Role of tissue factor pathway inhibitor-2 (TFPI-2) in amelanotic melanoma (C-32) invasion.

abstract：:p38 belongs to a family of mitogen-activated protein kinases, which transfer extracellular signals into intracellular responses. p38 is also frequently detected in clinical breast cancer specimens, but its role as a prognostic factor is not known. Of the various p38 isoforms, p38alpha has been shown to mediate the in ...

journal_title：Clinical & experimental metastasis

authors： Suarez-Cuervo C,Merrell MA,Watson L,Harris KW,Rosenthal EL,Väänänen HK,Selander KS

更新日期：2004-01-01 00:00:00

abstract：:Cancer metastasis shows great diversity in target organs, routes and molecular mechanisms depending on the type of cancer and even on the individual patients. To identify key molecules involved in metastasis, we constructed a murine model system including multiple sublines with different organotropism and pathways of ...

journal_title：Clinical & experimental metastasis

authors： Sugino T,Ichikawa-Tomikawa N,Tanaka M,Shishito N,Miura T,Abe M,Muramatsu K,Oishi T,Kakuda Y,Kawata T,Akiyama Y

更新日期：2019-08-01 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is one of few cancers with rising incidence in North America. The prognosis of ccRCC is variable and difficult to predict. Stratification of patients according to disease aggressiveness can significantly improve patient management. We investigated the expression of the S100A11 p...

journal_title：Clinical & experimental metastasis

authors： Gabril M,Girgis H,Scorilas A,Rotondo F,Wala S,Bjarnason GA,Ding Q,Evans A,Tawedrous E,Pasic M,Finelli A,Al-Haddad S,Yousef GM

更新日期：2016-01-01 00:00:00

abstract：:Breast cancer metastasizes to bone with high frequency and incidence. However, studies of breast cancer metastasis to bone have been limited by two factors. First, the number of models that colonize bone are limited. Second, detection of bone metastases is too insensitive or too laborious for routine, large-scale stud...

journal_title：Clinical & experimental metastasis

authors： Harms JF,Welch DR

更新日期：2003-01-01 00:00:00

abstract：:Metastatic bone disease is an important clinical problem which has proven difficult to study because of a lack of noninvasive investigative modalities. Here we show that dual-energy X-ray absorptiometry (DXA) scanning provides clinically useful information about the status of metastatic bone lesions in cancer patients...

journal_title：Clinical & experimental metastasis

authors： Smith GL,Doherty AP,Banks LM,Dutton J,Hanham LW,Christmas TJ,Epstein RJ

更新日期：2000-01-01 00:00:00

abstract：:We applied reverse phase protein microarrays technology to map signal pathway interactions in a discovery set of 34 soft tissue sarcoma (STS) bone metastases compared to healthy bone. Proteins associated with matrix remodeling (MMP), adhesion (FAK Y576/577, Syndecan-1), and growth/survival (IGF1R Y1135/1136, PI3K, EGF...

journal_title：Clinical & experimental metastasis

authors： Conti A,Espina V,Chiechi A,Magagnoli G,Novello C,Pazzaglia L,Quattrini I,Picci P,Liotta LA,Benassi MS

更新日期：2014-01-01 00:00:00

abstract：:Development of central nervous system (CNS) metastases in breast cancer (BC) is associated with poor prognosis. The incidence of CNS metastases in metastatic BC is reported to be about 10-16 %, but different subtypes of BC are associated with different risk of developing CNS metastases. We retrospectively analysed the...

journal_title：Clinical & experimental metastasis

authors： Minisini AM,Moroso S,Gerratana L,Giangreco M,Iacono D,Poletto E,Guardascione M,Fontanella C,Fasola G,Puglisi F

更新日期：2013-12-01 00:00:00

abstract：:Previous studies from our laboratory have demonstrated that metastatic propensity is significantly influenced by the genetic background upon which tumors arise. We have also established that human gene expression profiles predictive of metastasis are not only present in mouse tumors with both high and low metastatic c...

journal_title：Clinical & experimental metastasis

authors： Yang H,Crawford N,Lukes L,Finney R,Lancaster M,Hunter KW

更新日期：2005-01-01 00:00:00

abstract：:We previously isolated thymosin beta15 from highly metastatic Dunning rat prostatic carcinoma cells. Immunohistochemical study of human prostate cancer specimens revealed a general correlation between Gleason grade and thymosin beta15 expression, with high-grade (more malignant) tumors showing increased staining compa...

journal_title：Clinical & experimental metastasis

authors： Bao L,Loda M,Zetter BR

更新日期：1998-04-01 00:00:00

abstract：:Hypermethylation of the promoter region of tumor suppressor genes is associated with carcinogenesis in lung cancer (LC). Endobronchial ultrasound with needle aspiration (EBUS-NA) is a semi-invasive method for obtaining cell blocks from lymph nodes, which can be used for epigenetic analyses. To establish the relationsh...

journal_title：Clinical & experimental metastasis

authors： Millares L,Serra M,Andreo F,Sanz-Santos J,Montón C,Grimau C,Gallego M,Setó L,Combalia N,Llatjos M,Escoda R,Castellà E,Monsó E

