Stereotactic radiation therapy in oligometastatic colorectal cancer: outcome of 102 patients and 150 lesions.

abstract：:Inflammatory breast cancer (IBC) is the most lethal form of locally advanced breast cancer known. IBC carries a guarded prognosis primarily due to rapid onset of disease, typically within six months, and the propensity of tumor emboli to invade the dermal lymphatics and spread systemically. Although the clinical manif...

journal_title：Clinical & experimental metastasis

authors： van Golen KL,Bao LW,Pan Q,Miller FR,Wu ZF,Merajver SD

更新日期：2002-01-01 00:00:00

abstract：:Metastasis is key to cancer mortality. Understanding its biology is vital for developing strategies to prevent and treat metastasis. Phenotypic assays to either study metastasis or evaluate anti-metastatic drugs are widely used in preclinical research. This technical note discusses the adherence of reporting essential...

journal_title：Clinical & experimental metastasis

authors： Boiy R,Steenbrugge J,Van Deun J,Hendrix A,Meyer E,De Wever O

更新日期：2018-12-01 00:00:00

abstract：:Electrochemotherapy (ECT) is a novel treatment for recurrent or in-transit unresectable melanoma metastases based on the administration of anti-neoplastic drugs followed by cancer cell electroporation. Whether ECT can also induce anti-tumour immunity is unclear. We addressed this issue investigating the presence of de...

journal_title：Clinical & experimental metastasis

authors： Gerlini G,Sestini S,Di Gennaro P,Urso C,Pimpinelli N,Borgognoni L

更新日期：2013-01-01 00:00:00

abstract：:This study compared phenotype and behaviour of seven head and neck squamous cell carcinoma (HNSCC) cell lines and normal epithelial cells. Indications were found that in HNSCC cells: 1) loss of the cell-cell adhesion molecule E-cadherin was correlated with loss of epithelioid cell morphology but not with loss of cell-...

journal_title：Clinical & experimental metastasis

authors： Tomson AM,Scholma J,Meijer B,Koning JG,de Jong KM,van der Werf M

更新日期：1996-11-01 00:00:00

abstract：:GPR56, a non-classical adhesion receptor, was previously reported to suppress tumor growth and metastasis in xenograft models using human melanoma cell lines. To understand whether GPR56 plays similar roles in the development of endogenous tumors, we analyzed cancer progression in Gpr56 (-/-) mice using a variety of t...

journal_title：Clinical & experimental metastasis

authors： Xu L,Begum S,Barry M,Crowley D,Yang L,Bronson RT,Hynes RO

更新日期：2010-04-01 00:00:00

abstract：:Literature data show that butyric acid derivatives bear a dose-dependent differentiative anti-proliferative activity on cancer cell lines and that apoptosis induction may play a major role. Although it was recently shown that solid lipid nanospheres (SLNs) are a suitable tool for several in vivo drug administration ro...

journal_title：Clinical & experimental metastasis

authors： Salomone B,Ponti R,Gasco MR,Ugazio E,Quaglino P,Osella-Abate S,Bernengo MG

更新日期：2000-01-01 00:00:00

abstract：:Solid tumors consist of genetically and phenotypically diverse subpopulations of cancer cells with unique capacities for growth, differentiation, and invasion. While the molecular and microenvironmental bases for heterogeneity are increasingly appreciated, the outcomes of such intratumor heterogeneity, particularly in...

journal_title：Clinical & experimental metastasis

authors： Carey SP,Starchenko A,McGregor AL,Reinhart-King CA

更新日期：2013-06-01 00:00:00

abstract：:Radiotherapy induces untargeted effects on normal tissues such as bone marrow. So alteration of microenvironment by ionizing irradiation is supposed to influence dynamic host-cancer ecosystem affecting cancer behavior including metastasis. Herein, the incidence of lung metastasis after high-dose irradiation has been i...

journal_title：Clinical & experimental metastasis

authors： Shin JW,Son JY,Raghavendran HR,Chung WK,Kim HG,Park HJ,Jang SS,Son CG

更新日期：2011-12-01 00:00:00

abstract：:Treating metastatic osteosarcoma (OS) remains a challenge in oncology. Current treatment strategies target the primary tumour rather than metastases and have a limited efficacy in the treatment of metastatic disease. Metastatic cells have specific features that render them less sensitive to therapy and targeting these...

journal_title：Clinical & experimental metastasis

authors： PosthumaDeBoer J,Witlox MA,Kaspers GJ,van Royen BJ

更新日期：2011-06-01 00:00:00

abstract：:Patients with small cell lung cancer (SCLC) are more likely to have synchronous brain metastasis (SBM) at the time of diagnosis than patients with any other extracranial primary malignancy. We sought to identify which factors predicted an increased risk of SBM in SCLC as well as which factors affected the prognosis of...

