Sulfa resistance and dihydropteroate synthase mutants in recurrent Pneumocystis carinii pneumonia.

Abstract:

:Failure of sulfa or sulfone prophylaxis is associated with mutations in Pneumocystis carinii gene coding for dihydropteroate synthase (DHPS). The DHPS genotype was analyzed in AIDS patients who had two separate episodes of P. carinii pneumonia. The results suggest that DHPS mutations can be selected de novo within patients by the pressure of a sulfa or sulfone drug.

journal_name

Emerg Infect Dis

authors

Nahimana A,Rabodonirina M,Helweg-Larsen J,Meneau I,Francioli P,Bille J,Hauser PM

doi

10.3201/eid0907.030249

subject

Has Abstract

pub_date

2003-07-01 00:00:00

pages

864-7

issue

7

eissn

1080-6040

issn

1080-6059

journal_volume

9

pub_type

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