The regulation of prostate cancer cell adhesion to human bone marrow endothelial cell monolayers by androgen dihydrotestosterone and cytokines.

abstract：:We have investigated the gelatinase profiles and invasiveness of clonal tumour sublines derived from a spontaneously arising mammary tumour in a Balb/cfC3H mouse. The 67NR. 66c14 and 4T1.2 sublines have low, intermediate and high metastatic potential respectively. In Boyden chamber studies, Matrigel invasion was seen ...

journal_title：Clinical & experimental metastasis

authors： Tester AM,Ruangpanit N,Anderson RL,Thompson EW

更新日期：2000-01-01 00:00:00

abstract：:Hypermethylation of the promoter region of tumor suppressor genes is associated with carcinogenesis in lung cancer (LC). Endobronchial ultrasound with needle aspiration (EBUS-NA) is a semi-invasive method for obtaining cell blocks from lymph nodes, which can be used for epigenetic analyses. To establish the relationsh...

journal_title：Clinical & experimental metastasis

authors： Millares L,Serra M,Andreo F,Sanz-Santos J,Montón C,Grimau C,Gallego M,Setó L,Combalia N,Llatjos M,Escoda R,Castellà E,Monsó E

更新日期：2015-10-01 00:00:00

abstract：:Osteopontin (OPN) is a glycosylated, secreted phosphoprotein that functions both as a cell attachment and chemotactic factor. Elevated expression of OPN confers enhanced metastatic ability on transformed cells, suggesting that OPN may contribute to the malignant progression of tumors. Migration of mammary carcinoma ce...

journal_title：Clinical & experimental metastasis

authors： Khan SA,Cook AC,Kappil M,Günthert U,Chambers AF,Tuck AB,Denhardt DT

更新日期：2005-01-01 00:00:00

abstract：:Tumor metastases are extremely rare in striated muscles. This is surprising given the fact that this tissue constitutes 60% of body weight. The present study focuses on small molecules produced and secreted by muscle cells which possess anti-cancer activity in vivo. Recently we have shown that a low molecular weight f...

journal_title：Clinical & experimental metastasis

authors： Bar-Yehuda S,Farbstein T,Barer F,Ohana G,Fishman P

更新日期：1999-01-01 00:00:00

abstract：:The purpose of this study was to determine the subpopulation dynamics of human colon carcinoma (HCC) cells growing at orthotopic (cecum, liver) or ectopic (subcutis, kidney, spleen) sites in nude mice and to correlate any outgrowth of distinct clones with the differential expression of metastasis-related genes. Low me...

journal_title：Clinical & experimental metastasis

authors： Singh RK,Tsan R,Radinsky R

更新日期：1997-03-01 00:00:00

abstract：:An overview of colorectal cancer discussed (Philip Paty) the good outcome after primary management with local control in 90-95 % of colon and 85 % in rectal cancer patients with major progression to metastases and to death related to hematogenous dissemination. The major disease pathways include the APC, aneuploid pat...

journal_title：Clinical & experimental metastasis

authors： Wanebo HJ,LeGolvan M,Paty PB,Saha S,Zuber M,D'Angelica MI,Kemeny NE

更新日期：2012-10-01 00:00:00

abstract：:To provide an investigative tool for the study of osteosarcoma (OSA) biology we have developed a syngeneic (balb/c) murine model of OSA, using cell lines derived from a spontaneously occurring murine OSA (Schmidt et al. Differentiation 1988; 39: 151-60). This model is characterized by orthotopic primary tumor growth, ...

journal_title：Clinical & experimental metastasis

authors： Khanna C,Prehn J,Yeung C,Caylor J,Tsokos M,Helman L

更新日期：2000-01-01 00:00:00

abstract：:Melanoma is an aggressive cutaneous malignancy with rapidly rising incidence. Diagnosis of controversial melanocytic lesions, correct prognostication of patients, selection of appropriate adjuvant and systemic therapies, and prediction of response to a given therapy remain very real challenges. Despite these challenge...

journal_title：Clinical & experimental metastasis

authors： Ankeny JS,Labadie B,Luke J,Hsueh E,Messina J,Zager JS

更新日期：2018-08-01 00:00:00

abstract：:Cell motility is an important factor in the process of invasion and metastasis of tumor. In this study, the relationship between cell motility and experimental metastatic potential was examined using two human pancreatic cancer cell lines, SW1990 and PANC-1. Serum-free conditioned medium from the highly metastatic cel...

journal_title：Clinical & experimental metastasis

authors： Sakurai Y,Sawada T,Chung YS,Funae Y,Sowa M

更新日期：1997-05-01 00:00:00

abstract：:Extrathyroidal extension (ETE) of papillary thyroid carcinoma (PTC) is common and clinical presentation can vary from minimal to extensive locoregional involvement. Although PTC is generally considered the most benign among all thyroid carcinomas, it may present with local invasion with poor prognosis. Our retrospecti...

