Abstract:
:Invasive nontuberculous mycobacteria (NTM) infections may result from a previously unrecognized source of transmission, heater-cooler devices (HCDs) used during cardiac surgery. In July 2015, the Pennsylvania Department of Health notified the Centers for Disease Control and Prevention (CDC) about a cluster of NTM infections among cardiothoracic surgical patients at 1 hospital. We conducted a case-control study to identify exposures causing infection, examining 11 case-patients and 48 control-patients. Eight (73%) case-patients had a clinical specimen identified as Mycobacterium avium complex (MAC). HCD exposure was associated with increased odds of invasive NTM infection; laboratory testing identified patient isolates and HCD samples as closely related strains of M. chimaera, a MAC species. This investigation confirmed a large US outbreak of invasive MAC infections in a previously unaffected patient population and suggested transmission occurred by aerosolization from HCDs. Recommendations have been issued for enhanced surveillance to identify potential infections associated with HCDs and measures to mitigate transmission risk.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Lyman MM,Grigg C,Kinsey CB,Keckler MS,Moulton-Meissner H,Cooper E,Soe MM,Noble-Wang J,Longenberger A,Walker SR,Miller JR,Perz JF,Perkins KMdoi
10.3201/eid2305.161899subject
Has Abstractpub_date
2017-05-01 00:00:00pages
796-805issue
5eissn
1080-6040issn
1080-6059journal_volume
23pub_type
杂志文章abstract::In 2016, disseminated tuberculosis caused by Mycobacterium caprae was diagnosed in a captive Borneo elephant in Japan. The bacterium was initially identified from clinical isolates. An isolate collected during a relapse showed isoniazid monoresistance and a codon 315 katG mutation. ...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid2410.180018
更新日期:2018-10-01 00:00:00
abstract::Enterovirus 71 is reported to have emerged in Cambodia in 2012; at least 54 children with severe encephalitis died during that outbreak. We used serum samples collected during 2000-2011 to show that the virus had been widespread in the country for at least a decade before the 2012 outbreak. ...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid2201.151323
更新日期:2016-01-01 00:00:00
abstract::A 56-year-old man receiving rituximab who had months of neurologic symptoms was found to have Jamestown Canyon virus in cerebrospinal fluid by clinical metagenomic sequencing. The patient died, and postmortem examination revealed extensive neuropathologic abnormalities. Deep sequencing enabled detailed characterizatio...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid2701.203448
更新日期:2021-01-01 00:00:00
abstract::Bedaquiline is recommended by the World Health Organization for the treatment of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB). We pooled data from 5 cohorts of patients treated with bedaquiline in France, Georgia, Armenia, and South Africa and in a multicountry study. The rate of cu...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid2505.181823
更新日期:2019-05-01 00:00:00
abstract::Invasive and skin community-associated (CA)-methicillin-resistant Staphylococcus aureus isolates from children were matched with invasive CA-methicillin-sensitive S. aureus strains during 2000-2004. Isolates were analyzed for presence of Panton-Valentine leukocidin. A USA400 lineage clone (n = 6) and the predominant U...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1302.060295
更新日期:2007-02-01 00:00:00
abstract::To determine which species of Culicoides biting midges carry Schmallenberg virus (SBV), we assayed midges collected in the Netherlands during autumn 2011. SBV RNA was found in C. scoticus, C. obsoletus sensu stricto, and C. chiopterus. The high proportion of infected midges might explain the rapid spread of SBV throug...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1901.121054
更新日期:2013-01-01 00:00:00
abstract::The use of polymerase chain reaction-single-stranded conformational polymorphism (PCR-SSCP) to study rpoB gene mutations in rifampin-resistant (RIFr) Mycobacterium tuberculosis has yielded contradictory results. To determine the sensitivity of this method, we analyzed 35 RIFr strains and 11 rifampin-susceptible (RIFs)...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid0706.010615
更新日期:2001-11-01 00:00:00
abstract::Severe acute respiratory syndrome coronavirus 2 readily transmits between domestic cats. We found that domestic cats that recover from an initial infection might be protected from reinfection. However, we found long-term persistence of inflammation and other lung lesions after infection, despite a lack of clinical sym...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid2702.203884
更新日期:2021-02-01 00:00:00
abstract::Global expansion of antimicrobial drug-resistant Escherichia coli sequence type (ST) 131 is unrivaled among human bacteria. Understanding trends among ST131 clades will help with designing prevention strategies. We screened E. coli from blood samples (n = 1,784) obtained in Calgary, Alberta, Canada, during 2006, 2012,...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid2612.201221
更新日期:2020-12-01 00:00:00
