Rift Valley fever, Sudan, 2007 and 2010.

Abstract:

:To elucidate whether Rift Valley fever virus (RVFV) diversity in Sudan resulted from multiple introductions or from acquired changes over time from 1 introduction event, we generated complete genome sequences from RVFV strains detected during the 2007 and 2010 outbreaks. Phylogenetic analyses of small, medium, and large RNA segment sequences indicated several genetic RVFV variants were circulating in Sudan, which all grouped into Kenya-1 or Kenya-2 sublineages from the 2006-2008 eastern Africa epizootic. Bayesian analysis of sequence differences estimated that diversity among the 2007 and 2010 Sudan RVFV variants shared a most recent common ancestor circa 1996. The data suggest multiple introductions of RVFV into Sudan as part of sweeping epizootics from eastern Africa. The sequences indicate recent movement of RVFV and support the need for surveillance to recognize when and where RVFV circulates between epidemics, which can make data from prediction tools easier to interpret and preventive measures easier to direct toward high-risk areas.

journal_name

Emerg Infect Dis

authors

Aradaib IE,Erickson BR,Elageb RM,Khristova ML,Carroll SA,Elkhidir IM,Karsany ME,Karrar AE,Elbashir MI,Nichol ST

doi

10.3201/eid1902.120834

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

246-53

issue

2

eissn

1080-6040

issn

1080-6059

journal_volume

19

pub_type

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