The regulation of prostate cancer cell adhesion to human bone marrow endothelial cell monolayers by androgen dihydrotestosterone and cytokines.

abstract：:Inflammatory breast cancer (IBC) is the most lethal form of locally advanced breast cancer known. IBC carries a guarded prognosis primarily due to rapid onset of disease, typically within six months, and the propensity of tumor emboli to invade the dermal lymphatics and spread systemically. Although the clinical manif...

journal_title：Clinical & experimental metastasis

authors： van Golen KL,Bao LW,Pan Q,Miller FR,Wu ZF,Merajver SD

更新日期：2002-01-01 00:00:00

abstract：:High grade serous ovarian tumors often metastasize transperitoneally, a process that begins when small tumor nodules de-adhere and are released into the fluid of the abdominal cavity where they float freely to reach new sites on the peritoneal wall. Podocalyxin, a small anti-adhesive sialomucin, has been shown to cont...

journal_title：Clinical & experimental metastasis

authors： Cipollone JA,Graves ML,Köbel M,Kalloger SE,Poon T,Gilks CB,McNagny KM,Roskelley CD

更新日期：2012-03-01 00:00:00

abstract：:The urokinase-type plasminogen activator (UPA) and its inhibitor PAI-1 are thought to play an important part in gastric cancer (GC) invasion and metastasis. Little is known about the behavior and prognostic impact of the receptor for UPA (UPAR). The aims of the present study were: (1) to measure UPAR, UPA and PAI-1 le...

journal_title：Clinical & experimental metastasis

authors： Plebani M,Herszènyi L,Carraro P,De Paoli M,Roveroni G,Cardin R,Tulassay Z,Naccarato R,Farinati F

更新日期：1997-07-01 00:00:00

abstract：:Estrogen (E2)-dependent ER+ breast cancer, the most common breast cancer subtype, is also the most likely to metastasize to bone and form osteolytic lesions. However, ER+ breast cancer bone metastasis human xenograft models in nude mice are rarely studied due to complexities associated with distinguishing possible tum...

journal_title：Clinical & experimental metastasis

authors： Cheng JN,Frye JB,Whitman SA,Funk JL

更新日期：2020-04-01 00:00:00

abstract：:The present study assessed the effects of dietary fat on spontaneous metastasis of Lewis lung carcinoma in mice. Three-week old male C57BL/6 mice were fed the AIN-93G diet or a 45% fat diet (% kcal.) for 7 weeks before they were subcutaneously injected with 2.5 × 10⁵ viable carcinoma cells. The primary tumor was resec...

journal_title：Clinical & experimental metastasis

authors： Yan L,DeMars LC

更新日期：2010-12-01 00:00:00

abstract：:The interaction between circulating tumor cells and blood components, mainly platelets, plays an important role during metastasis. In this study, we prepared liposomes containing the platelet aggregation inhibitor Cilostazol (Cil-L). The objective of this study was to investigate the effect of this Cil-L on platelet a...

journal_title：Clinical & experimental metastasis

authors： Wenzel J,Zeisig R,Fichtner I

更新日期：2010-01-01 00:00:00

abstract：:Bone is the third most common site of cancer metastasis. Over 30 to 40% of lung cancers can develop skeletal metastasis and no effective curative therapy exists in clinic cases. Previously we screened the different expression of proteins between SBC-5 cells and SBC-3 cells by proteomic study methods (MALDI-TOF/TOF-MS)...

journal_title：Clinical & experimental metastasis

authors： Ma NQ,Liu LL,Min J,Wang JW,Jiang WF,Liu Y,Feng YG,Su HC,Feng YM,Zhang HL

更新日期：2011-12-01 00:00:00

abstract：:Primary tumor growth and metastasis depend on angiogenesis, which is determined by the balance between proangiogenic and antiangiogenic molecules. Interferon (IFN)-alpha and -beta inhibit angiogenesis through downregulation of interleukin-8, matrix metalloproteinase-9, and basic fibroblast growth factor. To provide ev...

journal_title：Clinical & experimental metastasis

authors： McCarty MF,Bielenberg D,Donawho C,Bucana CD,Fidler IJ

更新日期：2002-01-01 00:00:00

abstract：:We have investigated the gelatinase profiles and invasiveness of clonal tumour sublines derived from a spontaneously arising mammary tumour in a Balb/cfC3H mouse. The 67NR. 66c14 and 4T1.2 sublines have low, intermediate and high metastatic potential respectively. In Boyden chamber studies, Matrigel invasion was seen ...

journal_title：Clinical & experimental metastasis

authors： Tester AM,Ruangpanit N,Anderson RL,Thompson EW

更新日期：2000-01-01 00:00:00

abstract：:RANK ligand (RANKL), acting through its cognate receptor RANK, is a key factor for bone remodeling and metastasis by regulating the differentiation, survival and activation of osteoclasts. RANKL is also crucial for the development of mouse mammary glands during pregnancy and has been recently linked to the etiology of...

