Invasive Nontuberculous Mycobacterial Infections among Cardiothoracic Surgical Patients Exposed to Heater-Cooler Devices1.

Abstract:

:Invasive nontuberculous mycobacteria (NTM) infections may result from a previously unrecognized source of transmission, heater-cooler devices (HCDs) used during cardiac surgery. In July 2015, the Pennsylvania Department of Health notified the Centers for Disease Control and Prevention (CDC) about a cluster of NTM infections among cardiothoracic surgical patients at 1 hospital. We conducted a case-control study to identify exposures causing infection, examining 11 case-patients and 48 control-patients. Eight (73%) case-patients had a clinical specimen identified as Mycobacterium avium complex (MAC). HCD exposure was associated with increased odds of invasive NTM infection; laboratory testing identified patient isolates and HCD samples as closely related strains of M. chimaera, a MAC species. This investigation confirmed a large US outbreak of invasive MAC infections in a previously unaffected patient population and suggested transmission occurred by aerosolization from HCDs. Recommendations have been issued for enhanced surveillance to identify potential infections associated with HCDs and measures to mitigate transmission risk.

journal_name

Emerg Infect Dis

authors

Lyman MM,Grigg C,Kinsey CB,Keckler MS,Moulton-Meissner H,Cooper E,Soe MM,Noble-Wang J,Longenberger A,Walker SR,Miller JR,Perz JF,Perkins KM

doi

10.3201/eid2305.161899

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

796-805

issue

5

eissn

1080-6040

issn

1080-6059

journal_volume

23

pub_type

杂志文章
  • Mycobacterium caprae Infection in Captive Borneo Elephant, Japan.

    abstract::In 2016, disseminated tuberculosis caused by Mycobacterium caprae was diagnosed in a captive Borneo elephant in Japan. The bacterium was initially identified from clinical isolates. An isolate collected during a relapse showed isoniazid monoresistance and a codon 315 katG mutation. ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2410.180018

    authors: Yoshida S,Suga S,Ishikawa S,Mukai Y,Tsuyuguchi K,Inoue Y,Yamamoto T,Wada T

    更新日期:2018-10-01 00:00:00

  • Seroepidemiology of Human Enterovirus 71 Infection among Children, Cambodia.

    abstract::Enterovirus 71 is reported to have emerged in Cambodia in 2012; at least 54 children with severe encephalitis died during that outbreak. We used serum samples collected during 2000-2011 to show that the virus had been widespread in the country for at least a decade before the 2012 outbreak. ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2201.151323

    authors: Horwood PF,Andronico A,Tarantola A,Salje H,Duong V,Mey C,Ly S,Dussart P,Cauchemez S,Buchy P

    更新日期:2016-01-01 00:00:00

  • Fatal Case of Chronic Jamestown Canyon Virus Encephalitis Diagnosed by Metagenomic Sequencing in Patient Receiving Rituximab.

    abstract::A 56-year-old man receiving rituximab who had months of neurologic symptoms was found to have Jamestown Canyon virus in cerebrospinal fluid by clinical metagenomic sequencing. The patient died, and postmortem examination revealed extensive neuropathologic abnormalities. Deep sequencing enabled detailed characterizatio...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2701.203448

    authors: Solomon IH,Ganesh VS,Yu G,Deng XD,Wilson MR,Miller S,Milligan TA,Mukerji SS,Mathewson A,Linxweiler J,Morse D,Ritter JM,Staples JE,Hughes H,Gould CV,Sabeti PC,Chiu CY,Piantadosi A

    更新日期:2021-01-01 00:00:00

  • Outcomes of Bedaquiline Treatment in Patients with Multidrug-Resistant Tuberculosis.

    abstract::Bedaquiline is recommended by the World Health Organization for the treatment of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB). We pooled data from 5 cohorts of patients treated with bedaquiline in France, Georgia, Armenia, and South Africa and in a multicountry study. The rate of cu...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2505.181823

    authors: Mbuagbaw L,Guglielmetti L,Hewison C,Bakare N,Bastard M,Caumes E,Fréchet-Jachym M,Robert J,Veziris N,Khachatryan N,Kotrikadze T,Hayrapetyan A,Avaliani Z,Schünemann HJ,Lienhardt C

