Abstract:
:Cross-sectional studies suggest an increasing trend in incidence and relatively low recurrence rates of Clostridium difficile infections in Asia than in Europe and North America. The temporal trend of C. difficile infection in Asia is not completely understood. We conducted a territory-wide population-based observational study to investigate the burden and clinical outcomes in Hong Kong, China, over a 9-year period. A total of 15,753 cases were identified, including 14,402 (91.4%) healthcare-associated cases and 817 (5.1%) community-associated cases. After adjustment for diagnostic test, we found that incidence increased from 15.41 cases/100,000 persons in 2006 to 36.31 cases/100,000 persons in 2014, an annual increase of 26%. This increase was associated with elderly patients, for whom incidence increased 3-fold over the period. Recurrence at 60 days increased from 5.7% in 2006 to 9.1% in 2014 (p<0.001). Our data suggest the need for further surveillance, especially in Asia, which contains ≈60% of the world's population.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Ho J,Dai RZW,Kwong TNY,Wang X,Zhang L,Ip M,Chan R,Hawkey PMK,Lam KLY,Wong MCS,Tse G,Chan MTV,Chan FKL,Yu J,Ng SC,Lee N,Wu JCY,Sung JJY,Wu WKK,Wong SHdoi
10.3201/eid2310.170797subject
Has Abstractpub_date
2017-10-01 00:00:00pages
1671-1679issue
10eissn
1080-6040issn
1080-6059journal_volume
23pub_type
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