Identification and characterization of a Drosophila homologue of ATBP.

Abstract:

:ATBP [(A+T)-stretch binding protein] activates the Sarcophaga defense protein genes in an (A+T)-stretch dependent manner as shown previously using a luciferase reporter assay [Aozasa et al. (2001) Eur J Biochem, 268, 2506-2511]. We identified the Drosophila homologue of ATBP. Drosophila ATBP has 388 amino acid residues and the amino acid sequence has high similarity with that of the Sarcophaga ATBP. In particular, residues 1-56 and 301-374 are highly conserved between Sarcophaga and Drosophila. Drosophila ATBP activated the Sarcophaga lectin gene promoter in SL-2 cells. The Drosophila ATBP gene is a single copy gene and is located in the 20E region of chromosome X.

journal_name

Insect Mol Biol

journal_title

Insect molecular biology

authors

Aozasa N,Kubo T,Sekimizu K,Natori S

doi

10.1046/j.0962-1075.2001.00304.x

subject

Has Abstract

pub_date

2002-02-01 00:00:00

pages

31-6

issue

1

eissn

0962-1075

issn

1365-2583

pii

304

journal_volume

11

pub_type

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