Gene transduction of NK4, HGF antagonist, inhibits in vitro invasion and in vivo growth of human pancreatic cancer.

abstract：:To evaluate the relationship between the c-kit proto-oncogene product and malignant transformation of human breast tissue, we examined the immunohistochemical expression of the c-kit proto-oncogene product in both malignant and non-malignant breast tissues. The immunohistochemical expression of the c-kit proto-oncogen...

journal_title：Clinical & experimental metastasis

authors： Ko CD,Kim JS,Ko BG,Son BH,Kang HJ,Yoon HS,Cho EY,Gong G,Ahn SH

更新日期：2003-01-01 00:00:00

abstract：:CD147 is expressed at low levels in normal tissues but frequently highly expressed in a wide range of tumor types such as lung, breast, and liver and therefore it is a potentially unique therapeutic target for these diverse tumor types. We previously generated a murine antibody HAb18 which suppresses matrix met al.lop...

journal_title：Clinical & experimental metastasis

authors： Wang Y,Yuan L,Yang XM,Wei D,Wang B,Sun XX,Feng F,Nan G,Wang Y,Chen ZN,Bian H

更新日期：2015-01-01 00:00:00

abstract：:NIH3T3 cells transfected with an activated Ha-ras oncogene were treated with L-PHA, the leukoagglutinin from red kidney beans. Cell lines resistant to L-PHA-mediated cytotoxicity were isolated and found to contain reduced levels of L-PHA-binding oligosaccharides. The levels of N-acetylglucosaminyltransferase V, the en...

journal_title：Clinical & experimental metastasis

authors： Lu Y,Pelling JC,Chaney WG

更新日期：1994-01-01 00:00:00

abstract：:Electrochemotherapy (ECT) is a novel treatment for recurrent or in-transit unresectable melanoma metastases based on the administration of anti-neoplastic drugs followed by cancer cell electroporation. Whether ECT can also induce anti-tumour immunity is unclear. We addressed this issue investigating the presence of de...

journal_title：Clinical & experimental metastasis

authors： Gerlini G,Sestini S,Di Gennaro P,Urso C,Pimpinelli N,Borgognoni L

更新日期：2013-01-01 00:00:00

abstract：:The effects of treatment of human lung carcinoma cell line A 549 with recombinant DNA-derived human leukocyte interferons A (rIFN-alpha A) or D (rIFN-alpha D), and human lymphoblastoid interferon (Wellferon) on in vitro cell invasion were investigated in a quantitative invasion assay using human amnion. The A 549 cell...

journal_title：Clinical & experimental metastasis

authors： Ravine TJ,Ledinko N

更新日期：1986-07-01 00:00:00

abstract：:Metastatic spinal cord compression (MSCC) is a frequent phenomenon in advanced tumor diseases with often severe neurological impairments. Affected patients are often treated by decompressive laminectomy. To assess the impact of this procedure on Karnofsky Performance Index (KPI) and Frankel Grade (FG) at discharge, a ...

journal_title：Clinical & experimental metastasis

authors： Younsi A,Riemann L,Scherer M,Unterberg A,Zweckberger K

更新日期：2020-04-01 00:00:00

abstract：:Spatial and temporal oxygen heterogeneity exists in most solid tumour microenvironments due to an inadequate vascular network supplying a dense population of tumour cells. An imbalance between oxygen supply and demand leads to hypoxia within a significant proportion of a tumour, which has been correlated to the likeli...

journal_title：Clinical & experimental metastasis

authors： Subarsky P,Hill RP

更新日期：2008-01-01 00:00:00

abstract：:We analysed population-based treatment and survival data of patients who presented with metastatic rectal cancer. All patients diagnosed with primary synchronous metastatic rectal cancer between 1992 and 2008 in the Eindhoven Cancer Registry area were included. Date of diagnosis was divided into three periods (1992-19...

journal_title：Clinical & experimental metastasis

authors： Lemmens VE,de Haan N,Rutten HJ,Martijn H,Loosveld OJ,Roumen RM,Creemers GJ

更新日期：2011-03-01 00:00:00

abstract：:Emerging data in myeloma and other cancers indicates that heparan sulfate proteoglycans promote tumor progression by enhancing their growth and metastasis. By acting as key regulators of cell signaling via their interactions with multiple growth and angiogenic factors, heparan sulfates mediate a shift in the microenvi...

journal_title：Clinical & experimental metastasis

authors： Sanderson RD,Yang Y

更新日期：2008-01-01 00:00:00

abstract：:Prostate cancer metastases form selectively in the bone marrow. Previously we demonstrated motility was important for the formation of primary prostatic epithelial cell colonies in bone marrow stroma (BMS) co-culture. In this study we looked at the influence of motility factors on the colony formation of epithelial ce...

