Seroprevalence of trichodysplasia spinulosa-associated polyomavirus.

Abstract:

:We identified a new polyomavirus in skin lesions from a patient with trichodysplasia spinulosa (TS). Apart from TS being an extremely rare disease, little is known of its epidemiology. On the basis of knowledge regarding other polyomaviruses, we anticipated that infections with trichodysplasia spinulosa-associated polyomavirus (TSV) occur frequently and become symptomatic only in immunocompromised patients. To investigate this hypothesis, we developed and used a Luminex-based TSV viral protein 1 immunoassay, excluded cross-reactivity with phylogenetically related Merkel cell polyomavirus, and measured TSV seroreactivity. Highest reactivity was found in a TS patient. In 528 healthy persons in the Netherlands, a wide range of seroreactivities was measured and resulted in an overall TSV seroprevalence of 70% (range 10% in small children to 80% in adults). In 80 renal transplant patients, seroprevalence was 89%. Infection with the new TSV polyomavirus is common and occurs primarily at a young age.

journal_name

Emerg Infect Dis

authors

van der Meijden E,Kazem S,Burgers MM,Janssens R,Bouwes Bavinck JN,de Melker H,Feltkamp MC

doi

10.3201/eid1708.110114

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

1355-63

issue

8

eissn

1080-6040

issn

1080-6059

journal_volume

17

pub_type

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