Host genes and HIV: the role of the chemokine receptor gene CCR5 and its allele.

Abstract:

:Since the late 1970s, 8.4 million people worldwide, including 1.7 million children, have died of AIDS, and an estimated 22 million people are infected with human immunodeficiency virus (HIV)(1). During 1995 and 1996, major clinical and laboratory discoveries regarding HIV pathogenesis provided new hope for the prevention and treatment of HIV infection. One major discovery was that members of the chemokine receptor family serve as cofactors for HIV entry into cells. We describe the role of allelic polymorphism in the gene coding for the CCR5 chemokine receptor with regard to susceptibility to and disease course of HIV infection. We also examine the effect of this discovery on medical and public health practices.

journal_name

Emerg Infect Dis

authors

McNicholl JM,Smith DK,Qari SH,Hodge T

doi

10.3201/eid0303.970302

subject

Has Abstract

pub_date

1997-07-01 00:00:00

pages

261-71

issue

3

eissn

1080-6040

issn

1080-6059

journal_volume

3

pub_type

杂志文章,评审
  • Multicenter study of brucellosis in Egypt.

    abstract::Brucellosis causes appreciable economic losses in livestock. Examination of milk and tissues from animals in Egypt for Brucella spp. showed increased prevalence rates of serologically reactive animals. All isolates were B. melitensis biovar 3. One Brucella sp. was isolated from milk of serologically nonreactive buffal...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章,多中心研究

    doi:10.3201/eid1412.071452

    authors: Samaha H,Al-Rowaily M,Khoudair RM,Ashour HM

    更新日期:2008-12-01 00:00:00

  • Fatal Case of Chronic Jamestown Canyon Virus Encephalitis Diagnosed by Metagenomic Sequencing in Patient Receiving Rituximab.

    abstract::A 56-year-old man receiving rituximab who had months of neurologic symptoms was found to have Jamestown Canyon virus in cerebrospinal fluid by clinical metagenomic sequencing. The patient died, and postmortem examination revealed extensive neuropathologic abnormalities. Deep sequencing enabled detailed characterizatio...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2701.203448

    authors: Solomon IH,Ganesh VS,Yu G,Deng XD,Wilson MR,Miller S,Milligan TA,Mukerji SS,Mathewson A,Linxweiler J,Morse D,Ritter JM,Staples JE,Hughes H,Gould CV,Sabeti PC,Chiu CY,Piantadosi A

    更新日期:2021-01-01 00:00:00

  • Ebola and Its Control in Liberia, 2014-2015.

    abstract::The severe epidemic of Ebola virus disease in Liberia started in March 2014. On May 9, 2015, the World Health Organization declared Liberia free of Ebola, 42 days after safe burial of the last known case-patient. However, another 6 cases occurred during June-July; on September 3, 2015, the country was again declared f...

    journal_title:Emerging infectious diseases

    pub_type: 历史文章,杂志文章

    doi:10.3201/eid2202.151456

    authors: Nyenswah TG,Kateh F,Bawo L,Massaquoi M,Gbanyan M,Fallah M,Nagbe TK,Karsor KK,Wesseh CS,Sieh S,Gasasira A,Graaff P,Hensley L,Rosling H,Lo T,Pillai SK,Gupta N,Montgomery JM,Ransom RL,Williams D,Laney AS,Lindblade

    更新日期:2016-02-01 00:00:00

  • European Rabbits as Reservoir for Coxiella burnetii.

    abstract::We studied the role of European rabbits (Oryctolagus cuniculus) as a reservoir for Coxiella burnetii in the Iberian region. High individual and population seroprevalences observed in wild and farmed rabbits, evidence of systemic infections, and vaginal shedding support the reservoir role of the European rabbit for C. ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2106.141537

    authors: González-Barrio D,Maio E,Vieira-Pinto M,Ruiz-Fons F

    更新日期:2015-06-01 00:00:00

  • Common reservoirs for Penicillium marneffei infection in humans and rodents, China.

    abstract::Human penicilliosis marneffei is an emerging infectious disease caused by the fungus Penicillium marneffei. High prevalence of infection among bamboo rats of the genera Rhizomys and Cannomys suggest that these rodents are a key facet of the P. marneffei life cycle. We trapped bamboo rats during June 2004-July 2005 acr...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1702.100718

    authors: Cao C,Liang L,Wang W,Luo H,Huang S,Liu D,Xu J,Henk DA,Fisher MC

    更新日期:2011-02-01 00:00:00

  • Host-associated genetic import in Campylobacter jejuni.

