Abstract：
:After injections of 6-hydroxydopamine (6-OHDA) along the medial forebrain bundle in the lateral hypothalamus, rats failed to acquire a one-way active avoidance response or failed to perform a previously acquired active avoidance response. Such rats, however, acquired a passive avoidance response and a conditioned taste aversion normally. Thus the effect of lateral hypothalamic injections of 6-OHDA was not a total loss of the capacity to acquire or perform conditioned responses, but was a failure to initiate forward movement in the presence of a conditional stimulus. Most of these rats could initiate a similar forward movement to escape from the unconditioned stimulus (foot shock). Failure to acquire or perform the active avoidance response was correlated with the loss of hypothalamic, striatal and forebrain catecholamines produced by lateral hypothalamic 6-OHDA injections. Identical injections of 6-ohda placed along the medial hypothalamus produced a similar loss of regional catecholamines, but medial 6-OHDA injections did not affect active avoidance responding. We interpret this dissociation between loss of catecholamines and the capacity for active avoidance responding to mean that medial 6-OHDA injections did not damage the same catecholaminergic terminal fields as lateral 6-OHDA injections and that the integrity of the terminal fields damaged by lateral 6-OHDA injections is necessary for active avoidance responding.
journal_name
Brain Resjournal_title
Brain researchauthors
Smith GP,Levin BE,Ervin GNdoi
10.1016/0006-8993(75)90659-9subject
Has Abstractpub_date
1975-05-09 00:00:00pages
483-98issue
3eissn
0006-8993issn
1872-6240pii
0006-8993(75)90659-9journal_volume
88pub_type
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