Mechanisms for contractile effect of Dai-kenchu-to in isolated guinea pig ileum.

Abstract:

:The mechanisms by which Dai-kenchu-to (TJ-100), a kampo medicine, enhances gastrointestinal motility was investigated using isolated guinea pig ileum. TJ-100 induced contractions accompanied by autonomous contraction at a concentration of more than 3 x 10(-4) g/ml in a dose-related manner. The TJ-100-induced ileal contraction was suppressed by atropine and tetrodotoxin, but not by hexamethonium. This effect was partially suppressed in the presence of high concentrations of ICS 205-930, a serotonin 4 (5-HT4) receptor antagonist. In addition, TJ-100 showed an acetylcholine (ACh)-releasing action in the smooth muscle tissues of ileum. These results suggest that contractile response induced by TJ-100 is partially mediated by ACh released from the cholinergic nerve endings and that 5-HT4 receptors would be involved in the effect of TJ-100.

journal_name

Dig Dis Sci

authors

Satoh K,Hayakawa T,Kase Y,Ishige A,Sasaki H,Nishikawa S,Kurosawa S,Yakabi K,Nakamura T

doi

10.1023/a:1005636412287

subject

Has Abstract

pub_date

2001-02-01 00:00:00

pages

250-6

issue

2

eissn

0163-2116

issn

1573-2568

journal_volume

46

pub_type

杂志文章
  • Outcomes of computed tomography and magnetic resonance enterography in clinical practice of inflammatory bowel disease.

    abstract:BACKGROUND:Computed tomography (CT) and magnetic resonance (MR) enterography are now widely used to diagnose and monitor Crohn's disease. AIM:We sought to assess the use of enterography for management of inflammatory bowel disease (IBD) in our medical center. METHODS:We performed a retrospective review of all patient...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-013-2964-7

    authors: Patel NS,Pola S,Muralimohan R,Zou GY,Santillan C,Patel D,Levesque BG,Sandborn WJ

    更新日期:2014-04-01 00:00:00

  • Prevalence of hepatitis C infection in a population of asymptomatic people in a checkup unit in Mexico city.

    abstract::Hepatitis C virus (HCV) infection has an estimated prevalence of 3% around the world. Unfortunately, many persons with HCV infection are asymptomatic. The aim of this study was to determine the prevalence of hepatitis C Virus infection in asymptomatic persons. This study was carried out in a population-based cross-sec...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-005-2565-1

    authors: Méndez-Sánchez N,Ponciano-Rodriguez G,Chávez-Tapia NC,Motola-Kuba D,Almeda-Valdes P,Sánchez-Lara K,Ramos MH,Uribe M

    更新日期:2005-04-01 00:00:00

  • Sigmoid afferent mechanisms in patients with irritable bowel syndrome.

    abstract::Up to 60% of patients with IBS have lowered perception thresholds in the rectum to balloon distension. The current study sought to test the hypothesis that IBS patients with normal perception thresholds in the rectum show hypersensitivity of afferent pathways in the sigmoid colon. Eleven healthy normal subjects and ei...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1018817132213

    authors: Lembo T,Munakata J,Naliboff B,Fullerton S,Mayer EA

    更新日期:1997-06-01 00:00:00

  • Risk factors for small bowel cancer in Crohn's disease.

    abstract::Suspected risk factors for adenocarcinoma of the small bowel in Crohn's disease include surgically excluded small bowel loops, chronic fistulous disease, and male sex. Review of all seven University of Chicago cases failed to confirm any suspected risk factor. A case-control study was performed to identify possible al...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01296557

    authors: Lashner BA

    更新日期:1992-08-01 00:00:00

  • Serum levels of high-sensitivity C-reactive protein (hs-CRP)in Helicobacter pylori-infected peptic ulcer patients and its association with bacterial CagA virulence factor.

