Abstract:
:Human metapneumovirus (HMPV) is a newly discovered pathogen thought to be associated with respiratory disease. We report the results of a study of 587 children hospitalized with respiratory infection over a 13-month period. HMPV was detected in the nasopharyngeal aspirates from 32 (5.5%) children by reverse transcription-polymerase chain reaction. HMPV infection was associated with clinical diagnoses of pneumonia (36%), asthma exacerbation (23%), or acute bronchiolitis (10%). When compared to those with respiratory syncytial virus infection, children with HMPV infection were older, and wheezing was more likely to represent asthma exacerbation rather than acute bronchiolitis. HMPV viral activity peaked during the spring-summer period in Hong Kong. Phylogenetically, all HMPV virus strains from Hong Kong belonged to one of the two genetic lineages previously described. HMPV contributed to 441.6 hospital admissions per 100,000 population <6 years of age.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Peiris JS,Tang WH,Chan KH,Khong PL,Guan Y,Lau YL,Chiu SSdoi
10.3201/eid0906.030009subject
Has Abstractpub_date
2003-06-01 00:00:00pages
628-33issue
6eissn
1080-6040issn
1080-6059journal_volume
9pub_type
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