    更新日期:2019-05-01 00:00:00

  • Characteristics of Staphylococcus aureus infections, Chicago Pediatric Hospital.

    abstract::Invasive and skin community-associated (CA)-methicillin-resistant Staphylococcus aureus isolates from children were matched with invasive CA-methicillin-sensitive S. aureus strains during 2000-2004. Isolates were analyzed for presence of Panton-Valentine leukocidin. A USA400 lineage clone (n = 6) and the predominant U...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1302.060295

    authors: Jaggi P,Paule SM,Peterson LR,Tan TQ

    更新日期:2007-02-01 00:00:00

  • Schmallenberg virus in Culicoides spp. biting midges, the Netherlands, 2011.

    abstract::To determine which species of Culicoides biting midges carry Schmallenberg virus (SBV), we assayed midges collected in the Netherlands during autumn 2011. SBV RNA was found in C. scoticus, C. obsoletus sensu stricto, and C. chiopterus. The high proportion of infected midges might explain the rapid spread of SBV throug...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1901.121054

    authors: Elbers AR,Meiswinkel R,van Weezep E,Sloet van Oldruitenborgh-Oosterbaan MM,Kooi EA

    更新日期:2013-01-01 00:00:00

  • rpoB Gene mutations in rifampin-resistant Mycobacterium tuberculosis identified by polymerase chain reaction single-stranded conformational polymorphism.

    abstract::The use of polymerase chain reaction-single-stranded conformational polymorphism (PCR-SSCP) to study rpoB gene mutations in rifampin-resistant (RIFr) Mycobacterium tuberculosis has yielded contradictory results. To determine the sensitivity of this method, we analyzed 35 RIFr strains and 11 rifampin-susceptible (RIFs)...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid0706.010615

    authors: Bobadilla-del-Valle M,Ponce-de-Leon A,Arenas-Huertero C,Vargas-Alarcon G,Kato-Maeda M,Small PM,Couary P,Ruiz-Palacios GM,Sifuentes-Osornio J

    更新日期:2001-11-01 00:00:00

  • Protective Immunity and Persistent Lung Sequelae in Domestic Cats after SARS-CoV-2 Infection.

    abstract::Severe acute respiratory syndrome coronavirus 2 readily transmits between domestic cats. We found that domestic cats that recover from an initial infection might be protected from reinfection. However, we found long-term persistence of inflammation and other lung lesions after infection, despite a lack of clinical sym...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2702.203884

    authors: Chiba S,Halfmann PJ,Hatta M,Maemura T,Fan S,Armbrust T,Swartley OM,Crawford LK,Kawaoka Y

    更新日期:2021-02-01 00:00:00

  • Trends in Population Dynamics of Escherichia coli Sequence Type 131, Calgary, Alberta, Canada, 2006-20161.

    abstract::Global expansion of antimicrobial drug-resistant Escherichia coli sequence type (ST) 131 is unrivaled among human bacteria. Understanding trends among ST131 clades will help with designing prevention strategies. We screened E. coli from blood samples (n = 1,784) obtained in Calgary, Alberta, Canada, during 2006, 2012,...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2612.201221

    authors: Peirano G,Lynch T,Matsumara Y,Nobrega D,Finn TJ,DeVinney R,Pitout JDD

    更新日期:2020-12-01 00:00:00

  • Distribution of eosinophilic meningitis cases attributable to Angiostrongylus cantonensis, Hawaii.

    abstract::During November 2004-January 2005, 5 cases of eosinophilic meningitis (EM) attributable to Angiostrongylus cantonensis infection were reported in Hawaii. To determine if this temporal clustering reflected an increased incidence, we ascertained EM and A. cantonensis cases by systematic review of statewide laboratory an...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1311.070367

    authors: Hochberg NS,Park SY,Blackburn BG,Sejvar JJ,Gaynor K,Chung H,Leniek K,Herwaldt BL,Effler PV

    更新日期:2007-11-01 00:00:00

  • Etiology of Severe Acute Respiratory Infections, Bangladesh, 2017.