    abstract:OBJECTIVE:CRP is a marker of inflammation and infection of the gastric mucosa with Helicobacter pylori, which causes an inflammatory reaction. It has been reported that CagA(+) H. pylori strains induce more severe gastric inflammation and are also associated with higher risks of peptic ulcer and gastric cancer. The pur...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-008-0686-z

    authors: Jafarzadeh A,Hassanshahi GH,Nemati M

    更新日期:2009-12-01 00:00:00

  • Involvement of Transient Receptor Potential Vanilloid Receptor 1, (TRPV1)-Expressing Vagal Nerve in the Inhibitory Effect of Gastric Acidification on Exogenous Motilin-Induced Gastric Phase III Contractions in Suncus murinus.

    abstract:BACKGROUND:Gastric acidification inhibits motilin-induced gastric phase III contractions. However, the underlying mechanism has not been thoroughly investigated. Here, we studied the inhibitory mechanism by gastric acidification on motilin-induced contraction in Suncus murinus (S. murinus). METHODS:We measured interdi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-015-4023-z

    authors: Yoshimura M,Mikami T,Kuroda K,Nishida M,Ito K,Mondal A,Koyama K,Jogahara T,Sakata I,Sakai T

    更新日期:2016-06-01 00:00:00

  • Wireless capsule motility: comparison of the SmartPill GI monitoring system with scintigraphy for measuring whole gut transit.

    abstract:INTRODUCTION:Assessment of whole gut transit, by radio-opaque markers or scintigraphy, is used to evaluate patients with constipation for slow gastrointestinal transit. Wireless capsule motility, using the SmartPill GI monitoring system, samples and transmits intraluminal pH, pressure, and temperature data from a capsu...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-009-0899-9

    authors: Maqbool S,Parkman HP,Friedenberg FK

    更新日期:2009-10-01 00:00:00

  • Are the echogenicities on intraductal ultrasonography really biliary microlithiasis?

    abstract:BACKGROUND:Intraductal ultrasonography (IDUS) is a useful procedure for diagnosing microlithiasis in the bile duct but it is not easy to differentiate between tiny echogenicity and real microlithiasis. We compared the echogenicity seen on IDUS and the findings of bile microscopy (BM) of bile that was collected in the c...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-009-0770-z

    authors: Kim BJ,Kang P,Lee JK,Sinn DH,Lee KH,Lee KT,Rhee JC,Lim JH

    更新日期:2010-03-01 00:00:00

  • Endoscopic treatment of benign biliary strictures using covered self-expandable metal stents (CSEMS).

    abstract:BACKGROUND AND AIMS:Traditional endoscopic management of benign biliary strictures (BBS) consists of placement of one or more plastic stents. Emerging data support the use of covered self-expandable metal stents (CSEMS). We sought to assess outcome of endoscopic temporary placement of CSEMS in patients with BBS. METHO...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-013-2859-7

    authors: Irani S,Baron TH,Akbar A,Lin OS,Gluck M,Gan I,Ross AS,Petersen BT,Topazian M,Kozarek RA

    更新日期:2014-01-01 00:00:00

  • Efficacy of Vonoprazan-Based Triple Therapy for Helicobacter pylori Eradication: A Multicenter Study and a Review of the Literature.

    abstract:BACKGROUND:Eradication therapies for Helicobacter pylori infection are advancing as new acid inhibitory reagents approved. The aim of this study was to assess the efficacy and safety of vonoprazan-based triple treatment. MATERIALS AND METHODS:Triple therapy with vonoprazan and two antibiotics (amoxicillin and clarithr...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,多中心研究,评审

    doi:10.1007/s10620-017-4664-1

    authors: Tanabe H,Ando K,Sato K,Ito T,Goto M,Sato T,Fujinaga A,Kawamoto T,Utsumi T,Yanagawa N,Ichiishi E,Otake T,Kohgo Y,Nomura Y,Ueno N,Sugano H,Kashima S,Moriichi K,Fujiya M,Okumura T

