Neurosurgical management of brain metastases.


:Brain metastases present a significant public health issue, affecting more than 100,000 patients per year in the U.S. and result in significant morbidity. Brain metastases can occur in a variety of clinical situations ranging from multiple brain metastases with uncontrolled systemic disease to a solitary metastasis in the setting of controlled systemic disease. Additionally, advances in genomics have broadened the opportunities for targeted treatment options and potentially more durable systemic responses. As such, the treatment of brain metastases is now more tailored and multimodal, involving systemic, radiation, and surgical therapies, often in combination. This review discusses the historical and current role of neurosurgical techniques in the treatment of brain metastases.


Clin Exp Metastasis


Ferguson SD,Wagner KM,Prabhu SS,McAleer MF,McCutcheon IE,Sawaya R




Has Abstract


2017-10-01 00:00:00














  • Differential growth and responsiveness to cancer therapy of tumor cells in different environments.

    abstract::Tumor metastasis often confers poor prognosis for cancer patients due to lack of comprehensive strategy in dealing with cells growing in different environment. Current anticancer therapies have incomplete effectiveness because they were designed assuming metastatic tumors behave similarly in different organs. We hypot...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Alsaggar M,Yao Q,Cai H,Liu D

    更新日期:2016-02-01 00:00:00

  • Dendritic cells recruitment in melanoma metastasis treated by electrochemotherapy.

    abstract::Electrochemotherapy (ECT) is a novel treatment for recurrent or in-transit unresectable melanoma metastases based on the administration of anti-neoplastic drugs followed by cancer cell electroporation. Whether ECT can also induce anti-tumour immunity is unclear. We addressed this issue investigating the presence of de...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Gerlini G,Sestini S,Di Gennaro P,Urso C,Pimpinelli N,Borgognoni L

    更新日期:2013-01-01 00:00:00

  • Analysis of c-fos, c-jun, c-erbB1, c-erbB2 and c-myc in primary lung carcinomas and their lymph node metastases.

    abstract::The purpose of this study was to identify possible alterations in proto-oncogenes (c-fos, c-jun, c-erbB1, c-erbB2 and c-myc) at the protein level in primary lung carcinomas and simultaneous metastatic lymph nodes of 21 patients. The analysis showed that proteins of c-jun and c-myc were expressed in a significantly hig...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Volm M,van Kaick G,Mattern J

    更新日期:1994-07-01 00:00:00

  • Estradiol increases ER-negative breast cancer metastasis in an experimental model.

    abstract::Breast cancer (BC) is the most common cancer affecting women in the United States and metastatic breast cancer is the leading cause of death. The role estradiol plays in ER-positive BC is well-documented, but the way it contributes to ER-negative BC remains unclear. In the present study, we utilized an experimental mo...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Yang X,Belosay A,Du M,Fan TM,Turner RT,Iwaniec UT,Helferich WG

    更新日期:2013-08-01 00:00:00

  • Early incorporated endothelial cells as origin of metastatic tumor vasculogenesis.

    abstract::Vascularization of solid tumors is thought to occur by sprouting or intussusceptive angiogenesis, co-option of existing vessels, and vasculogenic mimicry after the onset of tumor hypoxia, when the tumor radius exceeds the oxygen diffusion distance. In contrast, here we show that individual endothelial cells that are i...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Elzarrad K,Haroon A,Reed D,Al-Mehdi AB

    更新日期:2009-01-01 00:00:00

  • Review of diagnostic, prognostic, and predictive biomarkers in melanoma.

    abstract::Melanoma is an aggressive cutaneous malignancy with rapidly rising incidence. Diagnosis of controversial melanocytic lesions, correct prognostication of patients, selection of appropriate adjuvant and systemic therapies, and prediction of response to a given therapy remain very real challenges. Despite these challenge...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章,评审


    authors: Ankeny JS,Labadie B,Luke J,Hsueh E,Messina J,Zager JS

    更新日期:2018-08-01 00:00:00

  • Improving treatment strategies for patients with metastatic castrate resistant prostate cancer through personalized computational modeling.

