Lymphatic metastasis in breast cancer: importance and new insights into cellular and molecular mechanisms.

abstract：:We have used 5'-deoxy-5'-S isobutyl-thioadenosine (SIBA), an analog of S-adenosylhomocysteine, alone or in association with a methionine-depleted diet in order to obtain an antitumoral effect in two different tumor models: a transplantable rat rhabdomyosarcoma (RMS-J1) induced by i.m. injection of nickel and the well-...

journal_title：Clinical & experimental metastasis

authors： Breillout F,Poupon MF,Blanchard P,Lascaux V,Echinard-Garin P,Robert-Gero M

更新日期：1988-01-01 00:00:00

abstract：:To elucidate the development of bone metastasis in human neuroblastoma, bone marrow and bone metastases were analysed histologically in a hematogeneous metastasis model of murine neuroblastoma. The bone marrow metastasis occurred initially in the bone marrow sinusoid where tumor cells adhered and extravasated to bone ...

journal_title：Clinical & experimental metastasis

authors： Yoshino K,Tanabe M,Ohnuma N,Takahashi H

更新日期：1996-10-01 00:00:00

abstract：:To analyze the prognostic value of the extent of peritumoral brain edema in patients operated for single brain metastases (BM), we retrospectively evaluated pre-operative magnetic resonance images in a discovery cohort of 129 patients and a validation cohort of 118 patients, who underwent neurosurgical resection of a ...

journal_title：Clinical & experimental metastasis

authors： Spanberger T,Berghoff AS,Dinhof C,Ilhan-Mutlu A,Magerle M,Hutterer M,Pichler J,Wöhrer A,Hackl M,Widhalm G,Hainfellner JA,Dieckmann K,Marosi C,Birner P,Prayer D,Preusser M

更新日期：2013-04-01 00:00:00

abstract：:Previous studies from our laboratory have demonstrated that metastatic propensity is significantly influenced by the genetic background upon which tumors arise. We have also established that human gene expression profiles predictive of metastasis are not only present in mouse tumors with both high and low metastatic c...

journal_title：Clinical & experimental metastasis

authors： Yang H,Crawford N,Lukes L,Finney R,Lancaster M,Hunter KW

更新日期：2005-01-01 00:00:00

abstract：:Breast cancer has a predilection for metastasis to the bone marrow. The preprotachykinin-I (PPT-I) gene has a central role in the early migration of breast cancer cells into the bone marrow, making this organ a latent repository of the cancer cells. This study investigated whether the invasive and metastatic potential...

journal_title：Clinical & experimental metastasis

authors： Castro TA,Cohen MC,Rameshwar P

更新日期：2005-01-01 00:00:00

abstract：:The interaction between circulating tumor cells and blood components, mainly platelets, plays an important role during metastasis. In this study, we prepared liposomes containing the platelet aggregation inhibitor Cilostazol (Cil-L). The objective of this study was to investigate the effect of this Cil-L on platelet a...

journal_title：Clinical & experimental metastasis

authors： Wenzel J,Zeisig R,Fichtner I

更新日期：2010-01-01 00:00:00

abstract：:Metastasis, responsible for most deaths from breast cancer (BC), is a multistep process leading to cancer cell spread. Extracellular matrix (ECM)-related adhesion and apoptosis resistance play pivotal role in metastasis. Ras suppressor-1 (RSU-1) localizes to cell-ECM adhesions and binds to pro-survival adhesion protei...

journal_title：Clinical & experimental metastasis

authors： Giotopoulou N,Valiakou V,Papanikolaou V,Dubos S,Athanassiou E,Tsezou A,Zacharia LC,Gkretsi V

更新日期：2015-03-01 00:00:00

abstract：:Breast cancer metastasis to the brain develops after a clinical latency of years to even decades, suggesting that colonization of the brain is the most challenging step of the metastatic cascade. However, the underlying mechanisms used by breast cancer cells to successfully colonize the brain's microenvironment remain...

journal_title：Clinical & experimental metastasis

authors： Jandial R,Choy C,Levy DM,Chen MY,Ansari KI

更新日期：2017-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide with increasing incidence. Despite curative surgical resection and advanced chemotherapy, its survival rate remains low. The presence of microvascular invasion and occult metastasis is one of the major causes for this poor outcome. MDM2 Binding...

journal_title：Clinical & experimental metastasis

authors： Bi Q,Ranjan A,Fan R,Agarwal N,Welch DR,Weinman SA,Ding J,Iwakuma T

更新日期：2015-04-01 00:00:00

abstract：:Matrilysin is a member of the matrix metalloproteinase gene family which is believed to play an important role in tumor progression. Expression of matrilysin mRNA was examined by reverse transcription-polymerase chain reaction combined with Southern blot analysis in 46 human primary gastric cancers. Overexpression of ...

journal_title：Clinical & experimental metastasis

authors： Senota A,Itoh F,Yamamoto H,Adachi Y,Hinoda Y,Imai K

更新日期：1998-05-01 00:00:00

abstract：:High grade serous ovarian tumors often metastasize transperitoneally, a process that begins when small tumor nodules de-adhere and are released into the fluid of the abdominal cavity where they float freely to reach new sites on the peritoneal wall. Podocalyxin, a small anti-adhesive sialomucin, has been shown to cont...

