Abstract:
:“Mycobacterium canettii,” an opportunistic human pathogen living in an unknown environmental reservoir, is the progenitor species from which Mycobacterium tuberculosis emerged. Since its discovery in 1969, most of the ≈70 known M. canettii strains were isolated in the Republic of Djibouti, frequently from expatriate children and adults. We show here, by whole-genome sequencing, that most strains collected from February 2010 through March 2013, and associated with 2 outbreaks of lymph node tuberculosis in children, belong to a unique epidemic clone within M. canettii. Evolution of this clone, which has been recovered regularly since 1983, may mimic the birth of M. tuberculosis. Thus, recognizing this organism and identifying its reservoir are clinically important.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Blouin Y,Cazajous G,Dehan C,Soler C,Vong R,Hassan MO,Hauck Y,Boulais C,Andriamanantena D,Martinaud C,Martin É,Pourcel C,Vergnaud Gdoi
10.3201/eid2001.130652subject
Has Abstractpub_date
2014-01-01 00:00:00pages
21-8issue
1eissn
1080-6040issn
1080-6059journal_volume
20pub_type
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