journal_title：Clinical & experimental metastasis

authors： Reddy SP,Dowell JE,Pan E

更新日期：2020-08-01 00:00:00

abstract：:Protein kinase C (PKC) has been shown to be a signal transducer during tumorigenesis, tumor cell invasion, and metastasis. Recent studies have reported that the PKC inhibitor, 7-hydroxystaurosporine, inhibits tumor cell invasion. However, the molecular mechanisms of this inhibition of invasion and metastasis are not w...

journal_title：Clinical & experimental metastasis

authors： Tsubaki M,Matsuoka H,Yamamoto C,Kato C,Ogaki M,Satou T,Itoh T,Kusunoki T,Tanimori Y,Nishida S

更新日期：2007-01-01 00:00:00

abstract：:Hypermethylation of the promoter region of tumor suppressor genes is associated with carcinogenesis in lung cancer (LC). Endobronchial ultrasound with needle aspiration (EBUS-NA) is a semi-invasive method for obtaining cell blocks from lymph nodes, which can be used for epigenetic analyses. To establish the relationsh...

journal_title：Clinical & experimental metastasis

authors： Millares L,Serra M,Andreo F,Sanz-Santos J,Montón C,Grimau C,Gallego M,Setó L,Combalia N,Llatjos M,Escoda R,Castellà E,Monsó E

更新日期：2015-10-01 00:00:00

abstract：:Tumor metastases are extremely rare in striated muscles. This is surprising given the fact that this tissue constitutes 60% of body weight. The present study focuses on small molecules produced and secreted by muscle cells which possess anti-cancer activity in vivo. Recently we have shown that a low molecular weight f...

journal_title：Clinical & experimental metastasis

authors： Bar-Yehuda S,Farbstein T,Barer F,Ohana G,Fishman P

更新日期：1999-01-01 00:00:00

abstract：:NIH3T3 cells transfected with an activated Ha-ras oncogene were treated with L-PHA, the leukoagglutinin from red kidney beans. Cell lines resistant to L-PHA-mediated cytotoxicity were isolated and found to contain reduced levels of L-PHA-binding oligosaccharides. The levels of N-acetylglucosaminyltransferase V, the en...

journal_title：Clinical & experimental metastasis

authors： Lu Y,Pelling JC,Chaney WG

更新日期：1994-01-01 00:00:00

abstract：:We have developed a novel hyperthermic treatment modality using magnetic materials for metastatic bone tumors. The purpose of this study is to show the results of novel hyperthermia for metastatic bone tumors. This novel hyperthermic treatment modality was used for 15 patients with 16 metastatic bone lesions. In seven...

journal_title：Clinical & experimental metastasis

authors： Matsumine A,Kusuzaki K,Matsubara T,Shintani K,Satonaka H,Wakabayashi T,Miyazaki S,Morita K,Takegami K,Uchida A

更新日期：2007-01-01 00:00:00

abstract：:Tumor specific quantitative RT-PCRs for two neuroblastoma specific molecular markers, tyrosine hydroxylase (TH) and GD2 synthase, were used to unequivocally demonstrate the neoplastic nature of the cells present in the cerebrospinal fluid of a neuroblastoma patient. After radical surgery of two separate tumoral lesion...

journal_title：Clinical & experimental metastasis

authors： Rosanda C,Gambini C,Carlini B,Conte M,De Bernardi B,Garaventa A,Corrias MV

更新日期：2006-01-01 00:00:00

abstract：:Human CD44 standard isoform (hCD44s) cDNA regulated by a high-expressing promoter was transfected into Balb/c 3T3 cells and the tumorigenic and metastatic capacities of the transfectants were investigated in nude mice at the subcutaneous site. One of three transfectants was tumorigenic. hCD44s expression was lost in t...

journal_title：Clinical & experimental metastasis

authors： Kogerman P,Sy MS,Culp LA

更新日期：1998-01-01 00:00:00

abstract：:Although the loss of sulfomucins was known as an indicator of carcinogenesis and malignant progression of colonic epithelia, it was not known whether the loss was directly related to the malignant behavior of colon carcinoma cells. We have studied the biological properties of LS174T human colon carcinoma cells before ...

journal_title：Clinical & experimental metastasis

authors： Tsuiji H,Nakatsugawa S,Ishigaki T,Irimura T

更新日期：1999-03-01 00:00:00

abstract：:Brain metastases are the most common intracranial tumors in adults, accounting for more than 50% of all such cases. The approach to and management of brain metastases have evolved significantly in recent years due to several reasons. These include advances in neurosurgical and radiotherapeutic techniques, improved sys...

journal_title：Clinical & experimental metastasis

authors： Thiagarajan A,Yamada Y

更新日期：2017-10-01 00:00:00

abstract：:It is recognised that stromal cells determine cancer progression. We have previously shown that active TGFbeta produced by rat colon carcinoma cells modulated NO production in rat endothelial cells. To elucidate the role of TGFbeta and NO in the mechanisms of interaction of colon carcinoma cells with stromal cells and...

journal_title：Clinical & experimental metastasis

authors： Lohm S,Peduto-Eberl L,Lagadec P,Renggli-Zulliger N,Dudler J,Jeannin JF,Juillerat-Jeanneret L