    abstract::In April 2017, surveillance detected a surge in severe acute respiratory infections (SARI) in Bangladesh. We collected specimens from SARI patients and asymptomatic controls for analysis with multipathogen diagnostic tests. Influenza A(H1N1)pdm09 was associated with the SARI epidemic, suggesting that introducing vacci...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2701.201347

    authors: Rahaman MR,Alroy KA,Van Beneden CA,Friedman MS,Kennedy ED,Rahman M,Balajee A,Muraduzzaman AKM,Shirin T,Flora MS,Azziz-Baumgartner E

    更新日期:2021-01-01 00:00:00

  • Highly Pathogenic Avian Influenza Virus (H5N8) Clade 2.3.4.4 Infection in Migratory Birds, Egypt.

    abstract::We isolated highly pathogenic avian influenza virus (H5N8) of clade 2.3.4.4 from the common coot (Fulica atra) in Egypt, documenting its introduction into Africa through migratory birds. This virus has a close genetic relationship with subtype H5N8 viruses circulating in Europe. Enhanced surveillance to detect newly e...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2306.162056

    authors: Selim AA,Erfan AM,Hagag N,Zanaty A,Samir AH,Samy M,Abdelhalim A,Arafa AA,Soliman MA,Shaheen M,Ibraheem EM,Mahrous I,Hassan MK,Naguib MM

    更新日期:2017-06-01 00:00:00

  • Spread of Cryptococcus gattii into Pacific Northwest region of the United States.

    abstract::Cryptococcus gattii has emerged as a human and animal pathogen in the Pacific Northwest. First recognized on Vancouver Island, British Columbia, Canada, it now involves mainland British Columbia, and Washington and Oregon in the United States. In Canada, the incidence of disease has been one of the highest worldwide. ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章,评审

    doi:10.3201/eid1508.081384

    authors: Datta K,Bartlett KH,Baer R,Byrnes E,Galanis E,Heitman J,Hoang L,Leslie MJ,MacDougall L,Magill SS,Morshed MG,Marr KA,Cryptococcus gattii Working Group of the Pacific Northwest.

    更新日期:2009-08-01 00:00:00

  • Naturally Acquired Human Plasmodium cynomolgi and P. knowlesi Infections, Malaysian Borneo.

    abstract::To monitor the incidence of Plasmodium knowlesi infections and determine whether other simian malaria parasites are being transmitted to humans, we examined 1,047 blood samples from patients with malaria at Kapit Hospital in Kapit, Malaysia, during June 24, 2013-December 31, 2017. Using nested PCR assays, we found 845...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2608.200343

    authors: Raja TN,Hu TH,Kadir KA,Mohamad DSA,Rosli N,Wong LL,Hii KC,Simon Divis PC,Singh B

    更新日期:2020-08-01 00:00:00

  • Acute Flaccid Myelitis Associated with Enterovirus D68 in Children, Argentina, 2016.

    abstract::After a 2014 outbreak of severe respiratory illness caused by enterovirus D68 in the United States, sporadic cases of acute flaccid myelitis have been reported worldwide. We describe a cluster of acute flaccid myelitis cases in Argentina in 2016, adding data to the evidence of association between enterovirus D68 and t...

    journal_title:Emerging infectious diseases

    pub_type: 历史文章,杂志文章

    doi:10.3201/eid2503.170897

    authors: Carballo CM,Erro MG,Sordelli N,Vazquez G,Mistchenko AS,Cejas C,Rodriguez M,Cisterna DM,Freire MC,Contrini MM,Lopez EL

    更新日期:2019-03-01 00:00:00

  • Metagenomics of Imported Multidrug-Resistant Mycobacterium leprae, Saudi Arabia, 2017.

    abstract::Using shotgun metagenomics, we identified an imported case of multidrug-resistant Mycobacterium leprae in a Filipino resident of Saudi Arabia in 2017. We determined the phylogenomic lineage (3K1) and identified mutations in rpoB and rrs corresponding to the multidrug-resistance phenotype clinically observed. Metagenom...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2603.190661

    authors: Guan Q,Almutairi TS,Alhalouli T,Pain A,Alasmari F

    更新日期:2020-03-01 00:00:00

  • Staphylococcus aureus Colonization and Long-Term Risk for Death, United States.

