Antimicrobial drug resistance, regulation, and research.

Abstract:

:Innovative regulatory and legislative measures to stimulate and facilitate the development of new antimicrobial drugs are needed. We discuss research approaches that can aid regulatory decision making on the treatment of resistant infections and minimization of resistance selection. We also outline current and future measures that regulatory agencies may employ to help control resistance and promote drug development. Pharmacokinetic/pharmacodynamic research models offer promising approaches to define the determinants of resistance selection and drug doses that optimize efficacy and reduce resistance selection. Internationally, variations exist in how regulators use drug scheduling, subsidy restrictions, central directives, educational guidelines, amendments to prescribing information, and indication review. Recent consultations and collaborations between regulators, academics, and industry are welcome. Efforts to coordinate regulatory measures would benefit from greater levels of international dialogue.

journal_name

Emerg Infect Dis

authors

Metlay JP,Powers JH,Dudley MN,Christiansen K,Finch RG

doi

10.3201/eid1202.050078

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

183-90

issue

2

eissn

1080-6040

issn

1080-6059

journal_volume

12

pub_type

杂志文章
  • Detection of SARS-associated coronavirus in throat wash and saliva in early diagnosis.

    abstract::The severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is thought to be transmitted primarily through dispersal of droplets, but little is known about the load of SARS-CoV in oral droplets. We examined oral specimens, including throat wash and saliva, and found large amounts of SARS-CoV RNA in both th...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1007.031113

    authors: Wang WK,Chen SY,Liu IJ,Chen YC,Chen HL,Yang CF,Chen PJ,Yeh SH,Kao CL,Huang LM,Hsueh PR,Wang JT,Sheng WH,Fang CT,Hung CC,Hsieh SM,Su CP,Chiang WC,Yang JY,Lin JH,Hsieh SC,Hu HP,Chiang YP,Wang JT,Yang PC,Ch

    更新日期:2004-07-01 00:00:00

  • Diphtheria in the former Soviet Union: reemergence of a pandemic disease.

    abstract::The massive reemergence of diphtheria in the Newly Independent States of the former Soviet Union marked the first large-scale diphtheria epidemic in industrialized countries in 3 decades. Factors contributing to the epidemic included a large population of susceptible adults; decreased childhood immunization, which com...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章,评审

    doi:10.3201/eid0404.980404

    authors: Vitek CR,Wharton M

    更新日期:1998-10-01 00:00:00

  • Preventing Sexual Transmission of Zika Virus Infection during Pregnancy, Puerto Rico, USA, 20161.

    abstract::We examined condom use throughout pregnancy during the Zika outbreak in Puerto Rico during 2016. Overall, <25% of women reported consistent condom use during pregnancy. However, healthcare provider counseling was associated with a 3-fold increase in consistent use, reinforcing the value of provider counseling in Zika ...

    journal_title:Emerging infectious diseases

    pub_type: 历史文章,杂志文章

    doi:10.3201/eid2511.190915

    authors: Salvesen von Essen B,Kortsmit K,Warner L,D'Angelo DV,Shulman HB,Virella WH,Taraporewalla A,Harrison L,Ellington S,Shapiro-Mendoza C,Barfield W,Smith RA,Jamieson DJ,Cox S,Pazol K,Díaz PG,Herrera BR,Bernal MV,Puerto Ric

    更新日期:2019-11-01 00:00:00

  • Cross-Neutralization between Human and African Bat Mumps Viruses.

    abstract::Recently, a new paramyxovirus closely related to human mumps virus (MuV) was detected in bats. We generated recombinant MuVs carrying either or both of the fusion and hemagglutinin-neuraminidase bat virus glycoproteins. These viruses showed replication kinetics similar to human MuV in cultured cells and were neutraliz...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2204.151116

    authors: Katoh H,Kubota T,Ihara T,Maeda K,Takeda M,Kidokoro M

    更新日期:2016-04-01 00:00:00

  • Travel Health Alert Notices and Haiti cholera outbreak, Florida, USA, 2011.