更新日期：2015-10-01 00:00:00

abstract：:Cancer cells selected from a cultured murine fibrosarcoma by rapid migration through micropore membranes moved considerably faster through such membranes and invaded biological tissues much more efficiently than did the unselected parent cells. The present data show that populations of cells selected by unstimulated m...

journal_title：Clinical & experimental metastasis

authors： Grimstad IA

更新日期：1988-07-01 00:00:00

abstract：:Primary tumor growth and metastasis depend on angiogenesis, which is determined by the balance between proangiogenic and antiangiogenic molecules. Interferon (IFN)-alpha and -beta inhibit angiogenesis through downregulation of interleukin-8, matrix metalloproteinase-9, and basic fibroblast growth factor. To provide ev...

journal_title：Clinical & experimental metastasis

authors： McCarty MF,Bielenberg D,Donawho C,Bucana CD,Fidler IJ

更新日期：2002-01-01 00:00:00

abstract：:GPR56, a non-classical adhesion receptor, was previously reported to suppress tumor growth and metastasis in xenograft models using human melanoma cell lines. To understand whether GPR56 plays similar roles in the development of endogenous tumors, we analyzed cancer progression in Gpr56 (-/-) mice using a variety of t...

journal_title：Clinical & experimental metastasis

authors： Xu L,Begum S,Barry M,Crowley D,Yang L,Bronson RT,Hynes RO

更新日期：2010-04-01 00:00:00

abstract：:We recently developed a method for the isolation and purification of tumour-derived endothelium. In this study the phenotypic and functional properties of human tumour-derived microvascular endothelial cells (TdMEC) were examined. Endothelium obtained from human adrenal gland specimens (HAMEC) was used as a reference ...

journal_title：Clinical & experimental metastasis

authors： Alessandri G,Chirivi RG,Fiorentini S,Dossi R,Bonardelli S,Giulini SM,Zanetta G,Landoni F,Graziotti PP,Turano A,Caruso A,Zardi L,Giavazzi R,Bani MR

更新日期：1999-01-01 00:00:00

abstract：:An overview of colorectal cancer discussed (Philip Paty) the good outcome after primary management with local control in 90-95 % of colon and 85 % in rectal cancer patients with major progression to metastases and to death related to hematogenous dissemination. The major disease pathways include the APC, aneuploid pat...

journal_title：Clinical & experimental metastasis

authors： Wanebo HJ,LeGolvan M,Paty PB,Saha S,Zuber M,D'Angelica MI,Kemeny NE

更新日期：2012-10-01 00:00:00

abstract：:To evaluate the local control (LC), progression free survival (PFS), out-field PFS, overall survival (OS), toxicity and failure predictors of SRT in a series of various sites oligometastatic CRC patients. Patients with oligometastatic CRC disease were analyzed retrospectively. The SRT prescribed dose was dependent on ...

journal_title：Clinical & experimental metastasis

authors： Dell'Acqua V,Surgo A,Kraja F,Kobiela J,Zerella MA,Spychalski P,Gandini S,Francia CM,Ciardo D,Fodor C,Ferrari AM,Piperno G,Cattani F,Vigorito S,Pansini F,Petz W,Orecchia R,Leonardi MC,Jereczek-Fossa BA

更新日期：2019-08-01 00:00:00

abstract：:To evaluate the relationship between the c-kit proto-oncogene product and malignant transformation of human breast tissue, we examined the immunohistochemical expression of the c-kit proto-oncogene product in both malignant and non-malignant breast tissues. The immunohistochemical expression of the c-kit proto-oncogen...

journal_title：Clinical & experimental metastasis

authors： Ko CD,Kim JS,Ko BG,Son BH,Kang HJ,Yoon HS,Cho EY,Gong G,Ahn SH

更新日期：2003-01-01 00:00:00

abstract：:Metastatic castrate resistant prostate cancer (mCRPC) is responsible for the majority of prostate cancer deaths with the median survival after diagnosis being 2 years. The metastatic lesions often arise in the skeleton, and current treatment options are primarily palliative. Using guidelines set forth by the National ...

journal_title：Clinical & experimental metastasis

authors： Gallaher J,Cook LM,Gupta S,Araujo A,Dhillon J,Park JY,Scott JG,Pow-Sang J,Basanta D,Lynch CC

更新日期：2014-12-01 00:00:00

abstract：:A murine mammary carcinoma, which had a high potential for metastasis to the lungs, was established in culture, and from the parent line several clonally derived variants were isolated, showing different characteristics including metastatic potential. C1, a high metastatic clone, and C2, a low one, were selected for f...

journal_title：Clinical & experimental metastasis

authors： Lee AE,Rogers LA,Jeffery RE,Longcroft JM

更新日期：1988-11-01 00:00:00

abstract：:NIH3T3 cells transfected with an activated Ha-ras oncogene were treated with L-PHA, the leukoagglutinin from red kidney beans. Cell lines resistant to L-PHA-mediated cytotoxicity were isolated and found to contain reduced levels of L-PHA-binding oligosaccharides. The levels of N-acetylglucosaminyltransferase V, the en...