    abstract::To examine the association of colonization by Staphylococcus aureus and general population mortality, we followed 10,598 adults for 8.5 years on average. Methicillin-susceptible S. aureus colonization was not associated with death. Methicillin-resistant S. aureus carriage predicted death in a crude analysis but not af...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2211.160220

    authors: Mendy A,Vieira ER,Albatineh AN,Gasana J

    更新日期:2016-11-01 00:00:00

  • Ehrlichia chaffeensis infections among HIV-infected patients in a human monocytic ehrlichiosis-endemic area.

    abstract::Manifestations of human monocytic ehrlichiosis (HME), a tick-borne infection caused by Ehrlichia chaffeensis, range from asymptomatic disease to fulminant infection and may be particularly severe in persons infected with HIV. We conducted a serologic study to determine the epidemiology of HME in HIV-positive patients ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid0909.020560

    authors: Talbot TR,Comer JA,Bloch KC

    更新日期:2003-09-01 00:00:00

  • Sporadic cryptosporidiosis, North Cumbria, England, 1996-2000.

    abstract::Risk factors for sporadic cryptosporidiosis were determined in 152 patients and 466 unmatched controls who resided in two local government districts in North Cumbria, North West England, from March 1, 1996, to February 29, 2000. Risk was associated with the usual daily volume of cold unboiled tap water drunk (odds rat...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/10.3201/eid1006.030325

    authors: Goh S,Reacher M,Casemore DP,Verlander NQ,Chalmers R,Knowles M,Williams J,Osborn K,Richards S

    更新日期:2004-06-01 00:00:00

  • Invasive group a streptococcal disease in nursing homes, Minnesota, 1995-2006.

    abstract::Nursing home residents are at high risk for invasive group A streptococcal (GAS) disease, and clusters of cases in nursing homes are common.To characterize the epidemiologic features of invasive GAS disease in nursing homes, we conducted active, statewide, population- and laboratory-based surveillance in Minnesota fro...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1405.070407

    authors: Rainbow J,Jewell B,Danila RN,Boxrud D,Beall B,Van Beneden C,Lynfield R

    更新日期:2008-05-01 00:00:00

  • Shift in Staphylococcus aureus clone linked to an infected tattoo.

    abstract::A retrospective investigation of skin and soft tissue infections caused by community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains among inmates in a Wisconsin correctional facility suggested a shift in MRSA genotype. Case timeline indicated a displacement of USA400 clone by USA300 clone. The U...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1209.051634

    authors: Stemper ME,Brady JM,Qutaishat SS,Borlaug G,Reed J,Reed KD,Shukla SK

    更新日期:2006-09-01 00:00:00

  • Detection and Genotyping of Coxiella burnetii in Pigs, South Korea, 2014-2015.

    abstract::We assessed Coxiella burnetii prevalence and genotypes in pigs in South Korea during 2014-2015. Prevalence was low among 1,030 samples tested by ELISA and immunofluorescent assay and 1,124 samples tested by PCR. Despite this finding, possible transmission of C. burnetii from pigs to humans cannot be excluded. ...

    journal_title:Emerging infectious diseases

    pub_type: 历史文章,杂志文章

    doi:10.3201/eid2212.161236

    authors: Seo MG,Ouh IO,Lee SH,Kwak D

    更新日期:2016-12-01 00:00:00

  • Clinical assessment and improved diagnosis of bocavirus-induced wheezing in children, Finland.

    abstract::Human bocavirus (HBoV) is a widespread respiratory virus. To improve diagnostic methods, we conducted immunoglobulin (Ig) G and IgM enzyme immunoassays with recombinant virus-like particles of HBoV as antigen. Acute-phase and follow-up serum samples from 258 wheezing children and single serum samples from 115 healthy ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1509.090204

    authors: Söderlund-Venermo M,Lahtinen A,Jartti T,Hedman L,Kemppainen K,Lehtinen P,Allander T,Ruuskanen O,Hedman K

    更新日期:2009-09-01 00:00:00

  • Possible Role of Rickettsia felis in Acute Febrile Illness among Children in Gabon.