    更新日期:2017-11-01 00:00:00

  • Cyclooxygenase-2 promotes hepatocellular apoptosis by interacting with TNF-α and IL-6 in the pathogenesis of nonalcoholic steatohepatitis in rats.

    abstract:BACKGROUND AND PURPOSE:The underlying mechanisms of nonalcoholic steatohepatitis (NASH) are poorly understood, and little is known about hepatocellular apoptosis in NASH. Cyclooxygenase (COX)-2, the key enzyme in eicosanoid metabolism, is highly expressed in NASH. COX-2 can also regulate the release of mediators of inf...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-013-2823-6

    authors: Cheng Q,Li N,Chen M,Zheng J,Qian Z,Wang X,Huang C,Xu S,Shi G

    更新日期:2013-10-01 00:00:00

  • Evaluation of early atherosclerosis in patients with inflammatory bowel disease.

    abstract:BACKGROUND:Data regarding early atherosclerosis and inflammatory bowel disease are limited and conflicting results are present. AIMS:The purpose of this study was to evaluate serological and sonographical evidence of subclinical vascular involvement in patients with inflammatory bowel disease. METHODS:Thirty-nine pat...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-012-2148-x

    authors: Kayahan H,Sari I,Cullu N,Yuksel F,Demir S,Akarsu M,Goktay Y,Unsal B,Akpinar H

    更新日期:2012-08-01 00:00:00

  • Immunopathology on hepatocyte expression of HBV surface, core, and x antigens in chronic hepatitis B: clinical and virological correlation.

    abstract:PURPOSE:Hepatocyte expression of HBV surface, core, and x antigens (HBsAg, HBcAg and HBxAg), semi-quantitated by immunopathology, were correlated with clinical and virological data in 80 patients with chronic hepatitis B. RESULTS:Seventy patients were HBsAg positive in cytoplasm, 61 were HBcAg positive, including 45 i...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-009-0895-0

    authors: Chu CM,Shyu WC,Liaw YF

    更新日期:2010-02-01 00:00:00

  • In vitro growth responses of bifidobacteria and enteropathogens to bovine and human lactoferrin.

    abstract::A series of in vitro experiments was performed to test the ability of bovine and human lactoferrin to influence the growth of the gram-positive probiotic bacteria, Bifidobacterium bifidum, Bifidobacterium infantis, and Lactobacillus acidophilus, as well as the gram-negative enteric bacteria, E. coli O157:H7 and Salmon...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1024111310345

    authors: Griffiths EA,Duffy LC,Schanbacher FL,Dryja D,Leavens A,Neiswander RL,Qiao H,DiRienzo D,Ogra P

    更新日期:2003-07-01 00:00:00

  • Endoscopic biopsy is diagnostic in gastric antral vascular ectasia. The "watermelon stomach".

    abstract::Gastric antral vascular ectasia was endoscopically diagnosed in seven patients. Pathologic characteristics of this entity were defined retrospectively, by studying endoscopic pinch biopsy slides from these seven patients and antrectomy specimens from five patients. A scoring system was developed, and the seven patient...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01540274

    authors: Gilliam JH 3rd,Geisinger KR,Wu WC,Weidner N,Richter JE

    更新日期:1989-06-01 00:00:00

  • "Deathgrip" esophagus: segmental aperistalsis following electrical injury.

    abstract::We report a case of documented transient segmental aperistalsis of the distal esophagus following an accidental electrical injury. There are no other reports in the literature demonstrating this phenomenon. A review of gastrointestinal injury secondary to electrical injury is presented. ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1018834609306

    authors: Rubin BM,Doman DB,Goldberg HJ,Golding MI

    更新日期:1998-09-01 00:00:00

  • Anomalous plasma cyclic AMP responses to glucagon in patients with liver disease.

