Cost-effectiveness of a potential vaccine for human papillomavirus.

Abstract:

:Human papillomavirus (HPV) infection, usually a sexually transmitted disease, is a risk factor for cervical cancer. Given the substantial disease and death associated with HPV and cervical cancer, development of a prophylactic HPV vaccine is a public health priority. We evaluated the cost-effectiveness of vaccinating adolescent girls for high-risk HPV infections relative to current practice. A vaccine with a 75% probability of immunity against high-risk HPV infection resulted in a life-expectancy gain of 2.8 days or 4.0 quality-adjusted life days at a cost of $246 relative to current practice (incremental cost effectiveness of $22,755/quality-adjusted life year [QALY]). If all 12-year-old girls currently living in the United States were vaccinated, >1,300 deaths from cervical cancer would be averted during their lifetimes. Vaccination of girls against high-risk HPV is relatively cost effective even when vaccine efficacy is low. If the vaccine efficacy rate is 35%, the cost effectiveness increases to $52,398/QALY. Although gains in life expectancy may be modest at the individual level, population benefits are substantial.

journal_name

Emerg Infect Dis

authors

Sanders GD,Taira AV

doi

10.3201/eid0901.020168

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

37-48

issue

1

eissn

1080-6040

issn

1080-6059

journal_volume

9

pub_type

杂志文章
  • Capnocytophaga canimorsus Capsular Serovar and Disease Severity, Helsinki Hospital District, Finland, 2000-2017.

    abstract::We assembled a collection of 73 Capnocytophaga canimorsus isolates obtained from blood cultures taken from patients treated at Helsinki University Hospital (Helsinki, Finland) during 2000-2017. We serotyped these isolates by PCR and Western blot and attempted to correlate pathogen serovar with patient characteristics....

    journal_title:Emerging infectious diseases

    pub_type: 历史文章,杂志文章

    doi:10.3201/eid2412.172060

    authors: Hess E,Renzi F,Karhunen P,Dol M,Lefèvre A,Antikainen J,Carlier E,Hästbacka J,Cornelis GR

    更新日期:2018-12-01 00:00:00

  • Outbreak of Middle East Respiratory Syndrome at Tertiary Care Hospital, Jeddah, Saudi Arabia, 2014.

    abstract::During March-May 2014, a Middle East respiratory syndrome (MERS) outbreak occurred in Jeddah, Saudi Arabia, that included many persons who worked or received medical treatment at King Fahd General Hospital. We investigated 78 persons who had laboratory-confirmed MERS during March 2-May 10 and documented contact at thi...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2205.151797

    authors: Hastings DL,Tokars JI,Abdel Aziz IZ,Alkhaldi KZ,Bensadek AT,Alraddadi BM,Jokhdar H,Jernigan JA,Garout MA,Tomczyk SM,Oboho IK,Geller AI,Arinaminpathy N,Swerdlow DL,Madani TA

    更新日期:2016-05-01 00:00:00

  • Disease Burden of Clostridium difficile Infections in Adults, Hong Kong, China, 2006-2014.

    abstract::Cross-sectional studies suggest an increasing trend in incidence and relatively low recurrence rates of Clostridium difficile infections in Asia than in Europe and North America. The temporal trend of C. difficile infection in Asia is not completely understood. We conducted a territory-wide population-based observatio...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2310.170797

    authors: Ho J,Dai RZW,Kwong TNY,Wang X,Zhang L,Ip M,Chan R,Hawkey PMK,Lam KLY,Wong MCS,Tse G,Chan MTV,Chan FKL,Yu J,Ng SC,Lee N,Wu JCY,Sung JJY,Wu WKK,Wong SH

    更新日期:2017-10-01 00:00:00

  • Osler and the infected letter.

    abstract::The spread of infectious agents through the mail has concerned public health officials for 5 centuries. The dissemination of anthrax spores in the US mail in 2001 was a recent example. In 1901, two medical journals reported outbreaks of smallpox presumably introduced by letters contaminated with variola viruses. The s...