journal_title：Clinical & experimental metastasis

authors： Lang SH,Clarke NW,George NJ,Testa NG

更新日期：1999-06-01 00:00:00

abstract：:Cancer cells with the surface marker profile CD44+/CD24- have previously been described to possess cancer stem cell-like properties. This manuscript evaluates those properties in ovarian cancer cell lines. The proportion of CD44+/CD24- cells corresponded to the clinical aggressiveness of each ovarian cancer cell line ...

journal_title：Clinical & experimental metastasis

authors： Meng E,Long B,Sullivan P,McClellan S,Finan MA,Reed E,Shevde L,Rocconi RP

更新日期：2012-12-01 00:00:00

abstract：:We have examined the role of platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) during the transendothelial migration of melanoma cells using a novel in vitro system. Comparable studies have suggested the involvement of PECAM-1 in leukocyte transendothelial migration. Such studies have been confirmed using i...

journal_title：Clinical & experimental metastasis

authors： Voura EB,Chen N,Siu CH

更新日期：2000-01-01 00:00:00

abstract：:The effect of thioglycollate-elicited macrophages (TG-M phi) on natural killer (NK)-cell activity and metastases formation in mice was investigated. Intravenously (i.v.) inoculated TG-M phi inhibited spleen NK activity of normal mice and abrogated polyinosinic: polycytidylic (poly I:C) induced augmentation of NK cell ...

journal_title：Clinical & experimental metastasis

authors： Gorelik E,Wiltrout RH,Brunda MJ,Bere WE,Herberman RB

更新日期：1985-04-01 00:00:00

abstract：:Despite an initial response to antihormonal therapies, the development of resistance will occur in a significant number of breast cancer patients. The mechanisms that underlie acquired resistance are not yet clear. Using a previously established in vitro cell model of tamoxifen resistance in MCF7 cells, shown to displ...

journal_title：Clinical & experimental metastasis

authors： Hiscox S,Morgan L,Barrow D,Dutkowskil C,Wakeling A,Nicholson RI

更新日期：2004-01-01 00:00:00

abstract：:In this study the relationship between brain structure and brain metastases (BM) occurrence was analyzed. A model for predicting the time of BM onset in patients with non-small cell lung cancer (NSCLC) was proposed. Twenty patients were used to develop the model, whereas the remaining 69 were used for independent vali...

journal_title：Clinical & experimental metastasis

authors： Yin G,Li C,Chen H,Luo Y,Orlandini LC,Wang P,Lang J

更新日期：2017-02-01 00:00:00

abstract：:This study compared phenotype and behaviour of seven head and neck squamous cell carcinoma (HNSCC) cell lines and normal epithelial cells. Indications were found that in HNSCC cells: 1) loss of the cell-cell adhesion molecule E-cadherin was correlated with loss of epithelioid cell morphology but not with loss of cell-...

journal_title：Clinical & experimental metastasis

authors： Tomson AM,Scholma J,Meijer B,Koning JG,de Jong KM,van der Werf M

更新日期：1996-11-01 00:00:00

abstract：:Within the cancer microenvironment, the growth and proliferation of cancer cells in the primary site as well as in the metastatic site represent a global biological phenomenon. To understand the growth, proliferation and progression of cancer either by local expansion and/or metastasis, it is important to understand t...

journal_title：Clinical & experimental metastasis

authors： Leong SP,Aktipis A,Maley C

更新日期：2018-08-01 00:00:00

abstract：:Metastatic castrate resistant prostate cancer (mCRPC) is responsible for the majority of prostate cancer deaths with the median survival after diagnosis being 2 years. The metastatic lesions often arise in the skeleton, and current treatment options are primarily palliative. Using guidelines set forth by the National ...

journal_title：Clinical & experimental metastasis

authors： Gallaher J,Cook LM,Gupta S,Araujo A,Dhillon J,Park JY,Scott JG,Pow-Sang J,Basanta D,Lynch CC

更新日期：2014-12-01 00:00:00

abstract：:Osteopontin (OPN) is a glycosylated, secreted phosphoprotein that functions both as a cell attachment and chemotactic factor. Elevated expression of OPN confers enhanced metastatic ability on transformed cells, suggesting that OPN may contribute to the malignant progression of tumors. Migration of mammary carcinoma ce...

journal_title：Clinical & experimental metastasis

authors： Khan SA,Cook AC,Kappil M,Günthert U,Chambers AF,Tuck AB,Denhardt DT

更新日期：2005-01-01 00:00:00

abstract：:The purpose of this study was to identify possible alterations in proto-oncogenes (c-fos, c-jun, c-erbB1, c-erbB2 and c-myc) at the protein level in primary lung carcinomas and simultaneous metastatic lymph nodes of 21 patients. The analysis showed that proteins of c-jun and c-myc were expressed in a significantly hig...

journal_title：Clinical & experimental metastasis

authors： Volm M,van Kaick G,Mattern J

更新日期：1994-07-01 00:00:00

abstract：:This short review offers an update on the first and second Multicenter Selective Lymphadenectomy Trials (MSLT-I and MSLT-II) for patients with melanoma, and briefly traces the development of intraoperative lymphatic mapping and sentinel node biopsy. ...