    abstract::To enhance the timeliness of medical evaluation for cholera-like illness during the 2011 cholera outbreak in Hispaniola, printed Travel Health Alert Notices (T-HANs) were distributed to travelers from Haiti to the United States. Evaluation of the T-HANs’ influence on travelers’ health care–seeking behavior suggested T...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1711.110721

    authors: Selent MU,McWhorter A,De Rochars VM,Myers R,Hunter DW,Brown CM,Cohen NJ,Molinari NA,Warwar K,Robbins D,Heiman KE,Newton AE,Schmitz A,Oraze MJ,Marano N

    更新日期:2011-11-01 00:00:00

  • Environmental Burkholderia cepacia complex isolates in human infections.

    abstract::Members of the Burkholderia cepacia complex (Bcc), found in many environments, are associated with clinical infections. Examining diverse species and strains from different environments with multilocus sequence typing, we identified > 20% of 381 clinical isolates as indistinguishable from those in the environment. Thi...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1303.060403

    authors: Baldwin A,Mahenthiralingam E,Drevinek P,Vandamme P,Govan JR,Waine DJ,LiPuma JJ,Chiarini L,Dalmastri C,Henry DA,Speert DP,Honeybourne D,Maiden MC,Dowson CG

    更新日期:2007-03-01 00:00:00

  • Geographic and temporal trends in influenzalike illness, Japan, 1992-1999.

    abstract::From 1992 to 1999, we analyzed >2.5 million cases of influenzalike illness (ILI). Nationwide influenza epidemics generally lasted 3-4 months in winter. Kriging analysis, which illustrates geographic movement, showed that the starting areas of peak ILI activity were mostly found in western Japan. Two spreading patterns...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1010.040147

    authors: Sakai T,Suzuki H,Sasaki A,Saito R,Tanabe N,Taniguchi K

    更新日期:2004-10-01 00:00:00

  • Nontuberculous Mycobacteria, Botswana, 2011-2014.

    abstract::We documented a 6-fold increase in the frequency of nontuberculous mycobacteria isolated from clinical samples in Botswana during 2011-2014. Because antituberculosis treatment is often initiated only on the basis of acid-fast bacilli smear-positive microscopy results, some patients with nontuberculous mycobacterial in...

    journal_title:Emerging infectious diseases

    pub_type: 历史文章,杂志文章

    doi:10.3201/eid2507.181440

    authors: Mbeha B,Mine M,Motswaledi MS,Dewar J

    更新日期:2019-07-01 00:00:00

  • Lyssaviruses in Insectivorous Bats, South Africa, 2003-2018.

    abstract::We detected 3 lyssaviruses in insectivorous bats sampled in South Africa during 2003-2018. We used phylogenetic analysis to identify Duvenhage lyssavirus and a potentially new lyssavirus, provisionally named Matlo bat lyssavirus, that is related to West Caucasian bat virus. These new detections highlight that much abo...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2612.203592

    authors: Coertse J,Grobler CS,Sabeta CT,Seamark ECJ,Kearney T,Paweska JT,Markotter W

    更新日期:2020-12-01 00:00:00

  • Genetic divergence of Toxoplasma gondii strains associated with ocular toxoplasmosis, Brazil.

    abstract::Previous studies have shown a high prevalence of toxoplasmosis and the frequent occurrence of ocular disease in Brazil. To identify the genotypes of parasite strains associated with ocular disease, we compared 25 clinical and animal isolates of Toxoplasma gondii from Brazil to previously characterized clonal lineages ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1206.060025

    authors: Khan A,Jordan C,Muccioli C,Vallochi AL,Rizzo LV,Belfort R Jr,Vitor RW,Silveira C,Sibley LD

    更新日期:2006-06-01 00:00:00

  • Infectious causes of chronic inflammatory diseases and cancer.