    abstract::Rickettsia felis has been reported to be a cause of fever in sub-Saharan Africa, but this association has been poorly evaluated in Gabon. We assessed the prevalence of this bacterium among children <15 years of age in 4 areas of Gabon; the locations were in urban, semiurban, and rural areas. DNA samples from 410 febri...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2110.141825

    authors: Mourembou G,Lekana-Douki JB,Mediannikov O,Nzondo SM,Kouna LC,Essone JC,Fenollar F,Raoult D

    更新日期:2015-10-01 00:00:00

  • Transmission of Babesia microti Parasites by Solid Organ Transplantation.

    abstract::Babesia microti, an intraerythrocytic parasite, is tickborne in nature. In contrast to transmission by blood transfusion, which has been well documented, transmission associated with solid organ transplantation has not been reported. We describe parasitologically confirmed cases of babesiosis diagnosed ≈8 weeks posttr...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2211.151028

    authors: Brennan MB,Herwaldt BL,Kazmierczak JJ,Weiss JW,Klein CL,Leith CP,He R,Oberley MJ,Tonnetti L,Wilkins PP,Gauthier GM

    更新日期:2016-11-01 00:00:00

  • Hepatitis E in England and Wales.

    abstract::In 2005, 329 cases of hepatitis E virus infection were confirmed in England and Wales; 33 were confirmed indigenous infections, and a further 67 were estimated to be indigenous infections. Hepatitis E should be considered in the investigation of patients with hepatitis even if they have no history of travel. ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1401.070307

    authors: Lewis HC,Boisson S,Ijaz S,Hewitt K,Ngui SL,Boxall E,Teo CG,Morgan D

    更新日期:2008-01-01 00:00:00

  • Can managed health care help manage health care-associated infections?

    abstract::Managed-care organizations have a unique opportunity, still largely unrealized, to collaborate with health-care providers and epidemiologists to prevent health care-associated infections. Several attributes make these organizations logical collaborators for infection control programs: they have responsibility for defi...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid0702.010243

    authors: Platt R,Caldwell B

    更新日期:2001-03-01 00:00:00

  • Characterization of Nipah virus from naturally infected Pteropus vampyrus bats, Malaysia.

    abstract::We isolated and characterized Nipah virus (NiV) from Pteropus vampyrus bats, the putative reservoir for the 1998 outbreak in Malaysia, and provide evidence of viral recrudescence. This isolate is monophyletic with previous NiVs in combined analysis, and the nucleocapsid gene phylogeny species. ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1612.091790

    authors: Rahman SA,Hassan SS,Olival KJ,Mohamed M,Chang LY,Hassan L,Saad NM,Shohaimi SA,Mamat ZC,Naim MS,Epstein JH,Suri AS,Field HE,Daszak P,Henipavirus Ecology Research Group.

    更新日期:2010-12-01 00:00:00

  • Avian influenza vaccination of poultry and passive case reporting, Egypt.

    abstract::We investigated the influence of a mass poultry vaccination campaign on passive surveillance of highly pathogenic avian influenza subtype (H5N1) outbreaks among poultry in Egypt. Passive reporting dropped during the campaign, although probability of infection remained unchanged. Future poultry vaccination campaigns sh...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1812.120616

    authors: Vergne T,Grosbois V,Jobre Y,Saad A,El Nabi AA,Galal S,Kalifa M,El Kader SA,Dauphin G,Roger F,Lubroth J,Peyre M

    更新日期:2012-12-01 00:00:00

  • Strongyloidiasis and Culture-Negative Suppurative Meningitis, Japan, 1993-2015.

    abstract::Community-acquired Enterobacteriaceae infection and culture-negative meningitis are rare and atypical subtypes of meningitis in adults. Of 37 patients who had atypical suppurative meningitis during 1993-2015 in Okinawa, Japan, 54.5% had strongyloidiasis, of which 9.1% cases were hyperinfections and 3.0% dissemination....

    journal_title:Emerging infectious diseases

    pub_type: 历史文章,信件

    doi:10.3201/eid2412.180375

    authors: Mukaigawara M,Nakayama I,Gibo K

    更新日期:2018-12-01 00:00:00