Abstract:
:The reservoir and mode of transmission of Pneumocystis jirovecii remain uncertain. We conducted a cross-sectional study of 126 San Francisco General Hospital staff in clinical (n = 103) and nonclinical (n = 23) occupations to assess whether occupational exposure was associated with immune responses to P. jirovecii. We examined antibody levels by ELISA for 3 overlapping fragments that span the P. jirovecii major surface glycoprotein (Msg): MsgA, MsgB, and MsgC1. Clinical occupation participants had higher geometric mean antibody levels to MsgC1 than did nonclinical occupation participants (21.1 vs. 8.2, p = 0.004); clinical occupation was an independent predictor of higher MsgC1 antibody levels (parameter estimate = 0.89, 95% confidence interval 0.29-1.48, p = 0.003). In contrast, occupation was not significantly associated with antibody responses to either MsgA or MsgB. Healthcare workers may have occupational exposure to P. jirovecii. Humans may be a reservoir for P. jirovecii and may transmit it from person to person.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Tipirneni R,Daly KR,Jarlsberg LG,Koch JV,Swartzman A,Roth BM,Walzer PD,Huang Ldoi
10.3201/eid1510.090207subject
Has Abstractpub_date
2009-10-01 00:00:00pages
1590-7issue
10eissn
1080-6040issn
1080-6059journal_volume
15pub_type
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