    abstract::Powerful diagnostic technology, plus the realization that organisms of otherwise unimpressive virulence can produce slowly progressive chronic disease with a wide spectrum of clinical manifestations and disease outcomes, has resulted in the discovery of new infectious agents and new concepts of infectious diseases. Th...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid0403.980339

    authors: Cassell GH

    更新日期:1998-07-01 00:00:00

  • Epidemiologic features of four successive annual outbreaks of bubonic plague in Mahajanga, Madagascar.

    abstract::From 1995 to 1998, outbreaks of bubonic plague occurred annually in the coastal city of Mahajanga, Madagascar. A total of 1,702 clinically suspected cases of bubonic plague were reported, including 515 laboratory confirmed by Yersinia pestis isolation (297), enzyme-linked immunosorbent assay, or both. Incidence was hi...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid0803.010250

    authors: Boisier P,Rahalison L,Rasolomaharo M,Ratsitorahina M,Mahafaly M,Razafimahefa M,Duplantier JM,Ratsifasoamanana L,Chanteau S

    更新日期:2002-03-01 00:00:00

  • Phenotypic similarity of transmissible mink encephalopathy in cattle and L-type bovine spongiform encephalopathy in a mouse model.

    abstract::Transmissible mink encepholapathy (TME) is a foodborne transmissible spongiform encephalopathy (TSE) of ranch-raised mink; infection with a ruminant TSE has been proposed as the cause, but the precise origin of TME is unknown. To compare the phenotypes of each TSE, bovine-passaged TME isolate and 3 distinct natural bo...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1312.070635

    authors: Baron T,Bencsik A,Biacabe AG,Morignat E,Bessen RA

    更新日期:2007-12-01 00:00:00

  • Information-Accessing Behavior during Zika Virus Outbreak, United States, 2016.

    abstract::We used latent class analysis to examine Zika virus-related information-accessing behavior of US residents during the 2016 international outbreak. We characterized 3 classes of information-accessing behavior patterns: universalists, media seekers, and passive recipients. Understanding these patterns is crucial to plan...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2609.191519

    authors: Piltch-Loeb R,Abramson D

    更新日期:2020-09-01 00:00:00

  • Mycobacterium bovis Infection of Red Fox, France.

    abstract::Mycobacterium bovis infection in wild red foxes was found in southern France, where livestock and other wildlife species are infected. Foxes frequently interact with cattle but have been underestimated as a reservoir of M. bovis. Our results suggest a possible role of the red fox in the epidemiology of bovine tubercul...

    journal_title:Emerging infectious diseases

    pub_type: 信件

    doi:10.3201/eid2406.180094

    authors: Michelet L,De Cruz K,Hénault S,Tambosco J,Richomme C,Réveillaud É,Gares H,Moyen JL,Boschiroli ML

    更新日期:2018-06-01 00:00:00

  • Advanced age a risk factor for illness temporally associated with yellow fever vaccination.

    abstract::In 1998, the Centers for Disease Control and Prevention was notified of severe illnesses and one death, temporally associated with yellow fever (YF) vaccination, in two elderly U.S. residents. Because the cases were unusual and adverse events following YF vaccination had not been studied, we estimated age-related repo...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid0706.010605

    authors: Martin M,Weld LH,Tsai TF,Mootrey GT,Chen RT,Niu M,Cetron MS,GeoSentinel Yellow Fever Working Group.

