Abstract:
:Brain metastases present a significant public health issue, affecting more than 100,000 patients per year in the U.S. and result in significant morbidity. Brain metastases can occur in a variety of clinical situations ranging from multiple brain metastases with uncontrolled systemic disease to a solitary metastasis in the setting of controlled systemic disease. Additionally, advances in genomics have broadened the opportunities for targeted treatment options and potentially more durable systemic responses. As such, the treatment of brain metastases is now more tailored and multimodal, involving systemic, radiation, and surgical therapies, often in combination. This review discusses the historical and current role of neurosurgical techniques in the treatment of brain metastases.
journal_name
Clin Exp Metastasisjournal_title
Clinical & experimental metastasisauthors
Ferguson SD,Wagner KM,Prabhu SS,McAleer MF,McCutcheon IE,Sawaya Rdoi
10.1007/s10585-017-9860-zsubject
Has Abstractpub_date
2017-10-01 00:00:00pages
377-389issue
6-7eissn
0262-0898issn
1573-7276pii
10.1007/s10585-017-9860-zjournal_volume
34pub_type
杂志文章,评审abstract::Previous studies from our laboratory have demonstrated that metastatic propensity is significantly influenced by the genetic background upon which tumors arise. We have also established that human gene expression profiles predictive of metastasis are not only present in mouse tumors with both high and low metastatic c...
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journal_title:Clinical & experimental metastasis
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journal_title:Clinical & experimental metastasis
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journal_title:Clinical & experimental metastasis
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pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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journal_title:Clinical & experimental metastasis
pub_type: 杂志文章
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更新日期:2003-01-01 00:00:00
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journal_title:Clinical & experimental metastasis
pub_type: 杂志文章
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journal_title:Clinical & experimental metastasis
pub_type: 杂志文章
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更新日期:1994-07-01 00:00:00
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journal_title:Clinical & experimental metastasis
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doi:10.1007/s10585-013-9565-x
更新日期:2013-06-01 00:00:00
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journal_title:Clinical & experimental metastasis
pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
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journal_title:Clinical & experimental metastasis
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
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journal_title:Clinical & experimental metastasis
pub_type: 杂志文章
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journal_title:Clinical & experimental metastasis
pub_type: 杂志文章
doi:10.1007/BF00123395
更新日期:1996-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
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journal_title:Clinical & experimental metastasis
pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
abstract::A previous study from our laboratory suggested that prostate cancer metastasis to bone may be mediated, in part, by preferential adhesion to human bone marrow endothelial (HBME) cells. Tumor cell adhesion to endothelial cells may be modulated by the effect of cytokines on cell adhesion molecules (CAMs). Tumor necrosis...
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更新日期:2013-10-01 00:00:00
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journal_title:Clinical & experimental metastasis
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更新日期:2014-12-01 00:00:00
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journal_title:Clinical & experimental metastasis
pub_type: 杂志文章,评审
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journal_title:Clinical & experimental metastasis
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journal_title:Clinical & experimental metastasis
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