    pub_type: 信件

    doi:10.3201/eid2509.190686

    authors: Chow NA,de Groot T,Badali H,Abastabar M,Chiller TM,Meis JF

    更新日期:2019-09-01 00:00:00

  • Clinical Isolation and Identification of Haematospirillum jordaniae.

    abstract::A clinical case study involving a man (35-49 years of age) with wounds to his lower right extremity. An isolate was sent to the Delaware Public Health Laboratory for confirmatory testing by genetic analysis of the 16S gene. Testing identified the isolate as a novel genus and species, Haematospirillum jordaniae. ...

    journal_title:Emerging infectious diseases

    pub_type: 信件

    doi:10.3201/eid2410.180548

    authors: Hovan G,Hollinger A

    更新日期:2018-10-01 00:00:00

  • Pesticides and public health: integrated methods of mosquito management.

    abstract::Pesticides have a role in public health as part of sustainable integrated mosquito management. Other components of such management include surveillance, source reduction or prevention, biological control, repellents, traps, and pesticide-resistance management. We assess the future use of mosquito control pesticides in...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid0701.010103

    authors: Rose RI

    更新日期:2001-01-01 00:00:00

  • Oseltamivir-resistant influenza A(H1N1)pdm09 viruses, United States, 2013-14.

    abstract::We report characteristics of oseltamivir-resistant influenza A(H1N1)pdm09 viruses and patients infected with these viruses in the United States. During 2013-14, fifty-nine (1.2%) of 4,968 analyzed US influenza A(H1N1)pdm09 viruses had the H275Y oseltamivir resistance-conferring neuraminidase substitution. Our results ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2101.141006

    authors: Okomo-Adhiambo M,Fry AM,Su S,Nguyen HT,Elal AA,Negron E,Hand J,Garten RJ,Barnes J,Xiyan X,Villanueva JM,Gubareva LV,2013–14 US Influenza Antiviral Working Group.

    更新日期:2015-01-01 00:00:00

  • New technology for detecting multidrug-resistant pathogens in the clinical microbiology laboratory.

    abstract::Northwestern Memorial Hospital instituted in-house molecular typing to rapidly assess microbial clonality and integrated this typing into an infection control program. We compared data on nosocomial infections collected during 24 months before and 60 months after implementing the new program. During the intervention p...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章,评审

    doi:10.3201/eid0702.010233

    authors: Peterson LR,Noskin GA

    更新日期:2001-03-01 00:00:00

  • Loiasis in US Traveler Returning from Bioko Island, Equatorial Guinea, 2016.

    abstract::The filarial parasite Loa loa overlaps geographically with Onchocera volvulus and Wuchereria bancrofti filariae in central Africa. Accurate information regarding this overlap is critical to elimination programs targeting O. volvulus and W. bancrofti. We describe a case of loiasis in a traveler returning from Bioko Isl...

    journal_title:Emerging infectious diseases

    pub_type: 信件

    doi:10.3201/eid2301.161427

    authors: Priest DH,Nutman TB

    更新日期:2017-01-01 00:00:00

  • Strategy to enhance influenza surveillance worldwide.

    abstract::The emergence of a novel strain of influenza virus A (H1N1) in April 2009 focused attention on influenza surveillance capabilities worldwide. In consultations before the 2009 outbreak of influenza subtype H1N1, the World Health Organization had concluded that the world was unprepared to respond to an influenza pandemi...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1508.081422

    authors: Ortiz JR,Sotomayor V,Uez OC,Oliva O,Bettels D,McCarron M,Bresee JS,Mounts AW

    更新日期:2009-08-01 00:00:00

  • Myocarditis Outbreak among Adults, Illinois, 2003.

    abstract::An outbreak of myocarditis occurred among adults in Illinois in 2003. Diagnostic testing of myocardial tissues from 3 patients and comprehensive tests for enterovirus and adenovirus of other specimens from patients were inconclusive. Appropriate specimen collection from patients with idiopathic cardiomyopathy and furt...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1110.041152

    authors: Huhn GD,Gross C,Schnurr D,Preas C,Yagi S,Reagan S,Paddock C,Passaro D,Dworkin MS

    更新日期:2005-10-01 00:00:00

  • Mycobacterium chimaera Pulmonary Disease in Cystic Fibrosis Patients, France, 2010-2017.

    abstract::We report Mycobacterium chimaera pulmonary disease in 4 patients given a diagnosis of cystic fibrosis in a university hospital in Montpellier, France. All patients had M. chimaera-positive expectorated sputum specimens, clinical symptoms of pulmonary exacerbation, or a decrease in spirometry test results that improved...

    journal_title:Emerging infectious diseases

    pub_type: 历史文章,信件

    doi:10.3201/eid2503.181590

    authors: Larcher R,Lounnas M,Dumont Y,Michon AL,Bonzon L,Chiron R,Carriere C,Klouche K,Godreuil S

    更新日期:2019-03-01 00:00:00

  • Primary care surveillance for acute bloody diarrhea, Wales.

    abstract::A sentinel group of primary-care physicians in Wales actively reported cases of acute bloody diarrhea from February 1997 through December 1998. The estimated annual rate was 18 cases per 100,000 population. Most (80%) cases were due to Campylobacter or Salmonella; however, 18% were undiagnosed. ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid0604.000418

    authors: Chalmers RM,Salmon RL

    更新日期:2000-07-01 00:00:00

  • Antibiotic resistance of gram-negative bacteria in rivers, United States.

    abstract::Bacteria with intrinsic resistance to antibiotics are found in nature. Such organisms may acquire additional resistance genes from bacteria introduced into soil or water, and the resident bacteria may be the reservoir or source of widespread resistant organisms found in many environments. We isolated antibiotic-resist...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid0807.010264

    authors: Ash RJ,Mauck B,Morgan M

    更新日期:2002-07-01 00:00:00