    更新日期:2001-11-01 00:00:00

  • Broiler chickens as source of human fluoroquinolone-resistant Escherichia coli, Iceland.

    abstract::To investigate feed as a source for fluoroquinolone-resistant Escherichia coli in broiler chickens, we compared antimicrobial drug-resistant E. coli from broiler feed and broilers with ciprofloxacin-resistant human clinical isolates by using pulsed-field gel electrophoresis. Feed was implicated as a source for ciprofl...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1601.090243

    authors: Thorsteinsdottir TR,Haraldsson G,Fridriksdottir V,Kristinsson KG,Gunnarsson E

    更新日期:2010-01-01 00:00:00

  • MERS coronaviruses in dromedary camels, Egypt.

    abstract::We identified the near-full-genome sequence (29,908 nt, >99%) of Middle East respiratory syndrome coronavirus (MERS-CoV) from a nasal swab specimen from a dromedary camel in Egypt. We found that viruses genetically very similar to human MERS-CoV are infecting dromedaries beyond the Arabian Peninsula, where human MERS-...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2006.140299

    authors: Chu DK,Poon LL,Gomaa MM,Shehata MM,Perera RA,Abu Zeid D,El Rifay AS,Siu LY,Guan Y,Webby RJ,Ali MA,Peiris M,Kayali G

    更新日期:2014-06-01 00:00:00

  • Melioidosis, phnom penh, Cambodia.

    abstract::We describe 58 adult patients with melioidosis in Cambodia (2007-2010). Diabetes was the main risk factor (59%); 67% of infections occurred during the rainy season. Bloodstream infection was present in 67% of patients, which represents 12% of all bloodstream infections. The case-fatality rate was 52% and associated wi...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1707.101069

    authors: Vlieghe E,Kruy L,De Smet B,Kham C,Veng CH,Phe T,Koole O,Thai S,Lynen L,Jacobs J

    更新日期:2011-07-01 00:00:00

  • Histologic features and immunodetection of African tick-bite fever eschar.

    abstract::African tick-bite fever (ATBF) is a rickettsiosis caused by Rickettsia africae. We describe histologic features and immunodetection of R. africae in cutaneous inoculation eschars from 8 patients with ATBF, which was diagnosed by culture or association of positive PCR detection and positive serologic results. We used q...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1209.051540

    authors: Lepidi H,Fournier PE,Raoult D

    更新日期:2006-09-01 00:00:00

  • Rickettsia prowazekii and real-time polymerase chain reaction.

    abstract::Rickettsia prowazekii is the causative agent of epidemic typhus and a potential bioterrorism agent. Sensitive and specific rapid assays are needed to complement existing methods of detecting this organism. We developed a real-time quantitative polymerase chain reaction assay by using a species-specific probe targeting...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1203.050888

    authors: Svraka S,Rolain JM,Bechah Y,Gatabazi J,Raoult D

    更新日期:2006-03-01 00:00:00

  • Indirect Virus Transmission in Cluster of COVID-19 Cases, Wenzhou, China, 2020.

    abstract::To determine possible modes of virus transmission, we investigated a cluster of coronavirus disease cases associated with a shopping mall in Wenzhou, China. Data indicated that indirect transmission of the causative virus occurred, perhaps resulting from virus contamination of common objects, virus aerosolization in a...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2606.200412

    authors: Cai J,Sun W,Huang J,Gamber M,Wu J,He G

    更新日期:2020-06-01 00:00:00

  • Rhabdomyolysis as Potential Late Complication Associated with COVID-19.

    abstract::We describe a patient in Wuhan, China, with severe acute respiratory syndrome coronavirus 2 infection who had progressive pulmonary lesions and rhabdomyolysis with manifestations of lower limb pain and fatigue. Rapid clinical recognition of rhabdomyolysis symptoms in patients with severe acute respiratory syndrome cor...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2607.200445

    authors: Jin M,Tong Q

    更新日期:2020-07-01 00:00:00

  • Acute hemorrhagic conjunctivitis due to enterovirus 70 in India.

    abstract::An outbreak of acute hemorrhagic conjunctivitis occurred in Delhi, India, during August and September 1996. The etiologic agent was confirmed as enterovirus type 70 by a modified centrifugation-enhanced culture method followed by immunofluorescence and neutralization tests. After nearly a decade, this virus is reemerg...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid0502.990212

    authors: Maitreyi RS,Dar L,Muthukumar A,Vajpayee M,Xess I,Vajpayee RB,Seth P,Broor S