journal_title：Clinical & experimental metastasis

authors： Lu Y,Pelling JC,Chaney WG

更新日期：1994-01-01 00:00:00

abstract：:Metastasis, responsible for most deaths from breast cancer (BC), is a multistep process leading to cancer cell spread. Extracellular matrix (ECM)-related adhesion and apoptosis resistance play pivotal role in metastasis. Ras suppressor-1 (RSU-1) localizes to cell-ECM adhesions and binds to pro-survival adhesion protei...

journal_title：Clinical & experimental metastasis

authors： Giotopoulou N,Valiakou V,Papanikolaou V,Dubos S,Athanassiou E,Tsezou A,Zacharia LC,Gkretsi V

更新日期：2015-03-01 00:00:00

abstract：:Prostate cancer metastases form selectively in the bone marrow. Previously we demonstrated motility was important for the formation of primary prostatic epithelial cell colonies in bone marrow stroma (BMS) co-culture. In this study we looked at the influence of motility factors on the colony formation of epithelial ce...

journal_title：Clinical & experimental metastasis

authors： Lang SH,Clarke NW,George NJ,Testa NG

更新日期：1999-06-01 00:00:00

abstract：:Breast cancer dissemination can be monitored in patients by detecting circulating and/or disseminated tumor cells. However, bone marrow disseminated tumor cells (BM DTC) may undergo a dormancy during several years before growing (or not) into clinically detectable metastases. We therefore hypothesized that breast canc...

journal_title：Clinical & experimental metastasis

authors： Bidard FC,Vincent-Salomon A,Sigal-Zafrani B,Rodrigues M,Diéras V,Mignot L,Sastre-Garau X,Poupon MF,Pierga JY

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Metastasis to bone from endometrial adenocarcinoma is rare, when metastasises it usually locates in axial skeleton. Metastasis to extremities is extremely rare. Additionally the detection of the bone metastasis as a presenting feature is uncommon. In the present study we report the 10th cases of bone metasta...

journal_title：Clinical & experimental metastasis

authors： Kaya A,Olmezoglu A,Eren CS,Bayol U,Altay T,Karapinar L,Ozturk H,Oztekin D,Guvenli Y,Karadogan I

更新日期：2007-01-01 00:00:00

abstract：:Recombinant murine interferon beta (MuIFN-beta) given i.v. efficiently inhibited both pulmonary arrest and formation of lung colonies of NL-17, a highly metastatic variant of mouse colon adenocarcinoma 26. NL-17 was rather resistant to MuIFN-beta in vitro and was highly resistant to natural killer cells of mice even t...

journal_title：Clinical & experimental metastasis

authors： Tsuruo T,Saito H,Watanabe M,Sugimoto Y,Yamori T,Oh-Hara T

更新日期：1990-03-01 00:00:00

abstract：:Matrilysin is a member of the matrix metalloproteinase gene family which is believed to play an important role in tumor progression. Expression of matrilysin mRNA was examined by reverse transcription-polymerase chain reaction combined with Southern blot analysis in 46 human primary gastric cancers. Overexpression of ...

journal_title：Clinical & experimental metastasis

authors： Senota A,Itoh F,Yamamoto H,Adachi Y,Hinoda Y,Imai K

更新日期：1998-05-01 00:00:00

abstract：:MicroRNAs have been identified as key players in the development and progression of osteosarcoma, which is the most common primary malignancy of bone. Sequencing-based miR-omic and quantitative real-time PCR analyses suggested that the expression of miR-193a-3p and miR-193a-5p was decreased by DNA methylation at their...

journal_title：Clinical & experimental metastasis

authors： Pu Y,Zhao F,Cai W,Meng X,Li Y,Cai S

更新日期：2016-04-01 00:00:00

abstract：:Spatial and temporal oxygen heterogeneity exists in most solid tumour microenvironments due to an inadequate vascular network supplying a dense population of tumour cells. An imbalance between oxygen supply and demand leads to hypoxia within a significant proportion of a tumour, which has been correlated to the likeli...

journal_title：Clinical & experimental metastasis

authors： Subarsky P,Hill RP

更新日期：2008-01-01 00:00:00

abstract：:Recent studies have indicated that KHT fibrosarcoma or B16 melanoma cell variants capable of forming experimental metastases in the lungs of mice after i.v. injection are created stochastically at high rates (approximately 10(-5)/cell/generation). Expression of this phenotype is unstable and hence expanding population...

journal_title：Clinical & experimental metastasis

authors： Young SD,Hill RP

更新日期：1986-07-01 00:00:00

abstract：:ECA109 human oesophageal carcinoma cells were injected either subcutaneously or intraperitoneally into BALB/CATc 1-nu/nu mice. After 23 weeks tumours were examined histologically and by scanning electron microscopy. Subcutaneous ECA109 tumours were well-delineated without signs of invasion. By contrast, intra-abdomina...

journal_title：Clinical & experimental metastasis

authors： Gao J,Xue KX,Li BG,Dong HY,Wei LS,Zhang ZH,Tian S,Xu ZG

更新日期：1984-07-01 00:00:00