    abstract::Host association of Campylobacter jejuni was analyzed by using multilocus sequence typing data for 713 isolates from chickens and bovids (cattle and sheep). Commonly used summary measures of genotypes (sequence type and clonal complex) showed poor accuracy, but a method using the full allelic profile showed 80% accura...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1302.060620

    authors: McCarthy ND,Colles FM,Dingle KE,Bagnall MC,Manning G,Maiden MC,Falush D

    更新日期:2007-02-01 00:00:00

  • Surface sampling methods for Bacillus anthracis spore contamination.

    abstract::During an investigation conducted December 17-20, 2001, we collected environmental samples from a U.S. postal facility in Washington, D.C., known to be extensively contaminated with Bacillus anthracis spores. Because methods for collecting and analyzing B. anthracis spores have not yet been validated, our objective wa...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid0810.020382

    authors: Sanderson WT,Hein MJ,Taylor L,Curwin BD,Kinnes GM,Seitz TA,Popovic T,Holmes HT,Kellum ME,McAllister SK,Whaley DN,Tupin EA,Walker T,Freed JA,Small DS,Klusaritz B,Bridges JH

    更新日期:2002-10-01 00:00:00

  • Hantaviruses: a global disease problem.

    abstract::Hantaviruses are carried by numerous rodent species throughout the world. In 1993, a previously unknown group of hantaviruses emerged in the United States as the cause of an acute respiratory disease now termed hantavirus pulmonary syndrome (HPS). Before than, hantaviruses were known as the etiologic agents of hemorrh...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章,评审

    doi:10.3201/eid0302.970202

    authors: Schmaljohn C,Hjelle B

    更新日期:1997-04-01 00:00:00

  • Rhabdomyolysis as Potential Late Complication Associated with COVID-19.

    abstract::We describe a patient in Wuhan, China, with severe acute respiratory syndrome coronavirus 2 infection who had progressive pulmonary lesions and rhabdomyolysis with manifestations of lower limb pain and fatigue. Rapid clinical recognition of rhabdomyolysis symptoms in patients with severe acute respiratory syndrome cor...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2607.200445

    authors: Jin M,Tong Q

    更新日期:2020-07-01 00:00:00

  • Molecular analysis of fluoroquinolone-resistant Salmonella Paratyphi A isolate, India.

    abstract::Salmonella enterica serovar Paratyphi A is increasingly a cause of enteric fever. Sequence analysis of an Indian isolate showed a unique strain with high-level resistance to ciprofloxacin associated with double mutations in the DNA gyrase subunit gyrA (Ser83-->Phe and Asp87-->Gly) and a mutation in topoisomerase IV su...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1205.050560

    authors: Nair S,Unnikrishnan M,Turner K,Parija SC,Churcher C,Wain J,Harish N

    更新日期:2006-03-01 00:00:00

  • Possible interruption of malaria transmission, highland Kenya, 2007-2008.

    abstract::Highland areas where malaria transmission is unstable are targets for malaria elimination because transmission decreases to low levels during the dry season. In highland areas of Kipsamoite and Kapsisiywa, Kenya (population approximately 7,400 persons), annual household indoor residual spraying with a synthetic pyreth...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1512.090627

    authors: John CC,Riedesel MA,Magak NG,Lindblade KA,Menge DM,Hodges JS,Vulule JM,Akhwale W

    更新日期:2009-12-01 00:00:00

  • Immunization with heterologous flaviviruses protective against fatal West Nile encephalitis.

    abstract::Prior immunization of hamsters with three heterologous flaviviruses (Japanese encephalitis virus [JEV] SA14-2-8 vaccine, wild-type St. Louis encephalitis virus [SLEV], and Yellow fever virus [YFV] 17D vaccine) reduces the severity of subsequent West Nile virus (WNV) infection. Groups of adult hamsters were immunized w...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid0803.010238

    authors: Tesh RB,Travassos da Rosa AP,Guzman H,Araujo TP,Xiao SY

    更新日期:2002-03-01 00:00:00

  • Increased hospitalizations of elderly patients.

    abstract::This issue of Emerging Infectious Diseases contains 2 articles that report increases in England in the incidence of hospitalizations for specific diseases, one on pneumonias and the other on community-acquired staphylococcal diseases. Both articles report increases in disease among those >65 years of age. ...

    journal_title:Emerging infectious diseases

    pub_type: 评论,杂志文章

    doi:10.3201/eid1405.080218

    authors: Meltzer MI

    更新日期:2008-05-01 00:00:00

  • Dengue spatial and temporal patterns, French Guiana, 2001.