    更新日期:1999-03-01 00:00:00

  • Antibodies against Borrelia burgdorferi sensu lato among Adults, Germany, 2008-2011.

    abstract::To assess Borrelia burgdorferi sensu lato (the cause of Lyme borreliosis) seropositivity in Germany, we tested serum samples from health survey (2008-2011) participants. Seroprevalence was 5.8% among women and 13.0% among men; infection risk was highest among persons >60 years of age. Public health interventions, incl...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2101.140009

    authors: Wilking H,Fingerle V,Klier C,Thamm M,Stark K

    更新日期:2015-01-01 00:00:00

  • Role of Environmental Factors in Shaping Spatial Distribution of Salmonella enterica Serovar Typhi, Fiji.

    abstract::Fiji recently experienced a sharp increase in reported typhoid fever cases. To investigate geographic distribution and environmental risk factors associated with Salmonella enterica serovar Typhi infection, we conducted a cross-sectional cluster survey with associated serologic testing for Vi capsular antigen-specific...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2402.170704

    authors: de Alwis R,Watson C,Nikolay B,Lowry JH,Thieu NTV,Van TT,Ngoc DTT,Rawalai K,Taufa M,Coriakula J,Lau CL,Nilles EJ,Edmunds WJ,Kama M,Baker S,Cano J

    更新日期:2018-02-01 00:00:00

  • In vitro host-cell susceptibility to Usutu virus.

    abstract::We investigated the susceptibility to Usutu virus (Flavivirus) of 13 permanent cell lines, 3 primary cell cultures, and chicken embryos. Vero, PK-15, and goose embryo fibroblast cells developed cytopathic effects; however, viral multiplication was detected in all mammalian cell types by immunohistochemical tests. Chic...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1102.041016

    authors: Bakonyi T,Lussy H,Weissenböck H,Hornyák A,Nowotny N

    更新日期:2005-02-01 00:00:00

  • Antigenic and molecular characterization of avian influenza A(H9N2) viruses, Bangladesh.

    abstract::Human infection with avian influenza A(H9N2) virus was identified in Bangladesh in 2011. Surveillance for influenza viruses in apparently healthy poultry in live-bird markets in Bangladesh during 2008-2011 showed that subtype H9N2 viruses are isolated year-round, whereas highly pathogenic subtype H5N1 viruses are co-i...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1909.130336

    authors: Shanmuganatham K,Feeroz MM,Jones-Engel L,Smith GJ,Fourment M,Walker D,McClenaghan L,Alam SM,Hasan MK,Seiler P,Franks J,Danner A,Barman S,McKenzie P,Krauss S,Webby RJ,Webster RG

    更新日期:2013-01-01 00:00:00

  • Diagnosis and Management of Borrelia turicatae Infection in Febrile Soldier, Texas, USA.

    abstract::In August 2015, a soldier returned from field exercises in Texas, USA, with nonspecific febrile illness. Culture and sequencing of spirochetes from peripheral blood diagnosed Borrelia turicatae infection. The patient recovered after receiving doxycycline. No illness occurred in asymptomatic soldiers potentially expose...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2305.162069

    authors: Christensen AM,Pietralczyk E,Lopez JE,Brooks C,Schriefer ME,Wozniak E,Stermole B

    更新日期:2017-05-01 00:00:00

  • Hepatitis E virus variant in farmed mink, Denmark.

    abstract::Hepatitis E virus (HEV) is a zoonotic virus for which pigs are the primary animal reservoir. To investigate whether HEV occurs in mink in Denmark, we screened feces and tissues from domestic and wild mink. Our finding of a novel HEV variant supports previous findings of HEV variants in a variety of species. ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1912.130614

    authors: Krog JS,Breum SØ,Jensen TH,Larsen LE

    更新日期:2013-12-01 00:00:00