Abstract:
:Conjugate vaccines have reduced the incidence of invasive disease caused by Haemophilus influenzae, type b (Hib), in industrialized countries and may be highly effective against Streptococcus pneumoniae. However, the serotype specificity of these vaccines has led to concern that their use may increase carriage of and disease from serotypes not included in the vaccine. Replacement has not occurred with the use of Hib vaccines but has occurred in trials of pneumococcal vaccines. Mathematical models can be used to elucidate these contrasting outcomes, predict the conditions under which serotype replacement is likely, interpret the results of conjugate vaccine trials, design trials that will better detect serotype replacement (if it occurs), and suggest factors to consider in choosing the serotype composition of vaccines.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Lipsitch Mdoi
10.3201/eid0503.990304subject
Has Abstractpub_date
1999-05-01 00:00:00pages
336-45issue
3eissn
1080-6040issn
1080-6059journal_volume
5pub_type
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