    abstract::To study a 2001 dengue fever outbreak in Iracoubo, French Guiana, we recorded the location of all patients' homes and the date when symptoms were first observed. A geographic information system (GIS) was used to integrate the patient-related information. The Knox test, a classic space-time analysis technique, was used...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1004.030186

    authors: Tran A,Deparis X,Dussart P,Morvan J,Rabarison P,Remy F,Polidori L,Gardon J

    更新日期:2004-04-01 00:00:00

  • Novel thogotovirus associated with febrile illness and death, United States, 2014.

    abstract::A previously healthy man from eastern Kansas, USA, sought medical care in late spring because of a history of tick bite, fever, and fatigue. The patient had thrombocytopenia and leukopenia and was given doxycycline for a presumed tickborne illness. His condition did not improve. Multiorgan failure developed, and he di...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2105.150150

    authors: Kosoy OI,Lambert AJ,Hawkinson DJ,Pastula DM,Goldsmith CS,Hunt DC,Staples JE

    更新日期:2015-05-01 00:00:00

  • Third Wave of Influenza A(H7N9) Virus from Poultry, Guangdong Province, China, 2014-2015.

    abstract::Fourteen influenza A(H7N9) viruses were isolated from poultry or the environment in live poultry markets in Guangdong Province, China during 2014-2015. Phylogenetic analysis showed that all viruses were descended from viruses of the second wave of influenza A(H7N9) virus infections during 2013. These viruses can be di...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2109.150635

    authors: Xie S,Jia W,Lin Y,Xing K,Ren X,Qi W,Liao M

    更新日期:2015-09-01 00:00:00

  • Bacterial vaccines and serotype replacement: lessons from Haemophilus influenzae and prospects for Streptococcus pneumoniae.

    abstract::Conjugate vaccines have reduced the incidence of invasive disease caused by Haemophilus influenzae, type b (Hib), in industrialized countries and may be highly effective against Streptococcus pneumoniae. However, the serotype specificity of these vaccines has led to concern that their use may increase carriage of and ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid0503.990304

    authors: Lipsitch M

    更新日期:1999-05-01 00:00:00

  • Rickettsia felis in fleas, Western Australia.

    abstract::This study is the first confirmation of Rickettsia felis in Australia. The organism was identified from 4 species of fleas obtained from dogs and cats in Western Australia, by using polymerase chain reaction amplification and DNA sequencing of the citrate synthase and outer membrane protein A genes. ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1205.051458

    authors: Schloderer D,Owen H,Clark P,Stenos J,Fenwick SG

    更新日期:2006-05-01 00:00:00

  • Nosocomial bloodstream infection and clinical sepsis.

    abstract::Primary bloodstream infection (BSI) is a leading, preventable infectious complication in critically ill patients and has a negative impact on patients' outcome. Surveillance definitions for primary BSI distinguish those that are microbiologically documented from those that are not. The latter is known as clinical seps...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1001.030407

    authors: Hugonnet S,Sax H,Eggimann P,Chevrolet JC,Pittet D

    更新日期:2004-01-01 00:00:00

  • Methicillin-resistant Staphylococcus aureus, Western Australia.

    abstract::Methicillin-resistant Staphylococcus aureus (MRSA) continues to be a notable cause of hospital-acquired infections. A statewide screening and control policy was implemented in Western Australia (WA) after an outbreak of epidemic MRSA in a Perth hospital in 1982. We report on statutory notifications from 1998 to 2002 a...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1110.050125

    authors: Dailey L,Coombs GW,O'Brien FG,Pearman JW,Christiansen K,Grubb WB,Riley TV

    更新日期:2005-10-01 00:00:00

  • Cost-effectiveness of antiviral stockpiling and near-patient testing for potential influenza pandemic.

    abstract::A decision analytical model was developed to investigate the cost-effectiveness of stockpiling antiviral (AV) drugs for a potential influenza pandemic in the United Kingdom and the possible role of near-patient testing in conserving AV drug stocks. Under base-case assumptions (including a fixed stockpile that was smal...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1402.070478

    authors: Siddiqui MR,Edmunds WJ

    更新日期:2008-02-01 00:00:00

  • Exposure of domestic mammals to West Nile virus during an outbreak of human encephalitis, New York City, 1999.

    abstract::We evaluated West Nile (WN) virus seroprevalence in healthy horses, dogs, and cats in New York City after an outbreak of human WN virus encephalitis in 1999. Two (3%) of 73 horses, 10 (5%) of 189 dogs, and none of 12 cats tested positive for WN virus-neutralizing antibodies. Domestic mammals should be evaluated as sen...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid0704.010424

    authors: Komar N,Panella NA,Boyce E

    更新日期:2001-07-01 00:00:00

  • Hepatitis E outbreak on cruise ship.

    abstract::In 2008, acute hepatitis E infection was confirmed in 4 passengers returning to the United Kingdom after a world cruise. Epidemiologic investigation showed that of 789 persons who provided blood samples, 195 (25%) were seropositive, 33 (4%) had immunoglobulin [Ig] M levels consistent with recent acute infection (11 of...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1511.091094

    authors: Said B,Ijaz S,Kafatos G,Booth L,Thomas HL,Walsh A,Ramsay M,Morgan D,Hepatitis E Incident Investigation Team.