    abstract::Metastatic castrate resistant prostate cancer (mCRPC) is responsible for the majority of prostate cancer deaths with the median survival after diagnosis being 2 years. The metastatic lesions often arise in the skeleton, and current treatment options are primarily palliative. Using guidelines set forth by the National ...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Gallaher J,Cook LM,Gupta S,Araujo A,Dhillon J,Park JY,Scott JG,Pow-Sang J,Basanta D,Lynch CC

    更新日期:2014-12-01 00:00:00

  • Influence of the host microenvironment on the clonal selection of human colon carcinoma cells during primary tumor growth and metastasis.

    abstract::The purpose of this study was to determine the subpopulation dynamics of human colon carcinoma (HCC) cells growing at orthotopic (cecum, liver) or ectopic (subcutis, kidney, spleen) sites in nude mice and to correlate any outgrowth of distinct clones with the differential expression of metastasis-related genes. Low me...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Singh RK,Tsan R,Radinsky R

    更新日期:1997-03-01 00:00:00

  • Lymphatic metastasis in breast cancer: importance and new insights into cellular and molecular mechanisms.

    abstract::Lymph node metastasis is the main prognosis factor in a number of malignancies, including breast carcinomas. The means by which lymph node metastases arise is not fully understood, and many questions remain about their importance in the further spread of breast cancer. Nevertheless, a number of key cellular and molecu...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章,评审


    authors: Eccles S,Paon L,Sleeman J

    更新日期:2007-01-01 00:00:00

  • A convenient clinically relevant model of human breast cancer bone metastasis.

    abstract::Breast cancer patients with advanced disease exhibit bone metastases, leading to the formation of osteolytic lesions for which the only currently available treatments are palliative. Here, we describe how we refined a mouse model of human breast cancer metastasis into bone, characterized its transcriptome and demonstr...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Garcia T,Jackson A,Bachelier R,Clément-Lacroix P,Baron R,Clézardin P,Pujuguet P

    更新日期:2008-01-01 00:00:00

  • Carcinoembryonic antigen (CEA) and its receptor hnRNP M are mediators of metastasis and the inflammatory response in the liver.

    abstract::This article discusses the role of carcinoembryonic antigen (CEA) as a facilitator of the inflammatory response and its effect on colorectal cancer hepatic metastasis. Colorectal cancer accounts for 11% of all cancers in the United States and the majority of deaths are associated with liver metastasis. If left untreat...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章,评审


    authors: Thomas P,Forse RA,Bajenova O

    更新日期:2011-12-01 00:00:00

  • Skeletal impact of 17β-estradiol in T cell-deficient mice: age-dependent bone effects and osteosarcoma formation.

    abstract::Estrogen (E2)-dependent ER+ breast cancer, the most common breast cancer subtype, is also the most likely to metastasize to bone and form osteolytic lesions. However, ER+ breast cancer bone metastasis human xenograft models in nude mice are rarely studied due to complexities associated with distinguishing possible tum...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Cheng JN,Frye JB,Whitman SA,Funk JL

    更新日期:2020-04-01 00:00:00

  • Editorial: Therapy-induced metastasis.

    abstract::The idea for this Special Issue originated from our recent review in Nature Reviews Clinical Oncology entitled "Does the mobilization of circulating tumour cells during cancer therapy cause metastasis?" Martin et al. (Nat Rev Clin Oncol 14:32-44, 2017). While preparing this review, it became evident that an overwhelmi...

    journal_title:Clinical & experimental metastasis

    pub_type: 社论


    authors: Martin OA,Anderson RL

    更新日期:2018-04-01 00:00:00

  • Overview and update of the phase III Multicenter Selective Lymphadenectomy Trials (MSLT-I and MSLT-II) in melanoma.

    abstract::This short review offers an update on the first and second Multicenter Selective Lymphadenectomy Trials (MSLT-I and MSLT-II) for patients with melanoma, and briefly traces the development of intraoperative lymphatic mapping and sentinel node biopsy. ...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章,多中心研究,评审


    authors: Morton DL

    更新日期:2012-10-01 00:00:00

  • Association of SIBA treatment and a Met-depleted diet inhibits in vitro growth and in vivo metastatic spread of experimental tumor cell lines.