    journal_title:Emerging infectious diseases

    pub_type: 传,历史文章,杂志文章

    doi:10.3201/eid1105.040616

    authors: Ambrose CT

    更新日期:2005-05-01 00:00:00

  • Diphtheria in the former Soviet Union: reemergence of a pandemic disease.

    abstract::The massive reemergence of diphtheria in the Newly Independent States of the former Soviet Union marked the first large-scale diphtheria epidemic in industrialized countries in 3 decades. Factors contributing to the epidemic included a large population of susceptible adults; decreased childhood immunization, which com...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章,评审

    doi:10.3201/eid0404.980404

    authors: Vitek CR,Wharton M

    更新日期:1998-10-01 00:00:00

  • Molecular Description of a Novel Orientia Species Causing Scrub Typhus in Chile.

    abstract::Scrub typhus is a potentially fatal rickettsiosis caused by Orientia species intracellular bacteria of the genus Orientia. Although considered to be restricted to the Asia Pacific region, scrub typhus has recently been discovered in southern Chile. We analyzed Orientia gene sequences of 16S rRNA (rrs) and 47-kDa (htrA...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2609.200918

    authors: Abarca K,Martínez-Valdebenito C,Angulo J,Jiang J,Farris CM,Richards AL,Acosta-Jamett G,Weitzel T

    更新日期:2020-09-01 00:00:00

  • Antimicrobial drugs and community-acquired Clostridium difficile-associated disease, UK.

    abstract::In a population-based case-control study of community acquired Clostridium difficile-associated disease (CDAD), we matched 1,233 cases to 12,330 controls. CDAD risk increased 3-fold with use of any antimicrobial agent and 6-fold with use of fluoroquinolones. Prior use of antimicrobial agents did not affect risk for CD...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1305.061124

    authors: Delaney JA,Dial S,Barkun A,Suissa S

    更新日期:2007-05-01 00:00:00

  • Polymerase chain reaction assay and bacterial meningitis surveillance in remote areas, Niger.

    abstract::To compensate for the lack of laboratories in remote areas, the national reference laboratory for meningitis in Niger used polymerase chain reaction (PCR) to enhance the surveillance of meningitis caused by Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae. PCR effectively documented the wid...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid0911.030462

    authors: Sidikou F,Djibo S,Taha MK,Alonso JM,Djibo A,Kairo KK,Chanteau S,Boisier P

    更新日期:2003-11-01 00:00:00

  • Foodborne outbreak and nonmotile Salmonella enterica variant, France.

    abstract::We report a food-related outbreak of salmonellosis in humans caused by a nonmotile variant of Salmonella enterica serotype Typhimurium in France in 2009. This nonmotile variant had been circulating in laying hens but was not considered as Typhimurium and consequently escaped European poultry flock regulations. ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1801.110450

    authors: Le Hello S,Brisabois A,Accou-Demartin M,Josse A,Marault M,Francart S,Da Silva NJ,Weill FX

    更新日期:2012-01-01 00:00:00

  • Cosavirus infection in persons with and without gastroenteritis, Brazil.

    abstract::To determine possible cosavirus association with clinical disease, we used real-time reverse transcription PCR to test children and HIV-positive adults in Brazil with and without gastroenteritis. Thirteen (3.6%) of 359 children with gastroenteritis tested positive, as did 69 (33.8%) of 204 controls. Low prevalence, fr...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1804.111415

    authors: Stöcker A,Souza BF,Ribeiro TC,Netto EM,Araujo LO,Corrêa JI,Almeida PS,de Mattos AP,Ribeiro Hda C Jr,Pedral-Sampaio DB,Drosten C,Drexler JF

    更新日期:2012-04-01 00:00:00

  • Radical Change in Zoonotic Abilities of Atypical BSE Prion Strains as Evidenced by Crossing of Sheep Species Barrier in Transgenic Mice.

