Abstract:
:Mycobacterium tuberculosis strains that are resistant to an increasing number of second-line drugs used to treat multidrug-resistant tuberculosis (MDR TB) are becoming a threat to public health worldwide. We surveyed the Network of Supranational Reference Laboratories for M. tuberculosis isolates that were resistant to second-line anti-TB drugs during 2000-2004. We defined extensively drug-resistant TB (XDR TB) as MDR TB with further resistance to > or = 3 of the 6 classes of second-line drugs. Of 23 eligible laboratories, 14 (61%) contributed data on 17,690 isolates, which reflected drug susceptibility results from 48 countries. Of 3,520 (19.9%) MDR TB isolates, 347 (9.9%) met criteria for XDR TB. Further investigation of population-based trends and expanded efforts to prevent drug resistance and effectively treat patients with MDR TB are crucial for protection of public health and control of TB.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Shah NS,Wright A,Bai GH,Barrera L,Boulahbal F,Martín-Casabona N,Drobniewski F,Gilpin C,Havelková M,Lepe R,Lumb R,Metchock B,Portaels F,Rodrigues MF,Rüsch-Gerdes S,Van Deun A,Vincent V,Laserson K,Wells C,Cegielski JPdoi
10.3201/eid1303.061400subject
Has Abstractpub_date
2007-03-01 00:00:00pages
380-7issue
3eissn
1080-6040issn
1080-6059journal_volume
13pub_type
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