journal_title：Clinical & experimental metastasis

authors： Cipollone JA,Graves ML,Köbel M,Kalloger SE,Poon T,Gilks CB,McNagny KM,Roskelley CD

更新日期：2012-03-01 00:00:00

abstract：:Osteopontin (OPN) is a glycosylated, secreted phosphoprotein that functions both as a cell attachment and chemotactic factor. Elevated expression of OPN confers enhanced metastatic ability on transformed cells, suggesting that OPN may contribute to the malignant progression of tumors. Migration of mammary carcinoma ce...

journal_title：Clinical & experimental metastasis

authors： Khan SA,Cook AC,Kappil M,Günthert U,Chambers AF,Tuck AB,Denhardt DT

更新日期：2005-01-01 00:00:00

abstract：:The concurrent administration of Metrazol (60 mg/kg, i.v.) to anaesthetized rats enhances the cerebral penetration of the anticancer agent razoxane. Such an enhancement leads to an increase in the therapeutic efficacy of razoxane against intracerebrally sequestered L1210 leukaemia cells in mice. The combination of Met...

journal_title：Clinical & experimental metastasis

authors： Greig N,Newell D,Hellmann K

更新日期：1984-01-01 00:00:00

abstract：:Recombinant murine interferon beta (MuIFN-beta) given i.v. efficiently inhibited both pulmonary arrest and formation of lung colonies of NL-17, a highly metastatic variant of mouse colon adenocarcinoma 26. NL-17 was rather resistant to MuIFN-beta in vitro and was highly resistant to natural killer cells of mice even t...

journal_title：Clinical & experimental metastasis

authors： Tsuruo T,Saito H,Watanabe M,Sugimoto Y,Yamori T,Oh-Hara T

更新日期：1990-03-01 00:00:00

abstract：:Immunotherapy by vaccination represents a novel method for treatment of cancer. In this regard, vaccines with the broadest possible menu of relevant antigens stand the greatest chance of success. Tissue vaccines are composed of material harvested directly from tumors and contain not only antigens associated with neopl...

journal_title：Clinical & experimental metastasis

authors： Suckow MA,Wolter WR,Sailes VT

更新日期：2008-01-01 00:00:00

abstract：:Angiogenic cytokines in the plasma and serum of cancer patients may serve as 'surrogate' markers of tumour neoangiogenesis. Serum VEGF correlates with disease stage in colorectal cancer (CRC), but the role of bFGF in CRC is uncertain. This study aimed to assess plasma bFGF levels in CRC patients before treatment, duri...

journal_title：Clinical & experimental metastasis

authors： George ML,Tutton MG,Abulafi AM,Eccles SA,Swift RI

更新日期：2002-01-01 00:00:00

abstract：:Protein kinase C (PKC) has been shown to be a signal transducer during tumorigenesis, tumor cell invasion, and metastasis. Recent studies have reported that the PKC inhibitor, 7-hydroxystaurosporine, inhibits tumor cell invasion. However, the molecular mechanisms of this inhibition of invasion and metastasis are not w...

journal_title：Clinical & experimental metastasis

authors： Tsubaki M,Matsuoka H,Yamamoto C,Kato C,Ogaki M,Satou T,Itoh T,Kusunoki T,Tanimori Y,Nishida S

更新日期：2007-01-01 00:00:00

abstract：:Patients with small cell lung cancer (SCLC) are more likely to have synchronous brain metastasis (SBM) at the time of diagnosis than patients with any other extracranial primary malignancy. We sought to identify which factors predicted an increased risk of SBM in SCLC as well as which factors affected the prognosis of...

journal_title：Clinical & experimental metastasis

authors： Reddy SP,Dowell JE,Pan E

更新日期：2020-08-01 00:00:00

abstract：:Breast cancer metastasizes to bone with high frequency and incidence. However, studies of breast cancer metastasis to bone have been limited by two factors. First, the number of models that colonize bone are limited. Second, detection of bone metastases is too insensitive or too laborious for routine, large-scale stud...

journal_title：Clinical & experimental metastasis

authors： Harms JF,Welch DR

更新日期：2003-01-01 00:00:00

abstract：:Hypermethylation of the promoter region of tumor suppressor genes is associated with carcinogenesis in lung cancer (LC). Endobronchial ultrasound with needle aspiration (EBUS-NA) is a semi-invasive method for obtaining cell blocks from lymph nodes, which can be used for epigenetic analyses. To establish the relationsh...

journal_title：Clinical & experimental metastasis

authors： Millares L,Serra M,Andreo F,Sanz-Santos J,Montón C,Grimau C,Gallego M,Setó L,Combalia N,Llatjos M,Escoda R,Castellà E,Monsó E

更新日期：2015-10-01 00:00:00

abstract：:The purpose of this study was to determine the subpopulation dynamics of human colon carcinoma (HCC) cells growing at orthotopic (cecum, liver) or ectopic (subcutis, kidney, spleen) sites in nude mice and to correlate any outgrowth of distinct clones with the differential expression of metastasis-related genes. Low me...