更新日期：2005-01-01 00:00:00

abstract：:Breast cancer (BC) is the most common cancer affecting women in the United States and metastatic breast cancer is the leading cause of death. The role estradiol plays in ER-positive BC is well-documented, but the way it contributes to ER-negative BC remains unclear. In the present study, we utilized an experimental mo...

journal_title：Clinical & experimental metastasis

authors： Yang X,Belosay A,Du M,Fan TM,Turner RT,Iwaniec UT,Helferich WG

更新日期：2013-08-01 00:00:00

abstract：:We investigated the role of signal transduction systems in the attachment of human uveal melanoma cells to matrix proteins. Ocular melanoma cells established from primary tumours attached rapidly to all substrates examined. Preferred substrates of attachment were collagens type I, III and IV and fibronectin rather tha...

journal_title：Clinical & experimental metastasis

authors： Mac Neil S,Wagner M,Rennie IG

更新日期：1994-11-01 00:00:00

abstract：:The chemokine CXCL12/SDF-1 and its receptors CXCR4 and CXCR7 play a major role in tumor invasion, proliferation and metastasis. Since both receptors are overexpressed on distinct tumor cells and on the tumor vasculature, we evaluated their potential as targets for detection of cancers by molecular imaging. We synthesi...

journal_title：Clinical & experimental metastasis

authors： Meincke M,Tiwari S,Hattermann K,Kalthoff H,Mentlein R

更新日期：2011-12-01 00:00:00

abstract：:Experimental hepatic metastasis of colorectal tumors is frequently studied by local intrahepatic tumor cell implantation. However, although a variety of factors of the implantation procedure may markedly influence tumor growth characteristics, standards are not defined yet. Herein, we studied the effect of different m...

journal_title：Clinical & experimental metastasis

authors： Kollmar O,Schilling MK,Menger MD

更新日期：2004-01-01 00:00:00

abstract：:Primary tumor growth and metastasis depend on angiogenesis, which is determined by the balance between proangiogenic and antiangiogenic molecules. Interferon (IFN)-alpha and -beta inhibit angiogenesis through downregulation of interleukin-8, matrix metalloproteinase-9, and basic fibroblast growth factor. To provide ev...

journal_title：Clinical & experimental metastasis

authors： McCarty MF,Bielenberg D,Donawho C,Bucana CD,Fidler IJ

更新日期：2002-01-01 00:00:00

abstract：:We have previously reported that induction of MMP-2 activation by Concanavalin A (ConA) in MDA-MB-231 human breast cancer cells involves both transcriptional and post-transcriptional mechanisms, and that the continuous presence of ConA is required for MMP-2 activation (Yu et al. Cancer Res, 55, 3272-7, 1995). In an ef...

journal_title：Clinical & experimental metastasis

authors： Yu M,Sato H,Seiki M,Spiegel S,Thompson EW

更新日期：1998-02-01 00:00:00

abstract：:MACC1 (metastasis associated in colon cancer 1) is a key driver that induces metastasis in colon cancer. However, the mechanisms by which MACC1 expression is transcriptionally regulated and the factors enriched at the MACC1 promoter remain largely unknown. The binding of proteins to specific DNA sites in the genome is...

journal_title：Clinical & experimental metastasis

authors： Huang Y,Xiang Y,Xie Z,Cai Y,Yang Q,Huang H,Chen Z,Xiao Z,He Q

更新日期：2020-08-01 00:00:00

abstract：:We studied the influence of 10 synthetic glycoamine analogs on colony formation in 0.3 and 0.9% agarose by metastatic human breast carcinoma (MDA-MB-435) and melanoma (TXM-13) cells. Nine synthetic analogs significantly inhibited the colony formation in 0.9% agarose of MDA-MB-435 human breast carcinoma cells; five com...

journal_title：Clinical & experimental metastasis

authors： Glinsky GV,Mossine VV,Price JE,Bielenberg D,Glinsky VV,Ananthaswamy HN,Feather MS

更新日期：1996-05-01 00:00:00

abstract：:The purpose of this study was to determine the subpopulation dynamics of human colon carcinoma (HCC) cells growing at orthotopic (cecum, liver) or ectopic (subcutis, kidney, spleen) sites in nude mice and to correlate any outgrowth of distinct clones with the differential expression of metastasis-related genes. Low me...

journal_title：Clinical & experimental metastasis

authors： Singh RK,Tsan R,Radinsky R

更新日期：1997-03-01 00:00:00

abstract：:Recent studies have indicated that KHT fibrosarcoma or B16 melanoma cell variants capable of forming experimental metastases in the lungs of mice after i.v. injection are created stochastically at high rates (approximately 10(-5)/cell/generation). Expression of this phenotype is unstable and hence expanding population...

journal_title：Clinical & experimental metastasis

authors： Young SD,Hill RP

更新日期：1986-07-01 00:00:00