journal_title：Clinical & experimental metastasis

authors： Blake ML,Tometsko M,Miller R,Jones JC,Dougall WC

更新日期：2014-02-01 00:00:00

abstract：:The purpose of this study was to identify possible alterations in proto-oncogenes (c-fos, c-jun, c-erbB1, c-erbB2 and c-myc) at the protein level in primary lung carcinomas and simultaneous metastatic lymph nodes of 21 patients. The analysis showed that proteins of c-jun and c-myc were expressed in a significantly hig...

journal_title：Clinical & experimental metastasis

authors： Volm M,van Kaick G,Mattern J

更新日期：1994-07-01 00:00:00

abstract：:Numerous cancer patients fail standard chemotherapy or develop resistance to chemotherapy during the course of treatment. The purpose of this study is to elucidate the overall response of cells obtained from cancer patients and from normal individuals to chemotherapeutic agents. We analysed the chemosensitivity of can...

journal_title：Clinical & experimental metastasis

authors： Richard C,Yau J,Th'ng JP,Duivenvoorden WC

更新日期：2006-01-01 00:00:00

abstract：:Bone sialoprotein (BSP) and osteopontin (OPN) are important factors in the metastasis of breast cancer, which were examined as targets for antineoplastic therapy by siRNA. In addition, the effect of gene silencing on their transcription factor Runx2 and their interaction partners integrin β(3) and matrix metalloprotei...

journal_title：Clinical & experimental metastasis

authors： Reufsteck C,Lifshitz-Shovali R,Zepp M,Bäuerle T,Kübler D,Golomb G,Berger MR

更新日期：2012-06-01 00:00:00

abstract：:The effects of gamma-irradiation on the properties of microvessel endothelial cells were studied in vitro. After incubating confluent endothelial cell monolayers in low serum-containing medium for 24 h, the monolayers were irradiated with 137Cs. Survival of rat lung microvessel endothelial (RLE) and mouse brain microv...

journal_title：Clinical & experimental metastasis

authors： Nicolson GL,Custead SE,Dulski KM,Milas L

更新日期：1991-09-01 00:00:00

abstract：:To study the tumor cell autonomous processes of metastasis, an in vivo tumor metastasis model is required that excludes the involvement of the innate immune system. For this purpose we used the established syngeneic MTLn3 cell - Fischer 344 tumor model. MTLn3 cells are efficiently eradicated by NK cells in vivo. Using...

journal_title：Clinical & experimental metastasis

authors： van Nimwegen MJ,Verkoeijen S,Kuppen PJ,Velthuis JH,van de Water B

更新日期：2007-01-01 00:00:00

abstract：:Considering recent findings that cyclooxygensase-2 (COX-2) is involved in the progression of colorectal carcinoma (CRC), the role of COX-2 in promoting invasion and angiogenesis was investigated by evaluating the relationship of COX-2 expression to various clinicopathological variables, including plasminogen activatin...

journal_title：Clinical & experimental metastasis

authors： Konno H,Baba M,Shoji T,Ohta M,Suzuki S,Nakamura S

更新日期：2002-01-01 00:00:00

abstract：:In order to study the usefulness of treatment with vinblastine (VLB) in the prevention of cancer metastasis in squamous cell lung cancer, 50 patients with locoregional disease were randomized to receive either locoregional RT alone (group A) or a weekly intravenous bolus injection of VLB (6 mg/m2) concurrently with an...

journal_title：Clinical & experimental metastasis

authors： Schallier DC,De Neve WJ,De Greve JL,Van Belle SP,De Wasch GJ,Dotremont G,Storme GA

更新日期：1988-01-01 00:00:00

abstract：:Lymph node metastasis is the main prognosis factor in a number of malignancies, including breast carcinomas. The means by which lymph node metastases arise is not fully understood, and many questions remain about their importance in the further spread of breast cancer. Nevertheless, a number of key cellular and molecu...

journal_title：Clinical & experimental metastasis

authors： Eccles S,Paon L,Sleeman J

更新日期：2007-01-01 00:00:00

abstract：:This study compared phenotype and behaviour of seven head and neck squamous cell carcinoma (HNSCC) cell lines and normal epithelial cells. Indications were found that in HNSCC cells: 1) loss of the cell-cell adhesion molecule E-cadherin was correlated with loss of epithelioid cell morphology but not with loss of cell-...

journal_title：Clinical & experimental metastasis

authors： Tomson AM,Scholma J,Meijer B,Koning JG,de Jong KM,van der Werf M

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Metastasis to bone from endometrial adenocarcinoma is rare, when metastasises it usually locates in axial skeleton. Metastasis to extremities is extremely rare. Additionally the detection of the bone metastasis as a presenting feature is uncommon. In the present study we report the 10th cases of bone metasta...

journal_title：Clinical & experimental metastasis

authors： Kaya A,Olmezoglu A,Eren CS,Bayol U,Altay T,Karapinar L,Ozturk H,Oztekin D,Guvenli Y,Karadogan I