journal_title：Clinical & experimental metastasis

authors： Lin JD,Hsueh C,Chao TC

更新日期：2016-08-01 00:00:00

abstract：:MicroRNAs have been identified as key players in the development and progression of osteosarcoma, which is the most common primary malignancy of bone. Sequencing-based miR-omic and quantitative real-time PCR analyses suggested that the expression of miR-193a-3p and miR-193a-5p was decreased by DNA methylation at their...

journal_title：Clinical & experimental metastasis

authors： Pu Y,Zhao F,Cai W,Meng X,Li Y,Cai S

更新日期：2016-04-01 00:00:00

abstract：:Breast cancer has a predilection for metastasis to the bone marrow. The preprotachykinin-I (PPT-I) gene has a central role in the early migration of breast cancer cells into the bone marrow, making this organ a latent repository of the cancer cells. This study investigated whether the invasive and metastatic potential...

journal_title：Clinical & experimental metastasis

authors： Castro TA,Cohen MC,Rameshwar P

更新日期：2005-01-01 00:00:00

abstract：:Breast cancer (BC) is the most common cancer affecting women in the United States and metastatic breast cancer is the leading cause of death. The role estradiol plays in ER-positive BC is well-documented, but the way it contributes to ER-negative BC remains unclear. In the present study, we utilized an experimental mo...

journal_title：Clinical & experimental metastasis

authors： Yang X,Belosay A,Du M,Fan TM,Turner RT,Iwaniec UT,Helferich WG

更新日期：2013-08-01 00:00:00

abstract：:Numerous cancer patients fail standard chemotherapy or develop resistance to chemotherapy during the course of treatment. The purpose of this study is to elucidate the overall response of cells obtained from cancer patients and from normal individuals to chemotherapeutic agents. We analysed the chemosensitivity of can...

journal_title：Clinical & experimental metastasis

authors： Richard C,Yau J,Th'ng JP,Duivenvoorden WC

更新日期：2006-01-01 00:00:00

abstract：:Bone sialoprotein (BSP) and osteopontin (OPN) are important factors in the metastasis of breast cancer, which were examined as targets for antineoplastic therapy by siRNA. In addition, the effect of gene silencing on their transcription factor Runx2 and their interaction partners integrin β(3) and matrix metalloprotei...

journal_title：Clinical & experimental metastasis

authors： Reufsteck C,Lifshitz-Shovali R,Zepp M,Bäuerle T,Kübler D,Golomb G,Berger MR

更新日期：2012-06-01 00:00:00

abstract：:Inflammatory breast cancer (IBC) is the most lethal form of locally advanced breast cancer known. IBC carries a guarded prognosis primarily due to rapid onset of disease, typically within six months, and the propensity of tumor emboli to invade the dermal lymphatics and spread systemically. Although the clinical manif...

journal_title：Clinical & experimental metastasis

authors： van Golen KL,Bao LW,Pan Q,Miller FR,Wu ZF,Merajver SD

更新日期：2002-01-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a potent angiogenic growth factor with a key role in many physiological and pathological processes. Investigation into the implications of circulating levels of this cytokine is progressing at an exponential rate. However, there are important inconsistencies between reports...

journal_title：Clinical & experimental metastasis

authors： Hormbrey E,Gillespie P,Turner K,Han C,Roberts A,McGrouther D,Harris AL

更新日期：2002-01-01 00:00:00

abstract：:The glycosaminoglycans (GAGs) of low (LM) and highly metastatic (HM) cell lines of the Lewis lung tumour (3LL) were compared using [3H]glucosamine labelling techniques. The GAGs isolated from nuclei, cytoplasm, pericellular fractions and medium were analysed by cellulose acetate electrophoresis and by digestion with s...

journal_title：Clinical & experimental metastasis

authors： Pogány G,Moczar E,Jeney A,Timár J,Timár F,Ditrói K,Lapis K

更新日期：1989-11-01 00:00:00

abstract：:Previous studies from our laboratory have demonstrated that metastatic propensity is significantly influenced by the genetic background upon which tumors arise. We have also established that human gene expression profiles predictive of metastasis are not only present in mouse tumors with both high and low metastatic c...

journal_title：Clinical & experimental metastasis

authors： Yang H,Crawford N,Lukes L,Finney R,Lancaster M,Hunter KW

更新日期：2005-01-01 00:00:00

abstract：:It is generally accepted that recent advances in anticancer agents have contributed significantly to the improvement of both the disease-free survival and quality of life in cancer patients. However, in many instances, a favorable initial response to treatment changes afterwards, thereby leading to cancer relapse and ...

journal_title：Clinical & experimental metastasis

authors： Nikolaou M,Pavlopoulou A,Georgakilas AG,Kyrodimos E

更新日期：2018-04-01 00:00:00

abstract：:MACC1 (metastasis associated in colon cancer 1) is a key driver that induces metastasis in colon cancer. However, the mechanisms by which MACC1 expression is transcriptionally regulated and the factors enriched at the MACC1 promoter remain largely unknown. The binding of proteins to specific DNA sites in the genome is...

