Abstract:
:To elucidate whether Rift Valley fever virus (RVFV) diversity in Sudan resulted from multiple introductions or from acquired changes over time from 1 introduction event, we generated complete genome sequences from RVFV strains detected during the 2007 and 2010 outbreaks. Phylogenetic analyses of small, medium, and large RNA segment sequences indicated several genetic RVFV variants were circulating in Sudan, which all grouped into Kenya-1 or Kenya-2 sublineages from the 2006-2008 eastern Africa epizootic. Bayesian analysis of sequence differences estimated that diversity among the 2007 and 2010 Sudan RVFV variants shared a most recent common ancestor circa 1996. The data suggest multiple introductions of RVFV into Sudan as part of sweeping epizootics from eastern Africa. The sequences indicate recent movement of RVFV and support the need for surveillance to recognize when and where RVFV circulates between epidemics, which can make data from prediction tools easier to interpret and preventive measures easier to direct toward high-risk areas.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Aradaib IE,Erickson BR,Elageb RM,Khristova ML,Carroll SA,Elkhidir IM,Karsany ME,Karrar AE,Elbashir MI,Nichol STdoi
10.3201/eid1902.120834subject
Has Abstractpub_date
2013-02-01 00:00:00pages
246-53issue
2eissn
1080-6040issn
1080-6059journal_volume
19pub_type
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