    abstract::Classical bovine spongiform encephalopathy (BSE) is the only zoonotic prion disease described to date. Although the zoonotic potential of atypical BSE prions have been partially studied, an extensive analysis is still needed. We conducted a systematic study by inoculating atypical BSE isolates from different countries...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2606.181790

    authors: Marín-Moreno A,Huor A,Espinosa JC,Douet JY,Aguilar-Calvo P,Aron N,Píquer J,Lugan S,Lorenzo P,Tillier C,Cassard H,Andreoletti O,Torres JM

    更新日期:2020-06-01 00:00:00

  • Global illness and deaths caused by rotavirus disease in children.

    abstract::To estimate the global illness and deaths caused by rotavirus disease, we reviewed studies published from 1986 to 2000 on deaths caused by diarrhea and on rotavirus infections in children. We assessed rotavirus-associated illness in three clinical settings (mild cases requiring home care alone, moderate cases requirin...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章,meta分析

    doi:10.3201/eid0905.020562

    authors: Parashar UD,Hummelman EG,Bresee JS,Miller MA,Glass RI

    更新日期:2003-05-01 00:00:00

  • Evidence-based tool for triggering school closures during influenza outbreaks, Japan.

    abstract::Guidelines available to school administrators to support school closure decisions during influenza outbreaks are usually not evidence-based. Using empirical data on absentee rates of elementary school students in Japan, we developed a simple and practical algorithm for determining the optimal timing of school closures...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:

    authors: Sasaki A,Hoen AG,Ozonoff A,Suzuki H,Tanabe N,Seki N,Saito R,Brownstein JS

    更新日期:2009-11-01 00:00:00

  • Human metapneumovirus detection in patients with severe acute respiratory syndrome.

    abstract::We used a combination approach of conventional virus isolation and molecular techniques to detect human metapneumovirus (HMPV) in patients with severe acute respiratory syndrome (SARS). Of the 48 study patients, 25 (52.1%) were infected with HMPV; 6 of these 25 patients were also infected with coronavirus, and another...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid0909.030304

    authors: Chan PK,Tam JS,Lam CW,Chan E,Wu A,Li CK,Buckley TA,Ng KC,Joynt GM,Cheng FW,To KF,Lee N,Hui DS,Cheung JL,Chu I,Liu E,Chung SS,Sung JJ

    更新日期:2003-09-01 00:00:00

  • Bed bug infestations in an urban environment.

    abstract::Until recently, bed bugs have been considered uncommon in the industrialized world. This study determined the extent of reemerging bed bug infestations in homeless shelters and other locations in Toronto, Canada. Toronto Public Health documented complaints of bed bug infestations from 46 locations in 2003, most common...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1104.041126

    authors: Hwang SW,Svoboda TJ,De Jong IJ,Kabasele KJ,Gogosis E

    更新日期:2005-04-01 00:00:00

  • Rift Valley Fever Outbreak, Mayotte, France, 2018-2019.

    abstract::From November 2018 through July 2019, an outbreak of Rift Valley fever in humans occurred in Mayotte, France; 142 cases were confirmed. Exposure to animals or their biological fluid was reported by 73% of patients. Health authorities have been implementing control measures, including veterinary surveys, vector control...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2604.191147

    authors: Youssouf H,Subiros M,Dennetiere G,Collet L,Dommergues L,Pauvert A,Rabarison P,Vauloup-Fellous C,Le Godais G,Jaffar-Bandjee MC,Jean M,Paty MC,Noel H,Oliver S,Filleul L,Larsen C

    更新日期:2020-04-01 00:00:00

  • Mathematical Modeling of Programmatic Requirements for Yaws Eradication.

    abstract::Yaws is targeted for eradication by 2020. The mainstay of the eradication strategy is mass treatment followed by case finding. Modeling has been used to inform programmatic requirements for other neglected tropical diseases and could provide insights into yaws eradication. We developed a model of yaws transmission var...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2301.160487

    authors: Marks M,Mitjà O,Fitzpatrick C,Asiedu K,Solomon AW,Mabey DC,Funk S

    更新日期:2017-01-01 00:00:00

  • Human parechovirus 3 and neonatal infections.

