Abstract:
:Chronic wasting disease (CWD) is a contagious and fatal neurodegenerative disease and a serious animal health issue for deer and elk in North America. The identification of the first cases of CWD among free-ranging reindeer and moose in Europe brings back into focus the unresolved issue of whether CWD can be zoonotic like bovine spongiform encephalopathy. We used a cell-free seeded protein misfolding assay to determine whether CWD prions from elk, white-tailed deer, and reindeer in North America can convert the human prion protein to the disease-associated form. We found that prions can convert, but the efficiency of conversion is affected by polymorphic variation in the cervid and human prion protein genes. In view of the similarity of reindeer, elk, and white-tailed deer in North America to reindeer, red deer, and roe deer, respectively, in Europe, a more comprehensive and thorough assessment of the zoonotic potential of CWD might be warranted.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Barria MA,Libori A,Mitchell G,Head MWdoi
10.3201/eid2408.161888subject
Has Abstractpub_date
2018-08-01 00:00:00pages
1482-1489issue
8eissn
1080-6040issn
1080-6059journal_volume
24pub_type
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