Worldwide emergence of extensively drug-resistant tuberculosis.

Abstract:

:Mycobacterium tuberculosis strains that are resistant to an increasing number of second-line drugs used to treat multidrug-resistant tuberculosis (MDR TB) are becoming a threat to public health worldwide. We surveyed the Network of Supranational Reference Laboratories for M. tuberculosis isolates that were resistant to second-line anti-TB drugs during 2000-2004. We defined extensively drug-resistant TB (XDR TB) as MDR TB with further resistance to > or = 3 of the 6 classes of second-line drugs. Of 23 eligible laboratories, 14 (61%) contributed data on 17,690 isolates, which reflected drug susceptibility results from 48 countries. Of 3,520 (19.9%) MDR TB isolates, 347 (9.9%) met criteria for XDR TB. Further investigation of population-based trends and expanded efforts to prevent drug resistance and effectively treat patients with MDR TB are crucial for protection of public health and control of TB.

journal_name

Emerg Infect Dis

authors

Shah NS,Wright A,Bai GH,Barrera L,Boulahbal F,Martín-Casabona N,Drobniewski F,Gilpin C,Havelková M,Lepe R,Lumb R,Metchock B,Portaels F,Rodrigues MF,Rüsch-Gerdes S,Van Deun A,Vincent V,Laserson K,Wells C,Cegielski JP

doi

10.3201/eid1303.061400

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

380-7

issue

3

eissn

1080-6040

issn

1080-6059

journal_volume

13

pub_type

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