Abstract:
:To characterize genetic variation of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) transmitted in the Beijing area during the epidemic outbreak of 2003, we sequenced 29 full-length S genes of SARS-CoV from 20 hospitalized SARS patients on our unit, the Beijing 302 Hospital. Viral RNA templates for the S-gene amplification were directly extracted from raw clinical samples, including plasma, throat swab, sputum, and stool, during the course of the epidemic in the Beijing area. We used a TA-cloning assay with direct analysis of nested reverse transcription-polymerase chain reaction products in sequence. One hundred thirteen sequence variations with nine recurrent variant sites were identified in analyzed S-gene sequences compared with the BJ01 strain of SARS-CoV. Among them, eight variant sites were, we think, the first documented. Our findings demonstrate the coexistence of S-gene sequences with and without substitutions (compared to BJ01) in samples analyzed from some patients.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Xu D,Zhang Z,Chu F,Li Y,Jin L,Zhang L,Gao GF,Wang FSdoi
10.3201/eid1005.030875subject
Has Abstractpub_date
2004-05-01 00:00:00pages
789-94issue
5eissn
1080-6040issn
1080-6059journal_volume
10pub_type
杂志文章abstract::Outbreaks of West Nile (WN) virus occurred in the New York metropolitan area in 1999 and 2000. Nineteen patients diagnosed with WN infection were hospitalized in New York and New Jersey in 2000 and were included in this review. Eleven patients had encephalitis or meningoencephalitis, and eight had meningitis alone. Ag...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid0704.010409
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journal_title:Emerging infectious diseases
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doi:10.3201/eid1901.111527
更新日期:2013-01-01 00:00:00
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journal_title:Emerging infectious diseases
pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
abstract::Global surveillance for a novel rhinovirus genotype indicated its association with community outbreaks and pediatric respiratory disease in Africa, Asia, Australia, Europe, and North America. Molecular dating indicates that these viruses have been circulating for at least 250 years. ...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Emerging infectious diseases
pub_type: 历史文章,杂志文章
doi:10.3201/eid2313.170550
更新日期:2017-12-01 00:00:00
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pub_type: 杂志文章
doi:10.3201/eid0704.010424
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pub_type: 杂志文章
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更新日期:2020-08-01 00:00:00
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journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1708.100769
更新日期:2011-08-01 00:00:00
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journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1012.040459
更新日期:2004-12-01 00:00:00
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journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1707.101959
更新日期:2011-07-01 00:00:00
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journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid2302.161432
更新日期:2017-02-01 00:00:00
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pub_type: 历史文章,杂志文章
doi:10.3201/eid2305.160768
更新日期:2017-05-01 00:00:00
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pub_type: 杂志文章
doi:10.3201/eid1407.080096
更新日期:2008-07-01 00:00:00
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journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1601.090994
更新日期:2010-01-01 00:00:00
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journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid2510.181610
更新日期:2019-10-01 00:00:00
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journal_title:Emerging infectious diseases
pub_type: 信件
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更新日期:2019-11-01 00:00:00
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pub_type: 杂志文章,评审
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doi:10.3201/eid1411.080719
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journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1702.100442
更新日期:2011-02-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
doi:10.3201/eid1704.101353
更新日期:2011-04-01 00:00:00
abstract::Previous studies have shown a high prevalence of toxoplasmosis and the frequent occurrence of ocular disease in Brazil. To identify the genotypes of parasite strains associated with ocular disease, we compared 25 clinical and animal isolates of Toxoplasma gondii from Brazil to previously characterized clonal lineages ...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
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更新日期:2006-06-01 00:00:00
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pub_type: 历史文章,杂志文章
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更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章
doi:10.3201/eid1703.100851
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journal_title:Emerging infectious diseases
pub_type: 杂志文章
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更新日期:2009-11-01 00:00:00
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journal_title:Emerging infectious diseases
pub_type: 信件
doi:10.3201/eid2407.171754
更新日期:2018-07-01 00:00:00