abstract::During November 2004-January 2005, 5 cases of eosinophilic meningitis (EM) attributable to Angiostrongylus cantonensis infection were reported in Hawaii. To determine if this temporal clustering reflected an increased incidence, we ascertained EM and A. cantonensis cases by systematic review of statewide laboratory an...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1311.070367
更新日期:2007-11-01 00:00:00
abstract::In April 2017, surveillance detected a surge in severe acute respiratory infections (SARI) in Bangladesh. We collected specimens from SARI patients and asymptomatic controls for analysis with multipathogen diagnostic tests. Influenza A(H1N1)pdm09 was associated with the SARI epidemic, suggesting that introducing vacci...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid2701.201347
更新日期:2021-01-01 00:00:00
abstract::We isolated highly pathogenic avian influenza virus (H5N8) of clade 2.3.4.4 from the common coot (Fulica atra) in Egypt, documenting its introduction into Africa through migratory birds. This virus has a close genetic relationship with subtype H5N8 viruses circulating in Europe. Enhanced surveillance to detect newly e...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid2306.162056
更新日期:2017-06-01 00:00:00
abstract::Cryptococcus gattii has emerged as a human and animal pathogen in the Pacific Northwest. First recognized on Vancouver Island, British Columbia, Canada, it now involves mainland British Columbia, and Washington and Oregon in the United States. In Canada, the incidence of disease has been one of the highest worldwide. ...
journal_title:Emerging infectious diseases
pub_type: 杂志文章,评审
doi:10.3201/eid1508.081384
更新日期:2009-08-01 00:00:00
abstract::To monitor the incidence of Plasmodium knowlesi infections and determine whether other simian malaria parasites are being transmitted to humans, we examined 1,047 blood samples from patients with malaria at Kapit Hospital in Kapit, Malaysia, during June 24, 2013-December 31, 2017. Using nested PCR assays, we found 845...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid2608.200343
更新日期:2020-08-01 00:00:00
abstract::After a 2014 outbreak of severe respiratory illness caused by enterovirus D68 in the United States, sporadic cases of acute flaccid myelitis have been reported worldwide. We describe a cluster of acute flaccid myelitis cases in Argentina in 2016, adding data to the evidence of association between enterovirus D68 and t...
journal_title:Emerging infectious diseases
pub_type: 历史文章,杂志文章
doi:10.3201/eid2503.170897
更新日期:2019-03-01 00:00:00
abstract::Using shotgun metagenomics, we identified an imported case of multidrug-resistant Mycobacterium leprae in a Filipino resident of Saudi Arabia in 2017. We determined the phylogenomic lineage (3K1) and identified mutations in rpoB and rrs corresponding to the multidrug-resistance phenotype clinically observed. Metagenom...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid2603.190661
更新日期:2020-03-01 00:00:00
abstract::To examine the association of colonization by Staphylococcus aureus and general population mortality, we followed 10,598 adults for 8.5 years on average. Methicillin-susceptible S. aureus colonization was not associated with death. Methicillin-resistant S. aureus carriage predicted death in a crude analysis but not af...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid2211.160220
更新日期:2016-11-01 00:00:00
abstract::Manifestations of human monocytic ehrlichiosis (HME), a tick-borne infection caused by Ehrlichia chaffeensis, range from asymptomatic disease to fulminant infection and may be particularly severe in persons infected with HIV. We conducted a serologic study to determine the epidemiology of HME in HIV-positive patients ...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid0909.020560
更新日期:2003-09-01 00:00:00
abstract::Risk factors for sporadic cryptosporidiosis were determined in 152 patients and 466 unmatched controls who resided in two local government districts in North Cumbria, North West England, from March 1, 1996, to February 29, 2000. Risk was associated with the usual daily volume of cold unboiled tap water drunk (odds rat...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/10.3201/eid1006.030325
更新日期:2004-06-01 00:00:00
abstract::Nursing home residents are at high risk for invasive group A streptococcal (GAS) disease, and clusters of cases in nursing homes are common.To characterize the epidemiologic features of invasive GAS disease in nursing homes, we conducted active, statewide, population- and laboratory-based surveillance in Minnesota fro...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1405.070407
更新日期:2008-05-01 00:00:00
abstract::A retrospective investigation of skin and soft tissue infections caused by community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains among inmates in a Wisconsin correctional facility suggested a shift in MRSA genotype. Case timeline indicated a displacement of USA400 clone by USA300 clone. The U...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1209.051634
更新日期:2006-09-01 00:00:00
abstract::We assessed Coxiella burnetii prevalence and genotypes in pigs in South Korea during 2014-2015. Prevalence was low among 1,030 samples tested by ELISA and immunofluorescent assay and 1,124 samples tested by PCR. Despite this finding, possible transmission of C. burnetii from pigs to humans cannot be excluded. ...