    abstract::The purpose of the present study is to show anomalies of the plasma cAMP response of patients with hepatic disorders to a single injection of a low dose of glucagon (1 microgram/kg body wt). The response was markedly blunted in patients with liver cirrhosis and potentiated in patients with acute or chronic hepatitis. ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01308330

    authors: Maekubo H,Matsushima T,Okada F,Honma M,Ui M

    更新日期:1980-09-01 00:00:00

  • Effect of bile and pancreatic juice on adenoviral-mediated gene delivery: implications on the feasibility of gene delivery through ERCP.

    abstract::Current research in gene delivery to the liver is focused on the intravenous, intraarterial, intraportal, or intratumoral route. Another possible route for gene delivery is via the common bile duct through endoscopic retrograde cholangiopancreatography (ERCP). Whether bile and pancreatic juice have any effect on gene ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1005431703317

    authors: Xie X,Forsmark CE,Lau JY

    更新日期:2000-02-01 00:00:00

  • Insulin Resistance as a Novel Risk Factor for Post-ERCP Pancreatitis: A Pilot Study.

    abstract:BACKGROUND AND AIMS:The relationship between insulin resistance and post-ERCP pancreatitis (PEP) is not known. We aimed to determine the relation between pre-ERCP insulin resistance and risk of PEP, and to evaluate the relationship of insulin resistance with well-established risk factors for PEP. METHODS:Consecutive p...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-016-4127-0

    authors: Koksal AR,Boga S,Alkim H,Bayram M,Ergun M,Alkim C

    更新日期:2016-08-01 00:00:00

  • APOC3 rs2070666 Is Associated with the Hepatic Steatosis Independently of PNPLA3 rs738409 in Chinese Han Patients with Nonalcoholic Fatty Liver Diseases.

    abstract:BACKGROUND AND AIM:The association between nonalcoholic fatty liver disease (NAFLD) and apolipoprotein C3 gene (APOC3) promoter region single-nucleotide polymorphisms (SNPs) rs2854117 and rs2854116 is controversial. The aim of this study was to investigate the relationship between other polymorphisms of APOC3 and NAFLD...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-016-4120-7

    authors: Zhang RN,Zheng RD,Mi YQ,Zhou D,Shen F,Chen GY,Zhu CY,Pan Q,Fan JG

    更新日期:2016-08-01 00:00:00

  • The role of sonic hedgehog reemergence during gastric cancer.

    abstract::Sonic Hedgehog (Shh) signaling has been extensively studied for its role in developmental biology and cancer biology. The association between Shh and cancer development in general is well established but the functional role of Shh in the development and progression of gastric cancer specifically is largely unknown. Bo...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-010-1252-z

    authors: Martin J,Donnelly JM,Houghton J,Zavros Y

    更新日期:2010-06-01 00:00:00

  • Gallbladder ejection fraction and its relationship to sphincter of Oddi dysfunction.

    abstract::Theoretically, relative distal common bile duct obstruction due to sphincter of Oddi dysfunction may be a cause of poor gallbladder evacuation observed on quantitative cholescintigraphy. In this study, the relationship of sphincter of Oddi dysfunction to the gallbladder ejection fraction by quantitative cholescintigra...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02090199

    authors: Ruffolo TA,Sherman S,Lehman GA,Hawes RH

    更新日期:1994-02-01 00:00:00

  • Association between H. pylori, duodenal mechanosensory thresholds, and small intestinal motility in chronic unexplained dyspepsia.

    abstract::Alterations of small intestinal sensory thresholds and small intestinal dysmotility are associated with functional dyspepsia. Because gastric and duodenal afferents partly project to the same areas, we postulated that patients with functional dyspepsia and H. pylori infection would be characterized by lower duodenal s...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02088548

    authors: Holtmann G,Talley NJ,Goebell H

    更新日期:1996-07-01 00:00:00

  • Liver injuries induced by herbal medicine, syo-saiko-to (xiao-chai-hu-tang).

