Abstract:
:Serologic studies for swine influenza viruses (SIVs) in humans with occupational exposure to swine have been reported from the Americas but not from Europe. We compared levels of neutralizing antibodies against 3 influenza viruses--pandemic (H1N1) 2009, an avian-like enzootic subtype H1N1 SIV, and a 2007-08 seasonal subtype H1N1--in 211 persons with swine contact and 224 matched controls in Luxembourg. Persons whose profession involved contact with swine had more neutralizing antibodies against SIV and pandemic (H1N1) 2009 virus than did the controls. Controls also had antibodies against these viruses although exposure to them was unlikely. Antibodies against SIV and pandemic (H1N1) 2009 virus correlated with each other but not with seasonal subtype H1N1 virus. Sequential exposure to variants of seasonal influenza (H1N1) viruses may have increased chances for serologic cross-reactivity with antigenically distinct viruses. Further studies are needed to determine the extent to which serologic responses correlate with infection.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Gerloff NA,Kremer JR,Charpentier E,Sausy A,Olinger CM,Weicherding P,Schuh J,Van Reeth K,Muller CPdoi
10.3201/eid1703.100851subject
Has Abstractpub_date
2011-03-01 00:00:00pages
403-11issue
3eissn
1080-6040issn
1080-6059journal_volume
17pub_type
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