    abstract::A third serotype of human parechovirus (HPeV) has been recently isolated from stool specimens of a young Japanese child with transient paralysis. We report 3 additional cases of neonatal sepsis caused by HPeV-3 in the fall of 2001 in Canadian infants 7-27 days old. All children were hospitalized with high fever, eryth...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1101.040606

    authors: Boivin G,Abed Y,Boucher FD

    更新日期:2005-01-01 00:00:00

  • Escherichia coli O157 infection and secondary spread, Scotland, 1999-2008.

    abstract::To determine the proportion of Escherichia coli O157 cases in Scotland attributable to secondary spread, we analyzed data obtained through entire-population enhanced surveillance. We identified 11% of cases as secondary. Secondary cases in single households were younger than secondary cases in outbreaks affecting >1 h...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1703.100167

    authors: Locking ME,Pollock KG,Allison LJ,Rae L,Hanson MF,Cowden JM

    更新日期:2011-03-01 00:00:00

  • Rift Valley fever, Sudan, 2007 and 2010.

    abstract::To elucidate whether Rift Valley fever virus (RVFV) diversity in Sudan resulted from multiple introductions or from acquired changes over time from 1 introduction event, we generated complete genome sequences from RVFV strains detected during the 2007 and 2010 outbreaks. Phylogenetic analyses of small, medium, and lar...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1902.120834

    authors: Aradaib IE,Erickson BR,Elageb RM,Khristova ML,Carroll SA,Elkhidir IM,Karsany ME,Karrar AE,Elbashir MI,Nichol ST

    更新日期:2013-02-01 00:00:00

  • Role of Waddlia chondrophila placental infection in miscarriage.

    abstract::Waddlia chondrophila is an intracellular bacterium suspected to cause human and bovine abortion. We confirmed an association between antibodies against W. chondrophila and human miscarriage and identified this organism in placenta or genital tract of women who had had miscarriages. These results suggest a possible rol...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2003.131019

    authors: Baud D,Goy G,Osterheld MC,Croxatto A,Borel N,Vial Y,Pospischil A,Greub G

    更新日期:2014-03-01 00:00:00

  • Ecoepidemiology of cutaneous leishmaniasis outbreak, Israel.

    abstract::A total of 161 cases of cutaneous leishmaniasis caused by Leishmania tropica occurred in the Jerusalem district during 2004-2005; 127 (79%) cases were in a town just outside Jerusalem. Environmental models suggest that in the context of global warming, this outbreak has the potential to extend into Jerusalem. ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1409.071100

    authors: Singer SR,Abramson N,Shoob H,Zaken O,Zentner G,Stein-Zamir C

    更新日期:2008-09-01 00:00:00

  • Evidence Supporting Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 While Presymptomatic or Asymptomatic.

    abstract::Recent epidemiologic, virologic, and modeling reports support the possibility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission from persons who are presymptomatic (SARS-CoV-2 detected before symptom onset) or asymptomatic (SARS-CoV-2 detected but symptoms never develop). SARS-CoV-2 transmis...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2607.201595

    authors: Furukawa NW,Brooks JT,Sobel J

    更新日期:2020-07-01 00:00:00

  • Rapid emergence of ciprofloxacin-resistant enterobacteriaceae containing multiple gentamicin resistance-associated integrons in a Dutch hospital.

    abstract::In a hematology unit in the Netherlands, the incidence of ciprofloxacin-resistant Enterobacter cloacae and Escherichia coli increased from from 1996 to 1999. Clonal spread of single genotypes of both ciprofloxacin-resistant E. coli and Enterobacter cloacae from patient to patient was documented by pulsed-field gel ele...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid0705.017515

    authors: van Belkum A,Goessens W,van der Schee C,Lemmens-den Toom N,Vos MC,Cornelissen J,Lugtenburg E,de Marie S,Verbrugh H,Löwenberg B,Endtz H

    更新日期:2001-09-01 00:00:00

  • Distribution of eosinophilic meningitis cases attributable to Angiostrongylus cantonensis, Hawaii.

