Genetic characterization of hantaviruses transmitted by the Korean field mouse (Apodemus peninsulae), Far East Russia.

Abstract:

:In an epizootiologic survey of 122 rodents captured in Vladivostok, Russia, antibodies positive for hantavirus were found in Apodemus peninsulae (4/70), A. agrarius (1/39), and Clethrionomys rufocanus (1/8). The hantavirus sequences identified in two seropositive A. peninsulae and two patients with hemorrhagic fever with renal syndrome (HFRS) from the Primorye region of Far East Russia were designated as Solovey and Primorye, respectively. The nucleotide sequences of the Solovey, Primorye, and Amur (obtained through GenBank) sequences were closely related (>92% identity). Solovey and Primorye sequences shared 84% nucleotide identity with the prototype Hantaan 76-118. Phylogenetic analysis also indicated a close relationship between Solovey, Primorye, Amur, and other viruses identified in Russia, China, and Korea. Our findings suggest that the Korean field mouse (A. peninsulae) is the reservoir for a hantavirus that causes HFRS over a vast area of east Asia, including Far East Russia.

journal_name

Emerg Infect Dis

authors

Lokugamage K,Kariwa H,Hayasaka D,Cui BZ,Iwasaki T,Lokugamage N,Ivanov LI,Volkov VI,Demenev VA,Slonova R,Kompanets G,Kushnaryova T,Kurata T,Maeda K,Araki K,Mizutani T,Yoshimatsu K,Arikawa J,Takashima I

doi

10.3201/eid0808.010494

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

768-76

issue

8

eissn

1080-6040

issn

1080-6059

journal_volume

8

pub_type

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