Molecular Description of a Novel Orientia Species Causing Scrub Typhus in Chile.

Abstract:

:Scrub typhus is a potentially fatal rickettsiosis caused by Orientia species intracellular bacteria of the genus Orientia. Although considered to be restricted to the Asia Pacific region, scrub typhus has recently been discovered in southern Chile. We analyzed Orientia gene sequences of 16S rRNA (rrs) and 47-kDa (htrA) from 18 scrub typhus patients from Chile. Sequences were ≥99.7% identical among the samples for both amplified genes. Their diversity was 3.1%-3.5% for rrs and 11.2%-11.8% for htrA compared with O. tsusugamushi and 3.0% for rrs and 14.8% for htrA compared with Candidatus Orientia chuto. Phylogenetic analyses of both genes grouped the specimens from Chile in a different clade from other Orientia species. Our results indicate that Orientia isolates from Chile constitute a novel species, which, until they are cultivated and fully characterized, we propose to designate as Candidatus Orientia chiloensis, after the Chiloé Archipelago where the pathogen was identified.

journal_name

Emerg Infect Dis

authors

Abarca K,Martínez-Valdebenito C,Angulo J,Jiang J,Farris CM,Richards AL,Acosta-Jamett G,Weitzel T

doi

10.3201/eid2609.200918

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

2148-2156

issue

9

eissn

1080-6040

issn

1080-6059

journal_volume

26

pub_type

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