    abstract::We have used 5'-deoxy-5'-S isobutyl-thioadenosine (SIBA), an analog of S-adenosylhomocysteine, alone or in association with a methionine-depleted diet in order to obtain an antitumoral effect in two different tumor models: a transplantable rat rhabdomyosarcoma (RMS-J1) induced by i.m. injection of nickel and the well-...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Breillout F,Poupon MF,Blanchard P,Lascaux V,Echinard-Garin P,Robert-Gero M

    更新日期:1988-01-01 00:00:00

  • Dunning rat prostate adenocarcinomas and alternative splicing reporters: powerful tools to study epithelial plasticity in prostate tumors in vivo.

    abstract::Using alternative splicing reporters we have previously observed mesenchymal epithelial transitions in Dunning AT3 rat prostate tumors. We demonstrate here that the Dunning DT and AT3 cells, which express epithelial and mesenchymal markers, respectively, represent an excellent model to study epithelial transitions sin...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Oltean S,Febbo PG,Garcia-Blanco MA

    更新日期:2008-01-01 00:00:00

  • Radiobiology and radiotherapy of brain metastases.

    abstract::Brain metastases are the most common intracranial tumors in adults, accounting for more than 50% of all such cases. The approach to and management of brain metastases have evolved significantly in recent years due to several reasons. These include advances in neurosurgical and radiotherapeutic techniques, improved sys...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章,评审


    authors: Thiagarajan A,Yamada Y

    更新日期:2017-10-01 00:00:00

  • Alterations in Cx43 and OB-cadherin affect breast cancer cell metastatic potential.

    abstract::Emerging evidence suggests that gap junctional intercellular communication (GJIC) and expression of connexins (Cx) contribute to the metastatic potential of breast cancer cells. To more directly address this, an aggressive bone metastasis breast cancer cell line, MDA-MET (MET), was stably transfected with human Cx43 c...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Li Z,Zhou Z,Donahue HJ

    更新日期:2008-01-01 00:00:00

  • Experimental liver metastasis: standards for local cell implantation to study isolated tumor growth in mice.

    abstract::Experimental hepatic metastasis of colorectal tumors is frequently studied by local intrahepatic tumor cell implantation. However, although a variety of factors of the implantation procedure may markedly influence tumor growth characteristics, standards are not defined yet. Herein, we studied the effect of different m...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Kollmar O,Schilling MK,Menger MD

    更新日期:2004-01-01 00:00:00

  • Silencing of skeletal metastasis-associated genes impairs migration of breast cancer cells and reduces osteolytic bone lesions.

    abstract::Bone sialoprotein (BSP) and osteopontin (OPN) are important factors in the metastasis of breast cancer, which were examined as targets for antineoplastic therapy by siRNA. In addition, the effect of gene silencing on their transcription factor Runx2 and their interaction partners integrin β(3) and matrix metalloprotei...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Reufsteck C,Lifshitz-Shovali R,Zepp M,Bäuerle T,Kübler D,Golomb G,Berger MR

    更新日期:2012-06-01 00:00:00

  • Syndecan-1: a dynamic regulator of the myeloma microenvironment.

    abstract::Emerging data in myeloma and other cancers indicates that heparan sulfate proteoglycans promote tumor progression by enhancing their growth and metastasis. By acting as key regulators of cell signaling via their interactions with multiple growth and angiogenic factors, heparan sulfates mediate a shift in the microenvi...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章,评审


    authors: Sanderson RD,Yang Y

    更新日期:2008-01-01 00:00:00

  • Bosentan inhibits tumor vascularization and bone metastasis in an immunocompetent skin-fold chamber model of breast carcinoma cell metastasis.

    abstract::Angiogenic factors including endothelin-1 (ET-1) play a key role in the progression of breast metastases to bone. We investigated the impact of ET-1 on the development of bone metastases in an immunocompetent murine skin-fold chamber model. Murine mammary carcinoma 4T1 was injected in a skin-fold chamber implanted on ...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Dréau D,Karaa A,Culberson C,Wyan H,McKillop IH,Clemens MG

    更新日期:2006-01-01 00:00:00

  • Bone microenvironment-mediated resistance of cancer cells to bisphosphonates and impact on bone osteocytes/stem cells.