journal_title:Emerging infectious diseases
pub_type: 历史文章,杂志文章
doi:10.3201/eid2212.161236
更新日期:2016-12-01 00:00:00
abstract::Human bocavirus (HBoV) is a widespread respiratory virus. To improve diagnostic methods, we conducted immunoglobulin (Ig) G and IgM enzyme immunoassays with recombinant virus-like particles of HBoV as antigen. Acute-phase and follow-up serum samples from 258 wheezing children and single serum samples from 115 healthy ...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1509.090204
更新日期:2009-09-01 00:00:00
abstract::Rickettsia felis has been reported to be a cause of fever in sub-Saharan Africa, but this association has been poorly evaluated in Gabon. We assessed the prevalence of this bacterium among children <15 years of age in 4 areas of Gabon; the locations were in urban, semiurban, and rural areas. DNA samples from 410 febri...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid2110.141825
更新日期:2015-10-01 00:00:00
abstract::Babesia microti, an intraerythrocytic parasite, is tickborne in nature. In contrast to transmission by blood transfusion, which has been well documented, transmission associated with solid organ transplantation has not been reported. We describe parasitologically confirmed cases of babesiosis diagnosed ≈8 weeks posttr...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid2211.151028
更新日期:2016-11-01 00:00:00
abstract::In 2005, 329 cases of hepatitis E virus infection were confirmed in England and Wales; 33 were confirmed indigenous infections, and a further 67 were estimated to be indigenous infections. Hepatitis E should be considered in the investigation of patients with hepatitis even if they have no history of travel. ...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1401.070307
更新日期:2008-01-01 00:00:00
abstract::Managed-care organizations have a unique opportunity, still largely unrealized, to collaborate with health-care providers and epidemiologists to prevent health care-associated infections. Several attributes make these organizations logical collaborators for infection control programs: they have responsibility for defi...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid0702.010243
更新日期:2001-03-01 00:00:00
abstract::We isolated and characterized Nipah virus (NiV) from Pteropus vampyrus bats, the putative reservoir for the 1998 outbreak in Malaysia, and provide evidence of viral recrudescence. This isolate is monophyletic with previous NiVs in combined analysis, and the nucleocapsid gene phylogeny species. ...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1612.091790
更新日期:2010-12-01 00:00:00
abstract::We investigated the influence of a mass poultry vaccination campaign on passive surveillance of highly pathogenic avian influenza subtype (H5N1) outbreaks among poultry in Egypt. Passive reporting dropped during the campaign, although probability of infection remained unchanged. Future poultry vaccination campaigns sh...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1812.120616
更新日期:2012-12-01 00:00:00
abstract::Community-acquired Enterobacteriaceae infection and culture-negative meningitis are rare and atypical subtypes of meningitis in adults. Of 37 patients who had atypical suppurative meningitis during 1993-2015 in Okinawa, Japan, 54.5% had strongyloidiasis, of which 9.1% cases were hyperinfections and 3.0% dissemination....
journal_title:Emerging infectious diseases
pub_type: 历史文章,信件
doi:10.3201/eid2412.180375
更新日期:2018-12-01 00:00:00