Abstract:
:All hepatitis E virus (HEV) variants reported to infect humans belong to the species Orthohepevirus A (HEV-A). The zoonotic potential of the species Orthohepevirus C (HEV-C), which circulates in rats and is highly divergent from HEV-A, is unknown. We report a liver transplant recipient with hepatitis caused by HEV-C infection. We detected HEV-C RNA in multiple clinical samples and HEV-C antigen in the liver. The complete genome of the HEV-C isolate had 93.7% nt similarity to an HEV-C strain from Vietnam. The patient had preexisting HEV antibodies, which were not protective against HEV-C infection. Ribavirin was an effective treatment, resulting in resolution of hepatitis and clearance of HEV-C viremia. Testing for this zoonotic virus should be performed for immunocompromised and immunocompetent patients with unexplained hepatitis because routine hepatitis E diagnostic tests may miss HEV-C infection. HEV-C is also a potential threat to the blood product supply.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Sridhar S,Yip CCY,Wu S,Cai J,Zhang AJ,Leung KH,Chung TWH,Chan JFW,Chan WM,Teng JLL,Au-Yeung RKH,Cheng VCC,Chen H,Lau SKP,Woo PCY,Xia NS,Lo CM,Yuen KYdoi
10.3201/eid2412.180937subject
Has Abstractpub_date
2018-12-01 00:00:00pages
2241-2250issue
12eissn
1080-6040issn
1080-6059journal_volume
24pub_type
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