更新日期：2007-01-01 00:00:00

abstract：:Breast cancer metastasizes to bone with high frequency and incidence. However, studies of breast cancer metastasis to bone have been limited by two factors. First, the number of models that colonize bone are limited. Second, detection of bone metastases is too insensitive or too laborious for routine, large-scale stud...

journal_title：Clinical & experimental metastasis

authors： Harms JF,Welch DR

更新日期：2003-01-01 00:00:00

abstract：:A variant cell line (EL-4ad) which adhered to a tissue culture dish was isolated from highly metastatic EL-4 murine T-lymphoma. The experimental and spontaneous metastatic ability of EL-4ad was lower than that of the EL-4 parent cell line. The cell surface phenotypes of both cell lines were CD2+3+4-8-45+TCR alpha beta...

journal_title：Clinical & experimental metastasis

authors： Ota T,Tanino M,Kohno H,Funamoto H,Odashima S

更新日期：1992-09-01 00:00:00

abstract：:We have previously reported that transfection of mouse interferon gamma (IFN-gamma) in H-2Kk-positive BW variants (BW-Sp3) abolishes tumorigenicity and reduces metastatic capacity. To further increase the immunogenicity of BW-Sp3 cells, the gene for human interleukin 2 (huIL-2) was transfected in these cancer cells. S...

journal_title：Clinical & experimental metastasis

authors： Geldhof AB,Van Ginderachter J,Vandersteen P,Raes G,De Baetselier P

更新日期：1998-07-01 00:00:00

abstract：:Tumor cell adhesion to the extracellular matrix (ECM) is closely linked with tumor cell invasion and metastasis. In this study, we demonstrate that low levels of adriamycin, a widely used anticancer drug, can inhibit the invasion of highly metastatic K1735-M2 mouse melanoma cells in vitro through a reconstituted basem...

journal_title：Clinical & experimental metastasis

authors： Repesh LA,Drake SR,Warner MC,Downing SW,Jyring R,Seftor EA,Hendrix MJ,McCarthy JB

更新日期：1993-01-01 00:00:00

abstract：:Single cell progenies (SCPs) inherit biological properties from their isogenetic mother cells. If a single cancer cell can give rise to progenies, which can be passaged sustainably in vitro and produce tumor in xenotransplantation, the cell should be cancer initiating cell. CD133 (Prominin-1, Prom1) is the marker of h...

journal_title：Clinical & experimental metastasis

authors： Li G,Liu C,Yuan J,Xiao X,Tang N,Hao J,Wang H,Bian X,Deng Y,Ding Y

更新日期：2010-10-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide with increasing incidence. Despite curative surgical resection and advanced chemotherapy, its survival rate remains low. The presence of microvascular invasion and occult metastasis is one of the major causes for this poor outcome. MDM2 Binding...

journal_title：Clinical & experimental metastasis

authors： Bi Q,Ranjan A,Fan R,Agarwal N,Welch DR,Weinman SA,Ding J,Iwakuma T

更新日期：2015-04-01 00:00:00

abstract：:Sentinel lymph node (SLN) identification with preoperative image guidance may improve pathological staging of prostate cancer by identifying nodes outside the standard template of dissection. Four anesthetized male dogs received an intra-prostatic injection of Ga-68-labeled tilmanocept. Every 20 min the pelvic lymph n...

journal_title：Clinical & experimental metastasis

authors： Stroup SP,Kane CJ,Farchshchi-Heydari S,James CM,Davis CH,Wallace AM,Hoh CK,Vera DR

更新日期：2012-10-01 00:00:00

abstract：:Mouse mammary carcinoma cells were exposed in vitro to increasing concentrations of doxorubicin hydrochloride [adriamycin (ADR)] or 5-fluorouracil (5-FU). Uptake of [75Se]selenomethionine (75SeM) in a methionine-deficient medium measured the resulting inhibition of protein synthesis by the tumour cells. This was compa...

journal_title：Clinical & experimental metastasis

authors： Lai T,Stonebridge BR,Black J,Symes MO

更新日期：1989-07-01 00:00:00

abstract：:In this study the relationship between brain structure and brain metastases (BM) occurrence was analyzed. A model for predicting the time of BM onset in patients with non-small cell lung cancer (NSCLC) was proposed. Twenty patients were used to develop the model, whereas the remaining 69 were used for independent vali...

journal_title：Clinical & experimental metastasis

authors： Yin G,Li C,Chen H,Luo Y,Orlandini LC,Wang P,Lang J

更新日期：2017-02-01 00:00:00

abstract：:We applied reverse phase protein microarrays technology to map signal pathway interactions in a discovery set of 34 soft tissue sarcoma (STS) bone metastases compared to healthy bone. Proteins associated with matrix remodeling (MMP), adhesion (FAK Y576/577, Syndecan-1), and growth/survival (IGF1R Y1135/1136, PI3K, EGF...

journal_title：Clinical & experimental metastasis

authors： Conti A,Espina V,Chiechi A,Magagnoli G,Novello C,Pazzaglia L,Quattrini I,Picci P,Liotta LA,Benassi MS

更新日期：2014-01-01 00:00:00