journal_title：Clinical & experimental metastasis

authors： Singh RK,Tsan R,Radinsky R

更新日期：1997-03-01 00:00:00

abstract：:To evaluate the local control (LC), progression free survival (PFS), out-field PFS, overall survival (OS), toxicity and failure predictors of SRT in a series of various sites oligometastatic CRC patients. Patients with oligometastatic CRC disease were analyzed retrospectively. The SRT prescribed dose was dependent on ...

journal_title：Clinical & experimental metastasis

authors： Dell'Acqua V,Surgo A,Kraja F,Kobiela J,Zerella MA,Spychalski P,Gandini S,Francia CM,Ciardo D,Fodor C,Ferrari AM,Piperno G,Cattani F,Vigorito S,Pansini F,Petz W,Orecchia R,Leonardi MC,Jereczek-Fossa BA

更新日期：2019-08-01 00:00:00

abstract：:CNTO 95 is a fully human monoclonal antibody that recognizes alphav integrins. Previous studies have shown that CNTO 95 exhibits both anti-tumor and anti-angiogenic activities (Trikha M et al., Int J Cancer 110:326-335, 2004). In this study we investigated the biological activities of CNTO 95 on breast tumor cells bot...

journal_title：Clinical & experimental metastasis

authors： Chen Q,Manning CD,Millar H,McCabe FL,Ferrante C,Sharp C,Shahied-Arruda L,Doshi P,Nakada MT,Anderson GM

更新日期：2008-01-01 00:00:00

abstract：:In order to study the usefulness of treatment with vinblastine (VLB) in the prevention of cancer metastasis in squamous cell lung cancer, 50 patients with locoregional disease were randomized to receive either locoregional RT alone (group A) or a weekly intravenous bolus injection of VLB (6 mg/m2) concurrently with an...

journal_title：Clinical & experimental metastasis

authors： Schallier DC,De Neve WJ,De Greve JL,Van Belle SP,De Wasch GJ,Dotremont G,Storme GA

更新日期：1988-01-01 00:00:00

abstract：:Morbidity and mortality of breast cancer patients are drastically increased when primary tumor cells are able to spread to distant sites and proliferate to become secondary lesions. Effective treatment of metastatic disease has been limited; therefore, an increased molecular understanding to identify biomarkers and th...

journal_title：Clinical & experimental metastasis

authors： Cook LM,Cao X,Dowell AE,Debies MT,Edmonds MD,Beck BH,Kesterson RA,Desmond RA,Frost AR,Hurst DR,Welch DR

更新日期：2012-04-01 00:00:00

abstract：:Recently the concept that gap junctions play a role in cancer cell metastasis has emerged. However, the mechanism by which this might occur is unknown. To examine this issue a metastatic breast cancer cell line, MDA-MB-435, was stably transfected with human Cx43 cDNA. Four clones of 435 transfectants (435/Cx43(+) c1, ...

journal_title：Clinical & experimental metastasis

authors： Li Z,Zhou Z,Welch DR,Donahue HJ

更新日期：2008-01-01 00:00:00

abstract：:Breast cancer dissemination can be monitored in patients by detecting circulating and/or disseminated tumor cells. However, bone marrow disseminated tumor cells (BM DTC) may undergo a dormancy during several years before growing (or not) into clinically detectable metastases. We therefore hypothesized that breast canc...

journal_title：Clinical & experimental metastasis

authors： Bidard FC,Vincent-Salomon A,Sigal-Zafrani B,Rodrigues M,Diéras V,Mignot L,Sastre-Garau X,Poupon MF,Pierga JY

更新日期：2008-01-01 00:00:00

abstract：:The complex process of tumor invasion requires the coordinated expression and activity of cell-substratum adhesive interactions and of cell-associated protease systems, which destroy the extracellular matrix (ECM), in order to enable the invading cells to simultaneously grip and destroy the anatomical barriers that co...

journal_title：Clinical & experimental metastasis

authors： Del Rosso M,Fibbi G,Pucci M,D'Alessio S,Del Rosso A,Magnelli L,Chiarugi V

更新日期：2002-01-01 00:00:00

abstract：:Metastatic spinal cord compression (MSCC) is a frequent phenomenon in advanced tumor diseases with often severe neurological impairments. Affected patients are often treated by decompressive laminectomy. To assess the impact of this procedure on Karnofsky Performance Index (KPI) and Frankel Grade (FG) at discharge, a ...

journal_title：Clinical & experimental metastasis

authors： Younsi A,Riemann L,Scherer M,Unterberg A,Zweckberger K

更新日期：2020-04-01 00:00:00

abstract：:The effects of gamma-irradiation on the properties of microvessel endothelial cells were studied in vitro. After incubating confluent endothelial cell monolayers in low serum-containing medium for 24 h, the monolayers were irradiated with 137Cs. Survival of rat lung microvessel endothelial (RLE) and mouse brain microv...

journal_title：Clinical & experimental metastasis

authors： Nicolson GL,Custead SE,Dulski KM,Milas L

更新日期：1991-09-01 00:00:00