    abstract::Four patients treated with the herbal medicine syo-saiko-to (xiao-chai-hu-tang) exhibited acute drug-induced liver injury. The latent period was one and a half to three months. All of the patients showed a rise in aminotransferases after readministration or challenge test. The liver histology revealed centrilobular co...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02212712

    authors: Itoh S,Marutani K,Nishijima T,Matsuo S,Itabashi M

    更新日期:1995-08-01 00:00:00

  • Randomized, double-blind, placebo-controlled trial of eight-week course of recombinant alpha-interferon for chronic non-A, non-B hepatitis.

    abstract::Forty-nine Japanese patients were enrolled in a randomized, placebo-controlled, double-blind trial of alpha-interferon for chronic non-A, non-B hepatitis: 24 patients received 3 million units of recombinant human alpha alpha-interferon (alpha-2a) thrice weekly for eight weeks, and 25 patients received placebo in a sim...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF01307512

    authors: Omata M,Ito Y,Yokosuka O,Imazeki F,Tagawa M,Takano S,Hosoda K,Tada M,Ohto M,Ito K

    更新日期:1991-09-01 00:00:00

  • A Pilot Program Integrating Hepatitis B Virus (HBV) Screening into an Outpatient Endoscopy Unit Improves HBV Screening Among an Ethnically Diverse Safety-Net Hospital.

    abstract:BACKGROUND:Safety-net hospitals are enriched in ethnic minorities and provide opportunities for high-impact hepatitis B virus (HBV) screening. AIM:We aim to evaluate the impact of a pilot program integrating HBV screening into outpatient endoscopy among urban safety-net populations. METHODS:From July 2015 to May 2017...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-017-4870-x

    authors: Campbell B,Lopez A,Liu B,Bhuket T,Wong RJ

    更新日期:2018-01-01 00:00:00

  • New type of artificial liver support system (ALSS) using the photocatalytic effect of titanium oxide.

    abstract::Although various types of artificial liver support systems (ALSSs) including a hybrid type have been made, few are practical ALSSs for treatment of acute and/or chronic hepatic failure. Titanium oxide (TiO(2)), a stable material, dismantles various materials using a photocatalytic action under ultraviolet irradiation....

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-006-9701-4

    authors: Shinohara H,Shimada M,Ikemoto T,Morine Y,Imura S,Fujii M,Imaizumi T,Murayama M,Aiba Y

    更新日期:2007-09-01 00:00:00

  • Graded esophageal balloon distention. A new provocative test for noncardiac chest pain.

    abstract::The evaluation of suspected esophageal chest pain is frustrating because of difficulty in clearly implicating the esophagus. Balloon distention was considered as a new provocative test in the esophagus because it has been shown to safely produce pain in other hollow gastrointestinal organs. Studies were performed in 5...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01299805

    authors: Barish CF,Castell DO,Richter JE

    更新日期:1986-12-01 00:00:00

  • Improving All-Cause Inpatient Mortality After Percutaneous Endoscopic Gastrostomy.

    abstract:BACKGROUND AND AIMS:Percutaneous gastrostomy (PEG) is a common inpatient procedure. Prior data from National Inpatient Sample (NIS) in 2006 reported a mortality rate of 10.8% and recommended more careful selection of PEG candidates. This study assessed for improvement in the last 10 years in mortality rate and complica...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-020-06396-y

    authors: Stein DJ,Moore MB,Hoffman G,Feuerstein JD

    更新日期:2020-06-19 00:00:00

  • Does the intraesophageal pH probe accurately detect acid reflux? Simultaneous recording with two pH probes in humans.

    abstract::Little is known about the accuracy of intraesophageal pH monitoring, ie, do false negatives occur? This study was designed based on the assumption that if two pH probes are placed equidistant from a distal acid source, and the probes measure different values, then one probe might miss acid if it were there alone. We p...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01540333

    authors: Murphy DW,Yuan Y,Castell DO

    更新日期:1989-05-01 00:00:00