    更新日期:2009-11-01 00:00:00

  • Limited Dissemination of Extended-Spectrum β-Lactamase- and Plasmid-Encoded AmpC-Producing Escherichia coli from Food and Farm Animals, Sweden.

    abstract::Extended-spectrum β-lactamase (ESBL)- and plasmid-encoded ampC (pAmpC)-producing Enterobacteriaceae might spread from farm animals to humans through food. However, most studies have been limited in number of isolates tested and areas studied. We examined genetic relatedness of 716 isolates from 4,854 samples collected...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2204.151142

    authors: Börjesson S,Ny S,Egervärn M,Bergström J,Rosengren Å,Englund S,Löfmark S,Byfors S

    更新日期:2016-04-01 00:00:00

  • Evaluating human papillomavirus vaccination programs.

    abstract::Human papillomavirus (HPV) has been implicated as the primary etiologic agent of cervical cancer. Potential vaccines against high-risk HPV types are in clinical trials. We evaluated vaccination programs with a vaccine against HPV-16 and HPV-18. We developed disease transmission models that estimated HPV prevalence and...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1011.040222

    authors: Taira AV,Neukermans CP,Sanders GD

    更新日期:2004-11-01 00:00:00

  • Intermediate vancomycin susceptibility in a community-associated MRSA clone.

    abstract::We describe a case of treatment failure caused by a strain of USA300 community-associated methicillin-resistant Staphylococcus aureus (MRSA) with intermediate susceptibility to vancomycin and reduced susceptibility to daptomycin. The strain was isolated from the bone of a 56-year-old man with lumbar osteomyelitis afte...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1303.060960

    authors: Graber CJ,Wong MK,Carleton HA,Perdreau-Remington F,Haller BL,Chambers HF

    更新日期:2007-03-01 00:00:00

  • Molecular typing of Mycobacterium tuberculosis strains with a common two-band IS6110 pattern.

    abstract::We conducted a program of population-based molecular typing of all Mycobacterium tuberculosis isolates obtained in Alabama since 1994. Of 2452 isolates, 1013 (41%) had fewer than 6 bands of IS6110; 348 (14%) had a single two-band pattern (JH2). With conventional epidemiologic methods, we identified three groups of rel...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid0811.020292

    authors: Lok KH,Benjamin WH Jr,Kimerling ME,Pruitt V,Mulcahy D,Robinson N,Keenan NB,Dunlap NE

    更新日期:2002-11-01 00:00:00

  • Subclinical highly pathogenic avian influenza virus infection among vaccinated chickens, China.

    abstract::Subclinical infection of vaccinated chickens with a highly pathogenic avian influenza A(H5N2) virus was identified through routine surveillance in China. Investigation suggested that the virus has evolved into multiple genotypes. To better control transmission of the virus, we recommend a strengthened program of educa...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2012.140733

    authors: Ma QX,Jiang WM,Liu S,Wang SC,Zhuang QY,Hou GY,Liu XM,Sui ZH,Chen JM

    更新日期:2014-12-01 00:00:00

  • One health approach to influenza: assessment of critical issues and options.

    abstract::A task force of experts on influenza, public health, and animal health met at the conference One Health Approach to Influenza: Assessment of Critical Issues and Options in Washington, DC, on December 1-2, 2009. These experts discussed the role of the One Health approach in preparing for and responding to an influenza ...

    journal_title:Emerging infectious diseases

    pub_type: 共识发展会议,杂志文章

    doi:10.3201/eid1608.100673

    authors: Powdrill TF,Nipp TL,Rinderknecht JL

    更新日期:2010-08-01 00:00:00

  • Cumulative Incidence of West Nile Virus Infection, Continental United States, 1999-2016.

    abstract::Using reported case data from ArboNET and previous seroprevalence data stratified by age and sex, we conservatively estimate that ≈7 million persons in the United States have been infected with West Nile virus since its introduction in 1999. Our data support the need for public health interventions and improved survei...

    journal_title:Emerging infectious diseases

    pub_type: 历史文章,杂志文章

    doi:10.3201/eid2502.180765

    authors: Ronca SE,Murray KO,Nolan MS

    更新日期:2019-02-01 00:00:00