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Molecular alterations as target for therapy in metastatic osteosarcoma: a review of literature.

Abstract：

:Treating metastatic osteosarcoma (OS) remains a challenge in oncology. Current treatment strategies target the primary tumour rather than metastases and have a limited efficacy in the treatment of metastatic disease. Metastatic cells have specific features that render them less sensitive to therapy and targeting these features might enhance the efficacy of current treatment. A detailed study of the biological characteristics and behaviour of metastatic OS cells may provide a rational basis for innovative treatment strategies. The aim of this review is to give an overview of the biological changes in metastatic OS cells and the preclinical and clinical efforts targeting the different steps in OS metastases and how these contribute to designing a metastasis directed treatment for OS.

journal_name

Clin Exp Metastasis

journal_title

Clinical & experimental metastasis

authors

PosthumaDeBoer J,Witlox MA,Kaspers GJ,van Royen BJ

doi

10.1007/s10585-011-9384-x

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

493-503

issue

5

eissn

0262-0898

issn

1573-7276

journal_volume

28

pub_type

杂志文章,评审

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