journal_title：Clinical & experimental metastasis

authors： Huang Y,Xiang Y,Xie Z,Cai Y,Yang Q,Huang H,Chen Z,Xiao Z,He Q

更新日期：2020-08-01 00:00:00

abstract：:Patients with small cell lung cancer (SCLC) are more likely to have synchronous brain metastasis (SBM) at the time of diagnosis than patients with any other extracranial primary malignancy. We sought to identify which factors predicted an increased risk of SBM in SCLC as well as which factors affected the prognosis of...

journal_title：Clinical & experimental metastasis

authors： Reddy SP,Dowell JE,Pan E

更新日期：2020-08-01 00:00:00

abstract：:MUC1 is a transmembrane glycoprotein expressed by normal breast epithelium and virtually all breast cancers. MUC1 is normally restricted to the apical surface of epithelia and loss of this polarized distribution in breast carcinomas is associated with lymph node metastasis. Our previous work found that MUC1 can bind i...

journal_title：Clinical & experimental metastasis

authors： Rahn JJ,Chow JW,Horne GJ,Mah BK,Emerman JT,Hoffman P,Hugh JC

更新日期：2005-01-01 00:00:00

abstract：:Metastasis, responsible for most deaths from breast cancer (BC), is a multistep process leading to cancer cell spread. Extracellular matrix (ECM)-related adhesion and apoptosis resistance play pivotal role in metastasis. Ras suppressor-1 (RSU-1) localizes to cell-ECM adhesions and binds to pro-survival adhesion protei...

journal_title：Clinical & experimental metastasis

authors： Giotopoulou N,Valiakou V,Papanikolaou V,Dubos S,Athanassiou E,Tsezou A,Zacharia LC,Gkretsi V

更新日期：2015-03-01 00:00:00

abstract：:Brain metastases present a significant public health issue, affecting more than 100,000 patients per year in the U.S. and result in significant morbidity. Brain metastases can occur in a variety of clinical situations ranging from multiple brain metastases with uncontrolled systemic disease to a solitary metastasis in...

journal_title：Clinical & experimental metastasis

authors： Ferguson SD,Wagner KM,Prabhu SS,McAleer MF,McCutcheon IE,Sawaya R

更新日期：2017-10-01 00:00:00

abstract：:Spatial and temporal oxygen heterogeneity exists in most solid tumour microenvironments due to an inadequate vascular network supplying a dense population of tumour cells. An imbalance between oxygen supply and demand leads to hypoxia within a significant proportion of a tumour, which has been correlated to the likeli...

journal_title：Clinical & experimental metastasis

authors： Subarsky P,Hill RP

更新日期：2008-01-01 00:00:00

abstract：:To study the tumor cell autonomous processes of metastasis, an in vivo tumor metastasis model is required that excludes the involvement of the innate immune system. For this purpose we used the established syngeneic MTLn3 cell - Fischer 344 tumor model. MTLn3 cells are efficiently eradicated by NK cells in vivo. Using...

journal_title：Clinical & experimental metastasis

authors： van Nimwegen MJ,Verkoeijen S,Kuppen PJ,Velthuis JH,van de Water B

更新日期：2007-01-01 00:00:00

abstract：:The complex process of tumor invasion requires the coordinated expression and activity of cell-substratum adhesive interactions and of cell-associated protease systems, which destroy the extracellular matrix (ECM), in order to enable the invading cells to simultaneously grip and destroy the anatomical barriers that co...

journal_title：Clinical & experimental metastasis

authors： Del Rosso M,Fibbi G,Pucci M,D'Alessio S,Del Rosso A,Magnelli L,Chiarugi V

更新日期：2002-01-01 00:00:00

abstract：:Sentinel lymph node (SLN) mapping is common, however question remains as to what the ideal imaging agent is and how such an agent might provide reliable and stable localization of SLNs. (99m)Tc-labeled nanocolloid human serum albumin (Nanocoll) is the most commonly used radio-labeled colloid in Europe and remains the ...

journal_title：Clinical & experimental metastasis

authors： Tokin CA,Cope FO,Metz WL,Blue MS,Potter BM,Abbruzzese BC,Hartman RD,Joy MT,King DW,Christman LA,Vera DR,Wallace AM

更新日期：2012-10-01 00:00:00

abstract：:The effect of thioglycollate-elicited macrophages (TG-M phi) on natural killer (NK)-cell activity and metastases formation in mice was investigated. Intravenously (i.v.) inoculated TG-M phi inhibited spleen NK activity of normal mice and abrogated polyinosinic: polycytidylic (poly I:C) induced augmentation of NK cell ...

journal_title：Clinical & experimental metastasis

authors： Gorelik E,Wiltrout RH,Brunda MJ,Bere WE,Herberman RB

更新日期：1985-04-01 00:00:00