journal_title：Clinical & experimental metastasis

authors： Morton DL

更新日期：2012-10-01 00:00:00

abstract：:As a reliable model for osteosarcoma is lacking, three human cell lines (SaOS-2, U2OS and 143B) were evaluated in cell-based assays for proliferation, adhesion, migration, invasion, anchorage-independent growth, angiogenesis, mineralised nodule formation, plasmid transfection and oligonucleotide transfection. Tumor ta...

journal_title：Clinical & experimental metastasis

authors： Dass CR,Ek ET,Contreras KG,Choong PF

更新日期：2006-01-01 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is one of few cancers with rising incidence in North America. The prognosis of ccRCC is variable and difficult to predict. Stratification of patients according to disease aggressiveness can significantly improve patient management. We investigated the expression of the S100A11 p...

journal_title：Clinical & experimental metastasis

authors： Gabril M,Girgis H,Scorilas A,Rotondo F,Wala S,Bjarnason GA,Ding Q,Evans A,Tawedrous E,Pasic M,Finelli A,Al-Haddad S,Yousef GM

更新日期：2016-01-01 00:00:00

abstract：:Smad interacting protein 1 (SIP1) is an epithelial-mesenchymal transition (EMT)-inducible gene that plays a key role in tumor progression in various cancers. This study seeks to clarify the clinical and biological significance of SIP1 expression, especially in intestinal type gastric cancer. We analyzed the mRNA level...

journal_title：Clinical & experimental metastasis

authors： Okugawa Y,Inoue Y,Tanaka K,Kawamura M,Saigusa S,Toiyama Y,Ohi M,Uchida K,Mohri Y,Kusunoki M

更新日期：2013-04-01 00:00:00

abstract：:RANK ligand (RANKL), acting through its cognate receptor RANK, is a key factor for bone remodeling and metastasis by regulating the differentiation, survival and activation of osteoclasts. RANKL is also crucial for the development of mouse mammary glands during pregnancy and has been recently linked to the etiology of...

journal_title：Clinical & experimental metastasis

authors： Blake ML,Tometsko M,Miller R,Jones JC,Dougall WC

更新日期：2014-02-01 00:00:00

abstract：:About 30-40% of patients with renal cell carcinoma (RCC) will develop metastasis after curative nephrectomy. There is a strong need to identify the early metastasis with conventional and molecular risk factors. The present study aimed to test if analysis of the CA9 gene can provide useful information to predict early ...

journal_title：Clinical & experimental metastasis

authors： Li G,Feng G,Gentil-Perret A,Genin C,Tostain J

更新日期：2007-01-01 00:00:00

abstract：:We examined the in vivo anti-tumor activity of the benzoic acid derivative, TAC-101 (4-[3,5-bis(trimethylsilyl)benzamido] benzoic acid), for intrahepatic spread of JHH-7 human hepatocellular carcinoma (HCC) cells and its mechanism of action. Oral administration of TAC-101 markedly inhibited liver tumor of JHH-7 cells ...

journal_title：Clinical & experimental metastasis

authors： Murakami K,Matsuura T,Sano M,Hashimoto A,Yonekura K,Sakukawa R,Yamada Y,Saiki I

更新日期：1998-10-01 00:00:00

abstract：:Melanoma is an aggressive cutaneous malignancy with rapidly rising incidence. Diagnosis of controversial melanocytic lesions, correct prognostication of patients, selection of appropriate adjuvant and systemic therapies, and prediction of response to a given therapy remain very real challenges. Despite these challenge...

journal_title：Clinical & experimental metastasis

authors： Ankeny JS,Labadie B,Luke J,Hsueh E,Messina J,Zager JS

更新日期：2018-08-01 00:00:00

abstract：:Sentinel lymph node (SLN) mapping is common, however question remains as to what the ideal imaging agent is and how such an agent might provide reliable and stable localization of SLNs. (99m)Tc-labeled nanocolloid human serum albumin (Nanocoll) is the most commonly used radio-labeled colloid in Europe and remains the ...

journal_title：Clinical & experimental metastasis

authors： Tokin CA,Cope FO,Metz WL,Blue MS,Potter BM,Abbruzzese BC,Hartman RD,Joy MT,King DW,Christman LA,Vera DR,Wallace AM

更新日期：2012-10-01 00:00:00

abstract：:A new model for the study of spontaneous bone metastasis has been developed which allows for the quantification of metastatic tumor burden and cancer cell growth rate, and which describes the progressive changes in bone morphology. Walker 256 (W256) cells or vehicle were injected into the left upper thigh muscle of ma...

journal_title：Clinical & experimental metastasis

authors： Kostenuik PJ,Singh G,Suyama KL,Orr FW

更新日期：1992-11-01 00:00:00