Anti-metastatic efficacy and safety of MMI-166, a selective matrix metalloproteinase inhibitor.

abstract：:Platelet-derived growth factor BB (PDGF BB) and the PDGF receptor beta are expressed on mesothelioma cells, but their biological function has not yet been defined. In the present study we used Boyden chambers fitted with filters coated with the adhesive matrix proteins fibronectin, laminin, collagen type IV or the non...

journal_title：Clinical & experimental metastasis

authors： Klominek J,Baskin B,Hauzenberger D

更新日期：1998-08-01 00:00:00

abstract：:Primary brain tumors lack the metastatic behavior that is in part believed to be promoted by the extracellular matrix (ECM) components of the basement membrane. This study was intended to examine the influence of the ECM components present in the basement membrane that may act as natural barriers to tumor cell invasio...

journal_title：Clinical & experimental metastasis

authors： Chintala SK,Gokaslan ZL,Go Y,Sawaya R,Nicolson GL,Rao JS

更新日期：1996-09-01 00:00:00

abstract：:Mouse mammary carcinoma cells were exposed in vitro to increasing concentrations of doxorubicin hydrochloride [adriamycin (ADR)] or 5-fluorouracil (5-FU). Uptake of [75Se]selenomethionine (75SeM) in a methionine-deficient medium measured the resulting inhibition of protein synthesis by the tumour cells. This was compa...

journal_title：Clinical & experimental metastasis

authors： Lai T,Stonebridge BR,Black J,Symes MO

更新日期：1989-07-01 00:00:00

abstract：:Vascularization of solid tumors is thought to occur by sprouting or intussusceptive angiogenesis, co-option of existing vessels, and vasculogenic mimicry after the onset of tumor hypoxia, when the tumor radius exceeds the oxygen diffusion distance. In contrast, here we show that individual endothelial cells that are i...

journal_title：Clinical & experimental metastasis

authors： Elzarrad K,Haroon A,Reed D,Al-Mehdi AB

更新日期：2009-01-01 00:00:00

abstract：:Brain metastases are the most common intracranial tumors in adults, accounting for more than 50% of all such cases. The approach to and management of brain metastases have evolved significantly in recent years due to several reasons. These include advances in neurosurgical and radiotherapeutic techniques, improved sys...

journal_title：Clinical & experimental metastasis

authors： Thiagarajan A,Yamada Y

更新日期：2017-10-01 00:00:00

abstract：:To study the tumor cell autonomous processes of metastasis, an in vivo tumor metastasis model is required that excludes the involvement of the innate immune system. For this purpose we used the established syngeneic MTLn3 cell - Fischer 344 tumor model. MTLn3 cells are efficiently eradicated by NK cells in vivo. Using...

journal_title：Clinical & experimental metastasis

authors： van Nimwegen MJ,Verkoeijen S,Kuppen PJ,Velthuis JH,van de Water B

更新日期：2007-01-01 00:00:00

abstract：:To aid in therapy selection for patients with spinal bone metastases (SBM), predictive models have been developed. These models consider SBM from breast cancer a positive predictive factor, but do not take phenotypes based on estrogen (ER), progesterone (PR) and human epidermal growth factor 2 (HER2) receptors into ac...

journal_title：Clinical & experimental metastasis

authors： Bollen L,Wibmer C,Wang M,van der Linden YM,Leithner A,Bünger CE,Jensen AB,Fiocco M,Bratschitsch G,Pondaag W,Bovée JV,Dijkstra PD

更新日期：2015-01-01 00:00:00

abstract：:Although the loss of sulfomucins was known as an indicator of carcinogenesis and malignant progression of colonic epithelia, it was not known whether the loss was directly related to the malignant behavior of colon carcinoma cells. We have studied the biological properties of LS174T human colon carcinoma cells before ...

journal_title：Clinical & experimental metastasis

authors： Tsuiji H,Nakatsugawa S,Ishigaki T,Irimura T

更新日期：1999-03-01 00:00:00

abstract：:The abilities of tumor cells to extravasate from the blood vessel system and to migrate through the connective tissue are prerequisites in metastasis formation. Both processes are chiefly mediated by integrins, which mediate both cell-cell and cell-matrix interactions. We investigated the role of integrin subunits in ...

journal_title：Clinical & experimental metastasis

authors： Heyder C,Gloria-Maercker E,Hatzmann W,Niggemann B,Zänker KS,Dittmar T

更新日期：2005-01-01 00:00:00

abstract：:Very few tissues in vivo are resistant to invasion by malignant cells. In this paper, confrontation cultures consisting of chick embryonic notochord fragments and cell aggregates from three malignant neurogenic cell lines showed a resistance of the embryonic organ to malignant invasion by tumor cells. The mechanism of...

