Immunization with heterologous flaviviruses protective against fatal West Nile encephalitis.

Abstract:

:Prior immunization of hamsters with three heterologous flaviviruses (Japanese encephalitis virus [JEV] SA14-2-8 vaccine, wild-type St. Louis encephalitis virus [SLEV], and Yellow fever virus [YFV] 17D vaccine) reduces the severity of subsequent West Nile virus (WNV) infection. Groups of adult hamsters were immunized with each of the heterologous flaviviruses; approximately 30 days later, the animals were injected intraperitoneally with a virulent New York strain of WNV. Subsequent levels of viremia, antibody response, and deaths were compared with those in nonimmune (control) hamsters. Immunity to JEV and SLEV was protective against clinical encephalitis and death after challenge with WNV. The antibody response in the sequentially infected hamsters also illustrates the difficulty in making a serologic diagnosis of WNV infection in animals (or humans) with preexisting Flavivirus immunity.

journal_name

Emerg Infect Dis

authors

Tesh RB,Travassos da Rosa AP,Guzman H,Araujo TP,Xiao SY

doi

10.3201/eid0803.010238

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

245-51

issue

3

eissn

1080-6040

issn

1080-6059

journal_volume

8

pub_type

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