Progenitor “Mycobacterium canettii” clone responsible for lymph node tuberculosis epidemic, Djibouti.

Abstract:

:“Mycobacterium canettii,” an opportunistic human pathogen living in an unknown environmental reservoir, is the progenitor species from which Mycobacterium tuberculosis emerged. Since its discovery in 1969, most of the ≈70 known M. canettii strains were isolated in the Republic of Djibouti, frequently from expatriate children and adults. We show here, by whole-genome sequencing, that most strains collected from February 2010 through March 2013, and associated with 2 outbreaks of lymph node tuberculosis in children, belong to a unique epidemic clone within M. canettii. Evolution of this clone, which has been recovered regularly since 1983, may mimic the birth of M. tuberculosis. Thus, recognizing this organism and identifying its reservoir are clinically important.

journal_name

Emerg Infect Dis

authors

Blouin Y,Cazajous G,Dehan C,Soler C,Vong R,Hassan MO,Hauck Y,Boulais C,Andriamanantena D,Martinaud C,Martin É,Pourcel C,Vergnaud G

doi

10.3201/eid2001.130652

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

21-8

issue

1

eissn

1080-6040

issn

1080-6059

journal_volume

20

pub_type

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