    abstract::During November 2004-January 2005, 5 cases of eosinophilic meningitis (EM) attributable to Angiostrongylus cantonensis infection were reported in Hawaii. To determine if this temporal clustering reflected an increased incidence, we ascertained EM and A. cantonensis cases by systematic review of statewide laboratory an...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1311.070367

    authors: Hochberg NS,Park SY,Blackburn BG,Sejvar JJ,Gaynor K,Chung H,Leniek K,Herwaldt BL,Effler PV

    更新日期:2007-11-01 00:00:00

  • Serologic analysis of returned travelers with fever, Sweden.

    abstract::We studied 1,432 febrile travelers from Sweden who had returned from malaria-endemic areas during March 2005-March 2008. In 383 patients, paired serum samples were blindly analyzed for influenza and 7 other agents. For 21% of 115 patients with fever of unknown origin, serologic analysis showed that influenza was the m...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章,多中心研究

    doi:10.3201/eid1511.091157

    authors: Askling HH,Lesko B,Vene S,Berndtson A,Björkman P,Bläckberg J,Bronner U,Follin P,Hellgren U,Palmerus M,Ekdahl K,Tegnell A,Struwe J

    更新日期:2009-11-01 00:00:00

  • Preventing Sexual Transmission of Zika Virus Infection during Pregnancy, Puerto Rico, USA, 20161.

    abstract::We examined condom use throughout pregnancy during the Zika outbreak in Puerto Rico during 2016. Overall, <25% of women reported consistent condom use during pregnancy. However, healthcare provider counseling was associated with a 3-fold increase in consistent use, reinforcing the value of provider counseling in Zika ...

    journal_title:Emerging infectious diseases

    pub_type: 历史文章,杂志文章

    doi:10.3201/eid2511.190915

    authors: Salvesen von Essen B,Kortsmit K,Warner L,D'Angelo DV,Shulman HB,Virella WH,Taraporewalla A,Harrison L,Ellington S,Shapiro-Mendoza C,Barfield W,Smith RA,Jamieson DJ,Cox S,Pazol K,Díaz PG,Herrera BR,Bernal MV,Puerto Ric

    更新日期:2019-11-01 00:00:00

  • Mutations in influenza A virus (H5N1) and possible limited spread, Turkey, 2006.

    abstract::We report mutations in influenza A virus (H5N1) strains associated with 2 outbreaks in Turkey. Four novel amino acid changes (Q447L, N556K, and R46K in RNA polymerase and S133A in hemagglutinin) were detected in virus isolates from 2 siblings who died. ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1403.061237

    authors: Altiok E,Taylan F,Yenen OS,Demirkeser G,Bozaci M,Onel D,Akcadag B,Iyisan AS,Ciblak M,Bozkaya E,Yuksel S,Badur S

    更新日期:2008-03-01 00:00:00

  • Severe Acute Respiratory Syndrome Coronavirus 2 among Asymptomatic Workers Screened for Work Resumption, China.

    abstract::After the outbreak in Wuhan, China, we assessed 29,299 workers screened for severe acute respiratory syndrome coronavirus 2 by reverse transcription PCR. We noted 18 (0.061%) cases of asymptomatic infection; 13 turned negative within 8.0 days, and 41 close contacts tested negative. Among 6 contacts who had serologic t...

    journal_title:Emerging infectious diseases

    pub_type: 信件

    doi:10.3201/eid2609.201848

    authors: Han X,Wei X,Alwalid O,Cao Y,Li Y,Wang L,Shi H

    更新日期:2020-09-01 00:00:00

  • Loiasis in US Traveler Returning from Bioko Island, Equatorial Guinea, 2016.

    abstract::The filarial parasite Loa loa overlaps geographically with Onchocera volvulus and Wuchereria bancrofti filariae in central Africa. Accurate information regarding this overlap is critical to elimination programs targeting O. volvulus and W. bancrofti. We describe a case of loiasis in a traveler returning from Bioko Isl...

    journal_title:Emerging infectious diseases

    pub_type: 信件

    doi:10.3201/eid2301.161427

    authors: Priest DH,Nutman TB

    更新日期:2017-01-01 00:00:00