    abstract::Anti-resorptive bisphosphonates (BPs) have been clinically used to prevent cancer-bone metastasis and cancer-induced bone pathologies despite the fact that the phenotypic response of the cancer-bone interactions to BP exposure is "uncharted territory". This study offers unique insights into the interplay between cance...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Alasmari A,Lin SC,Dibart S,Salih E

    更新日期:2016-08-01 00:00:00

  • Comparison of metastatic cell lines derived from a murine mammary tumour, and reduction of metastasis by heparin.

    abstract::A murine mammary carcinoma, which had a high potential for metastasis to the lungs, was established in culture, and from the parent line several clonally derived variants were isolated, showing different characteristics including metastatic potential. C1, a high metastatic clone, and C2, a low one, were selected for f...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Lee AE,Rogers LA,Jeffery RE,Longcroft JM

    更新日期:1988-11-01 00:00:00

  • Growth and metastasis of hypermotile, hyperinvasive cancer cells selected in vitro by rapid locomotion under various conditions.

    abstract::Cancer cells selected from a cultured murine fibrosarcoma by rapid migration through micropore membranes moved considerably faster through such membranes and invaded biological tissues much more efficiently than did the unselected parent cells. The present data show that populations of cells selected by unstimulated m...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Grimstad IA

    更新日期:1988-07-01 00:00:00

  • Potentiation of antitumor effect of NKT cell ligand, alpha-galactosylceramide by combination with IL-12 on lung metastasis of malignant melanoma cells.

    abstract::The combined therapeutic effect of natural killer T (NKT) cell ligand alpha-galactosylceramide (alpha-GalCer) and IL-12 against highly metastatic B16-BL6-HM melanoma cells was investigated. In comparison with a single administration of alpha-GalCer or IL-12, the combined treatment of tumor-bearing mice with alpha-GalC...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Nakui M,Ohta A,Sekimoto M,Sato M,Iwakabe K,Yahata T,Kitamura H,Koda T,Kawano T,Makuuchi H,Taniguchi M,Nishimura T

    更新日期:2000-01-01 00:00:00

  • Diagnostic identification of malignant cells in the cerebrospinal fluid by tumor-specific qRT-PCR.

    abstract::Tumor specific quantitative RT-PCRs for two neuroblastoma specific molecular markers, tyrosine hydroxylase (TH) and GD2 synthase, were used to unequivocally demonstrate the neoplastic nature of the cells present in the cerebrospinal fluid of a neuroblastoma patient. After radical surgery of two separate tumoral lesion...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Rosanda C,Gambini C,Carlini B,Conte M,De Bernardi B,Garaventa A,Corrias MV

    更新日期:2006-01-01 00:00:00

  • A novel orthotopic murine model provides insights into cellular and molecular characteristics contributing to human osteosarcoma.

    abstract::As a reliable model for osteosarcoma is lacking, three human cell lines (SaOS-2, U2OS and 143B) were evaluated in cell-based assays for proliferation, adhesion, migration, invasion, anchorage-independent growth, angiogenesis, mineralised nodule formation, plasmid transfection and oligonucleotide transfection. Tumor ta...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Dass CR,Ek ET,Contreras KG,Choong PF

    更新日期:2006-01-01 00:00:00

  • The effect of down regulation of calcineurin Aα by lentiviral vector-mediated RNAi on the biological behavior of small-cell lung cancer and its bone metastasis.

    abstract::Bone is the third most common site of cancer metastasis. Over 30 to 40% of lung cancers can develop skeletal metastasis and no effective curative therapy exists in clinic cases. Previously we screened the different expression of proteins between SBC-5 cells and SBC-3 cells by proteomic study methods (MALDI-TOF/TOF-MS)...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Ma NQ,Liu LL,Min J,Wang JW,Jiang WF,Liu Y,Feng YG,Su HC,Feng YM,Zhang HL

    更新日期:2011-12-01 00:00:00

  • Predictors of prognosis of synchronous brain metastases in small-cell lung cancer patients.

    abstract::Patients with small cell lung cancer (SCLC) are more likely to have synchronous brain metastasis (SBM) at the time of diagnosis than patients with any other extracranial primary malignancy. We sought to identify which factors predicted an increased risk of SBM in SCLC as well as which factors affected the prognosis of...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Reddy SP,Dowell JE,Pan E

    更新日期:2020-08-01 00:00:00