Mycobacterium abscessus and children with cystic fibrosis.

Abstract:

:We prospectively studied 298 patients with cystic fibrosis (mean age 11.3 years; range 2 months to 32 years; sex ratio, 0.47) for nontuberculous mycobacteria in respiratory samples from January 1, 1996, to December 31, 1999. Mycobacterium abscessus was by far the most prevalent nontuberculous mycobacterium: 15 patients (6 male, 9 female; mean age 11.9 years; range 2.5-22 years) had at least one positive sample for this microorganism (versus 6 patients positive for M. avium complex), including 10 with >3 positive samples (versus 3 patients for M. avium complex). The M. abscessus isolates from 14 patients were typed by pulsed-field gel electrophoresis: each of the 14 patients harbored a unique strain, ruling out a common environmental reservoir or person-to-person transmission. Water samples collected in the cystic fibrosis center were negative for M. abscessus. This major mycobacterial pathogen in children and teenagers with cystic fibrosis does not appear to be acquired nosocomially.

journal_name

Emerg Infect Dis

authors

Sermet-Gaudelus I,Le Bourgeois M,Pierre-Audigier C,Offredo C,Guillemot D,Halley S,Akoua-Koffi C,Vincent V,Sivadon-Tardy V,Ferroni A,Berche P,Scheinmann P,Lenoir G,Gaillard JL

doi

10.3201/eid0912.020774

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

1587-91

issue

12

eissn

1080-6040

issn

1080-6059

journal_volume

9

pub_type

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