journal_title：Clinical & experimental metastasis

authors： Schroyens W,Camon J,De Ridder L

更新日期：1991-07-01 00:00:00

abstract：:Osteopontin (OPN) is a glycosylated, secreted phosphoprotein that functions both as a cell attachment and chemotactic factor. Elevated expression of OPN confers enhanced metastatic ability on transformed cells, suggesting that OPN may contribute to the malignant progression of tumors. Migration of mammary carcinoma ce...

journal_title：Clinical & experimental metastasis

authors： Khan SA,Cook AC,Kappil M,Günthert U,Chambers AF,Tuck AB,Denhardt DT

更新日期：2005-01-01 00:00:00

abstract：:Metastatic castrate resistant prostate cancer (mCRPC) is responsible for the majority of prostate cancer deaths with the median survival after diagnosis being 2 years. The metastatic lesions often arise in the skeleton, and current treatment options are primarily palliative. Using guidelines set forth by the National ...

journal_title：Clinical & experimental metastasis

authors： Gallaher J,Cook LM,Gupta S,Araujo A,Dhillon J,Park JY,Scott JG,Pow-Sang J,Basanta D,Lynch CC

更新日期：2014-12-01 00:00:00

abstract：:We have previously reported that induction of MMP-2 activation by Concanavalin A (ConA) in MDA-MB-231 human breast cancer cells involves both transcriptional and post-transcriptional mechanisms, and that the continuous presence of ConA is required for MMP-2 activation (Yu et al. Cancer Res, 55, 3272-7, 1995). In an ef...

journal_title：Clinical & experimental metastasis

authors： Yu M,Sato H,Seiki M,Spiegel S,Thompson EW

更新日期：1998-02-01 00:00:00

abstract：:This study compared phenotype and behaviour of seven head and neck squamous cell carcinoma (HNSCC) cell lines and normal epithelial cells. Indications were found that in HNSCC cells: 1) loss of the cell-cell adhesion molecule E-cadherin was correlated with loss of epithelioid cell morphology but not with loss of cell-...

journal_title：Clinical & experimental metastasis

authors： Tomson AM,Scholma J,Meijer B,Koning JG,de Jong KM,van der Werf M

更新日期：1996-11-01 00:00:00

abstract：:The effect of thioglycollate-elicited macrophages (TG-M phi) on natural killer (NK)-cell activity and metastases formation in mice was investigated. Intravenously (i.v.) inoculated TG-M phi inhibited spleen NK activity of normal mice and abrogated polyinosinic: polycytidylic (poly I:C) induced augmentation of NK cell ...

journal_title：Clinical & experimental metastasis

authors： Gorelik E,Wiltrout RH,Brunda MJ,Bere WE,Herberman RB

更新日期：1985-04-01 00:00:00

abstract：:Recently the concept that gap junctions play a role in cancer cell metastasis has emerged. However, the mechanism by which this might occur is unknown. To examine this issue a metastatic breast cancer cell line, MDA-MB-435, was stably transfected with human Cx43 cDNA. Four clones of 435 transfectants (435/Cx43(+) c1, ...

journal_title：Clinical & experimental metastasis

authors： Li Z,Zhou Z,Welch DR,Donahue HJ

更新日期：2008-01-01 00:00:00

abstract：:A number of papers have been published on the clinical correlation of the expression of the 67 kDa laminin binding protein (LBP) with the metastatic potential of solid tumors. Both mRNA and protein expression levels have been reported, but both the relationship between them and the molecular nature of the 67 kDa surfa...

journal_title：Clinical & experimental metastasis

authors： Landowski TH,Uthayakumar S,Starkey JR

更新日期：1995-09-01 00:00:00

abstract：:Development of central nervous system (CNS) metastases in breast cancer (BC) is associated with poor prognosis. The incidence of CNS metastases in metastatic BC is reported to be about 10-16 %, but different subtypes of BC are associated with different risk of developing CNS metastases. We retrospectively analysed the...

journal_title：Clinical & experimental metastasis

authors： Minisini AM,Moroso S,Gerratana L,Giangreco M,Iacono D,Poletto E,Guardascione M,Fontanella C,Fasola G,Puglisi F

更新日期：2013-12-01 00:00:00

abstract：:The concurrent administration of Metrazol (60 mg/kg, i.v.) to anaesthetized rats enhances the cerebral penetration of the anticancer agent razoxane. Such an enhancement leads to an increase in the therapeutic efficacy of razoxane against intracerebrally sequestered L1210 leukaemia cells in mice. The combination of Met...

journal_title：Clinical & experimental metastasis

authors： Greig N,Newell D,Hellmann K

更新日期：1984-01-01 00:00:00

abstract：:MUC1 is a transmembrane glycoprotein expressed by normal breast epithelium and virtually all breast cancers. MUC1 is normally restricted to the apical surface of epithelia and loss of this polarized distribution in breast carcinomas is associated with lymph node metastasis. Our previous work found that MUC1 can bind i...

