Abstract:
:To determine trends, mortality rates, and costs of antimicrobial resistance in invasive bacterial infections in hospitalized children, we analyzed data from Angkor Hospital for Children, Siem Reap, Cambodia, for 2007-2016. A total of 39,050 cultures yielded 1,341 target pathogens. Resistance rates were high; 82% each of Escherichia coli and Klebsiella pneumoniae isolates were multidrug resistant. Hospital-acquired isolates were more often resistant than community-acquired isolates; resistance trends over time were heterogeneous. K. pneumoniae isolates from neonates were more likely than those from nonneonates to be resistant to ampicillin-gentamicin and third-generation cephalosporins. In patients with community-acquired gram-negative bacteremia, third-generation cephalosporin resistance was associated with increased mortality rates, increased intensive care unit admissions, and 2.26-fold increased healthcare costs among survivors. High antimicrobial resistance in this setting is a threat to human life and the economy. In similar low-resource settings, our methods could be reproduced as a robust surveillance model for antimicrobial resistance.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Fox-Lewis A,Takata J,Miliya T,Lubell Y,Soeng S,Sar P,Rith K,McKellar G,Wuthiekanun V,McGonagle E,Stoesser N,Moore CE,Parry CM,Turner C,Day NPJ,Cooper BS,Turner Pdoi
10.3201/eid2405.171830subject
Has Abstractpub_date
2018-05-01 00:00:00pages
841-851issue
5eissn
1080-6040issn
1080-6059journal_volume
24pub_type
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