journal_title：Clinical & experimental metastasis

authors： Rahn JJ,Chow JW,Horne GJ,Mah BK,Emerman JT,Hoffman P,Hugh JC

更新日期：2005-01-01 00:00:00

abstract：:Melanoma is an aggressive cutaneous malignancy with rapidly rising incidence. Diagnosis of controversial melanocytic lesions, correct prognostication of patients, selection of appropriate adjuvant and systemic therapies, and prediction of response to a given therapy remain very real challenges. Despite these challenge...

journal_title：Clinical & experimental metastasis

authors： Ankeny JS,Labadie B,Luke J,Hsueh E,Messina J,Zager JS

更新日期：2018-08-01 00:00:00

abstract：:Single cell progenies (SCPs) inherit biological properties from their isogenetic mother cells. If a single cancer cell can give rise to progenies, which can be passaged sustainably in vitro and produce tumor in xenotransplantation, the cell should be cancer initiating cell. CD133 (Prominin-1, Prom1) is the marker of h...

journal_title：Clinical & experimental metastasis

authors： Li G,Liu C,Yuan J,Xiao X,Tang N,Hao J,Wang H,Bian X,Deng Y,Ding Y

更新日期：2010-10-01 00:00:00

abstract：:Recent studies have indicated that KHT fibrosarcoma or B16 melanoma cell variants capable of forming experimental metastases in the lungs of mice after i.v. injection are created stochastically at high rates (approximately 10(-5)/cell/generation). Expression of this phenotype is unstable and hence expanding population...

journal_title：Clinical & experimental metastasis

authors： Young SD,Hill RP

更新日期：1986-07-01 00:00:00

abstract：:A new model for the study of spontaneous bone metastasis has been developed which allows for the quantification of metastatic tumor burden and cancer cell growth rate, and which describes the progressive changes in bone morphology. Walker 256 (W256) cells or vehicle were injected into the left upper thigh muscle of ma...

journal_title：Clinical & experimental metastasis

authors： Kostenuik PJ,Singh G,Suyama KL,Orr FW

更新日期：1992-11-01 00:00:00

abstract：:Human tissue factor pathway inhibitor-2 (TFPI-2), also known as placental protein (PP5) and matrix-associated serine protease inhibitor (MSPI), is a 32-kDa extracellular matrix (ECM) protein consisting of three tandomly arranged Kunitz-type domains that inhibits plasmin, trypsin, chymotrypsin, cathepsin G and plasma k...

journal_title：Clinical & experimental metastasis

authors： Konduri SD,Tasiou A,Chandrasekar N,Nicolson GL,Rao JS

更新日期：2000-01-01 00:00:00

abstract：:Integrins expressed on endothelial cells modulate cell migration and survival during angiogenesis. Integrins expressed on carcinoma cells potentiate metastasis by facilitating invasion and movement across blood vessels. We describe the activities of two synthetic low-molecular-weight peptidomimetics of the ligand amin...

journal_title：Clinical & experimental metastasis

authors： Shannon KE,Keene JL,Settle SL,Duffin TD,Nickols MA,Westlin M,Schroeter S,Ruminski PG,Griggs DW

更新日期：2004-01-01 00:00:00

abstract：:Brain metastases present a significant public health issue, affecting more than 100,000 patients per year in the U.S. and result in significant morbidity. Brain metastases can occur in a variety of clinical situations ranging from multiple brain metastases with uncontrolled systemic disease to a solitary metastasis in...

journal_title：Clinical & experimental metastasis

authors： Ferguson SD,Wagner KM,Prabhu SS,McAleer MF,McCutcheon IE,Sawaya R

更新日期：2017-10-01 00:00:00

abstract：:MACC1 (metastasis associated in colon cancer 1) is a key driver that induces metastasis in colon cancer. However, the mechanisms by which MACC1 expression is transcriptionally regulated and the factors enriched at the MACC1 promoter remain largely unknown. The binding of proteins to specific DNA sites in the genome is...

journal_title：Clinical & experimental metastasis

authors： Huang Y,Xiang Y,Xie Z,Cai Y,Yang Q,Huang H,Chen Z,Xiao Z,He Q

更新日期：2020-08-01 00:00:00

abstract：:Cancer stem cells drive the metastatic cascade by undergoing epithelial to mesenchymal transition (EMT) and again mesenchymal to epithelial transition (MET). Using multiple breast cancer cell lines including cigarette smoke induced breast cancer cells and tumor derived primary cells from patient sample; we developed a...

journal_title：Clinical & experimental metastasis

authors： Siddharth S,Das S,Nayak A,Kundu CN

更新日期：2016-10-01 00:00:00

abstract：:Inflammatory breast cancer (IBC) is the most lethal form of locally advanced breast cancer known. IBC carries a guarded prognosis primarily due to rapid onset of disease, typically within six months, and the propensity of tumor emboli to invade the dermal lymphatics and spread systemically. Although the clinical manif...

journal_title：Clinical & experimental metastasis

authors： van Golen KL,Bao LW,Pan Q,Miller FR,Wu ZF,Merajver SD

更新日期：2002-01-01 00:00:00